{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:08:48Z","timestamp":1790086128552,"version":"4.0.1"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"12","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Botulism is a rare and potentially fatal neuroparalytic syndrome caused by the gram-positive anaerobe spore-forming bacterium Clostridium botulinum. The microorganism produces a neurotoxin that inhibits the presynaptic release of acetylcholine at the neuromuscular junction, clinically leading to a myasthenic syndrome.<\/jats:p><jats:p>\n          Objective\u2003To describe the recent outbreak of botulism cases and its demographic, clinical, and laboratory characteristics.<\/jats:p><jats:p>\n          Methods\u2003We report 4 patients with botulism in the recent outbreak occurred between 2017 and 2019 in the state of Amazon.<\/jats:p><jats:p>\n          Results\u2003Out of four patients with botulism, three contracted it from eating contaminated food and one had wound botulism. We emphasize the excellent clinical outcome of the different disease presentations in our case series.<\/jats:p><jats:p>\n          Conclusion\u2003The temporal proximity of these reports may suggest a new rise in the number of cases in the upcoming years. A possible hypothesis is that the rarity of the disease decreased the awareness regarding the primary prevention or even a diagnosis by an untrained physician.<\/jats:p>","DOI":"10.1055\/s-0042-1758651","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T23:50:12Z","timestamp":1672357812000},"page":"1227-1232","source":"Crossref","is-referenced-by-count":5,"title":["Botulism in the Brazilian Amazon: a life-threatening disease in a neglected population"],"prefix":"10.1055","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1057-1101","authenticated-orcid":false,"given":"Louise Makarem","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amazonas, Faculdade de Medicina, Manaus AM, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3243-970X","authenticated-orcid":false,"given":"Daniel Buzaglo","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amazonas, Faculdade de Medicina, Manaus AM, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2943-6137","authenticated-orcid":false,"given":"Lucas de Cristo Rojas","family":"Cabral","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amazonas, Faculdade de Medicina, Manaus AM, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4093-226X","authenticated-orcid":false,"given":"Mar\u00edlia Rosa Abtibol","family":"Bernardino","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amazonas, Faculdade de Medicina, Manaus AM, Brazil."},{"name":"Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus AM, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2840-451X","authenticated-orcid":false,"given":"Pablo Vin\u00edcius Silveira","family":"Feitoza","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amazonas, Faculdade de Medicina, Manaus AM, Brazil."},{"name":"Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus AM, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1345\/aph.1R646","article-title":"Foodborne botulism treated with heptavalent botulism antitoxin","volume":"47","author":"S E Hill","year":"2013","journal-title":"Ann Pharmacother"},{"issue":"S 01","key":"ref2","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1046\/j.1526-4610.43.7s.4.x","article-title":"Synaptic transmission: inhibition of neurotransmitter release by botulinum toxins","volume":"43","author":"O Dolly","year":"2003","journal-title":"Headache"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"e01469","DOI":"10.1128\/mBio.01469-18","article-title":"Botulinum neurotoxin-producing bacteria. Isn't it time that we called a species a species?","volume":"9","author":"T Smith","year":"2018","journal-title":"MBio"},{"issue":"01","key":"ref4","first-page":"1","article-title":"Why Are Botulinum Neurotoxin-Producing Bacteria So Diverse and Botulinum Neurotoxins So Toxic?","volume":"11","author":"B Poulain","journal-title":"Toxins (Basel)"},{"issue":"03","key":"ref5","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/cid\/cis901","article-title":"National outbreak of type a foodborne botulism associated with a widely distributed commercially canned hot dog chili sauce","volume":"56","author":"P C Juliao","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.4315\/0362-028X.JFP-11-128","article-title":"Three outbreaks of foodborne botulism caused by unsafe home canning of vegetables\u2013Ohio and Washington, 2008 and 2009","volume":"74","author":"K Date","year":"2011","journal-title":"J Food Prot"},{"issue":"09","key":"ref7","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.3201\/eid1009.030745","article-title":"Foodborne botulism in the United States, 1990-2000","volume":"10","author":"J Sobel","year":"2004","journal-title":"Emerg Infect Dis"},{"issue":"03","key":"ref8","first-page":"400","article-title":"Familiar outbreak of botulism at Cear\u00e1 state, Brazil: case report","volume":"44","author":"M M Barboza","journal-title":"Rev Soc Bras Med Trop"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7002a1","article-title":"Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021","volume":"70","author":"A K Rao","year":"2021","journal-title":"MMWR Recomm Rep"},{"issue":"05","key":"ref11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1542\/pir.2015-0018","article-title":"Botulism","volume":"37","author":"M A Carrillo-Marquez","year":"2016","journal-title":"Pediatr Rev"},{"issue":"08","key":"ref12","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1086\/444507","volume":"41","author":"J. Botulism Sobel","journal-title":"Clin Infect Dis"},{"issue":"07","key":"ref13","first-page":"300","article-title":"Atypical botulism sparing palsy of extraocular muscles","volume":"12","author":"H J Gdynia","year":"2007","journal-title":"Eur J Med Res"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12893-017-0300-4","article-title":"Effective and rapid treatment of wound botulism, a case report","volume":"17","author":"M Schulte","year":"2017","journal-title":"BMC Surg"},{"issue":"25","key":"ref15","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1056\/NEJMicm1003352","article-title":"Images in clinical medicine: Wound botulism","volume":"363","author":"A H Sam","year":"2010","journal-title":"N Engl J Med"},{"issue":"04","key":"ref16","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/mus.27370","article-title":"Neurophysiological patterns of acute and post-acute foodborne botulism","volume":"64","author":"C Boccagni","year":"2021","journal-title":"Muscle Nerve"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1177\/0883073807308707","article-title":"Infant botulism: 20 years' experience at a single institution","volume":"22","author":"L Tseng-Ong","year":"2007","journal-title":"J Child Neurol"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.pediatrneurol.2015.01.006","article-title":"Infant botulism: review and clinical update","volume":"52","author":"L K Rosow","year":"2015","journal-title":"Pediatr Neurol"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1758651.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:29:46Z","timestamp":1683246586000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1758651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":17,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,29]]},"published-print":{"date-parts":[[2022,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1758651","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0004-282X","1678-4227"],"issn-type":[{"value":"0004-282X","type":"print"},{"value":"1678-4227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}