{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:20:53Z","timestamp":1775092853808,"version":"3.50.1"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":79,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that leads to muscle weakness and paralysis. Fatigue is a disabling symptom, frequently reported in ALS, but remains under-investigated in this population. Thus, an accurate investigation of this symptom and possible associated factors in this clinical condition is needed to assist in the establishment of an adequate treatment approach.<\/jats:p><jats:p>\n          Objective\u2003To investigate the presence of fatigue in individuals with ALS and possible factors correlated with this symptom.<\/jats:p><jats:p>\n          Methods\u2003Sixty-five individuals with sporadic ALS participated in the present study. Demographic, clinical, and functional aspects were investigated. Evaluations involved the Fatigue Severity Scale (FSS), ALS Functional Scale (ALSRFS-R), and Quality of Life (QoL) questionnaire (ALSAQ-40). Descriptive and correlation analyses were performed with SPSS statistical program for Windows version 19.0 (IBM Corp., Armonk, NY, USA).<\/jats:p><jats:p>\n          Results\u2003Among the 65 individuals evaluated, 44.6% (n\u2009=\u200929) presented fatigue based on the FSS. The mean fatigue intensity was 5.4\u2009\u00b1\u20091.2 and only 10.4% used a specific medication for fatigue. Differences between the groups with and without fatigue were found regarding sex (p\u2009=\u20090.049), pain intensity (p\u2009=\u20090.026), functioning (p\u2009=\u20090.004), disease severity (p\u2009=\u20090.029), and QoL (p\u2009=\u20090.000). Fatigue was correlated with pain intensity (r\u2009=\u20090.425; p\u2009=\u20090.001), muscle strength (r\u2009=\u2009- 0.356; p\u2009=\u20090.004), functioning (r\u2009=\u2009- 0.363; p\u2009=\u20090.003), and QoL (r\u2009=\u20090.481; p\u2009=\u20090.000). No correlations were found with age, time since diagnosis, cramps, or other mobility parameters.<\/jats:p><jats:p>\n          Conclusions\u2003Fatigue is a common symptom among individuals with ALS and may be present in all stages of the disease. This symptom was correlated with worse functioning, poorer QoL, greater pain intensity, disease severity, muscle weakness, and the female sex in individuals with ALS.<\/jats:p>","DOI":"10.1055\/s-0042-1758563","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T23:47:56Z","timestamp":1671493676000},"page":"1045-1051","source":"Crossref","is-referenced-by-count":13,"title":["Fatigue in amyotrophic lateral sclerosis and correlated factors"],"prefix":"10.1055","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-5283","authenticated-orcid":false,"given":"Mariana Asmar","family":"Alencar","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Departamento de Fisioterapia, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7433-5522","authenticated-orcid":false,"given":"Bruna Laura","family":"Soares","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Departamento de Fisioterapia, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-2133","authenticated-orcid":false,"given":"Marcela Ferreira de Andrade","family":"Rangel","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Departamento de Fisioterapia, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5023-2294","authenticated-orcid":false,"given":"Juliana Silva","family":"Abdo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Departamento de Fisioterapia, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-0185","authenticated-orcid":false,"given":"Rayane Alves Pereira de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Departamento de Fisioterapia, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8866-0374","authenticated-orcid":false,"given":"Caroline Martins de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neuroci\u00eancia, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5027-9722","authenticated-orcid":false,"given":"Leonardo Cruz de","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neuroci\u00eancia, Belo Horizonte MG, Brazil."},{"name":"Universidade Federal de Minas Gerais, Departamento de Medicina Interna, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7829-9493","authenticated-orcid":false,"given":"Gisele de C\u00e1ssia","family":"Gomes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Departamento de Fisioterapia, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.mayocp.2018.04.007","article-title":"Amyotrophic Lateral Sclerosis: An Update for 2018","volume":"93","author":"B Oskarsson","year":"2018","journal-title":"Mayo Clin Proc"},{"issue":"11","key":"ref2","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrneurol.2011.153","article-title":"Clinical diagnosis and management of amyotrophic lateral sclerosis","volume":"7","author":"O 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