{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:53:33Z","timestamp":1740142413322,"version":"3.37.3"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"12","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003In the past twenty years, there has been an increasing interest among neuroscientists and physicians in mapping the cortical areas involved in the epileptogenic zone (EZ) through event-related potentials (ERPs) that enable the evaluation of the functional preservation of these areas. The present review is an update on publications on this topic.<\/jats:p><jats:p>\n          Objective\u2003To investigate the accuracy of the cognitive evoked of the medial temporal lobe P300 (MTL-P300) potential in detecting the EZ in temporal lobe epilepsy (TLE).<\/jats:p><jats:p>\n          Methods\u2003The systematic review of articles on the PubMed, Embase and Lilacs databases was conducted between February and December 2020. Articles published in English from 1985 to December 2020 were included. Additional studies were identified by searching the references of the selected studies and review articles. The studies were included for the following reasons: in-depth intracranial electroencephalography (iEEG) analysis of hippocampal activity; investigations of patients with TLE; and correlations between regarding the ERP results obtained in the temporal regions (MTL-P300) and the EZ.<\/jats:p><jats:p>\n          Results\u2003In the three studies analyzed, the authors were able to define the laterality of the EZ during the preoperative investigation through the MTL-P300 results. The sensitivity of this method was of \u223c 70% to 80%, and the specificity between 70% and 94.7%. One of the limitations of the present review was the low number of studies.<\/jats:p><jats:p>\n          Conclusion\u2003There is evidence that the reduced amplitude of the MTL-P300 has high specificity in identifying the EZ, and this is a good marker for diagnosis in unilateral TLE. The low sensitivity and negative likelihood ratios negative that a normal MTL-P300 response does not exclude the epileptogenicity of the hippocampus.<\/jats:p>","DOI":"10.1055\/s-0042-1758643","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T23:50:12Z","timestamp":1672357812000},"page":"1274-1281","source":"Crossref","is-referenced-by-count":0,"title":["MTL-P300 as a marker of the epileptogenic zone and hippocampal functionality in the presurgical evaluation of temporal lobe epilepsy: a systematic review"],"prefix":"10.1055","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2135-3169","authenticated-orcid":false,"given":"Daniela de Andrade","family":"Morange","sequence":"additional","affiliation":[{"name":"Universit\u00e9 d'Aix-Marseille, Institut de Neurosciences des Syst\u00e8mes, Marseille, France."},{"name":"Hospital Universit\u00e1rio Prof. Edgard Santos, Servi\u00e7o de Neurofisiologia Cl\u00ednica, Salvador BA, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1004-1784","authenticated-orcid":false,"given":"Martha Silvia","family":"Martinez-Silveira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Instituto Gon\u00e7alo Muniz, Salvador BA, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1474-9154","authenticated-orcid":false,"given":"Magali Teres\u00f3polis Reis","family":"Amaral","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Feira de Santana, Salvador BA, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8632-3454","authenticated-orcid":false,"given":"Agn\u00e8s","family":"Trebuchon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 d'Aix-Marseille, Institut de Neurosciences des Syst\u00e8mes, Marseille, France."},{"name":"Assistance Publique - 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