{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T07:28:09Z","timestamp":1745220489720,"version":"3.37.3"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg J (N Y)"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Phyllodes is a rare tumor found exclusively in females. It can be classified into benign, intermediate, or malignant variety based on the aggressive nature of the disease. With adequate preoperative clinical assessment combined with histopathology and radiological investigations the adequate treatment strategy can be formulated to avoid future recurrences. Complete androgen insensitivity syndrome (CAIS) is associated with a genotypic male, which can be confirmed by karyotyping, with phenotypic female characteristics. The present case is the first case of bilateral breast phyllodes tumor in a patient with CAIS. Preoperative assessment was suggestive of bilateral phyllodes tumor with bilateral gonads in the inguinal region which was confirmed to be testis postoperatively on histopathological analysis. A brief case report with review of literature is presented.<\/jats:p>","DOI":"10.1055\/s-0042-1758668","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T23:28:43Z","timestamp":1675466923000},"page":"e23-e27","source":"Crossref","is-referenced-by-count":3,"title":["Bilateral Breast Phyllodes Tumor in Androgen Insensitivity Syndrome"],"prefix":"10.1055","volume":"09","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2794-2455","authenticated-orcid":false,"given":"Aishwarya Sunil","family":"Dutt","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-4428","authenticated-orcid":false,"given":"Girish","family":"Bakhshi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-2584","authenticated-orcid":false,"given":"Chandrakant","family":"Sabale","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Landge","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0685-4854","authenticated-orcid":false,"given":"Sushrut","family":"Baligar","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajalakshmi","family":"V.","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhu","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sampada","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chettubattina Ravi","family":"Teja","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0140-6736(12)60071-3","article-title":"Androgen insensitivity syndrome","volume":"380","author":"I A Hughes","year":"2012","journal-title":"Lancet"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1016\/j.jpag.2014.08.005","article-title":"Invasive ductal carcinoma in a 46,XY partial androgen insensitivity syndrome patient on hormone therapy","volume":"28","author":"H R Hoefgen","year":"2015","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"09","key":"ref3","first-page":"e10288","article-title":"Phyllodes tumors of the breast: a literature review","volume":"12","author":"M Rayzah","year":"2020","journal-title":"Cureus"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"e488","DOI":"10.1542\/peds.2006-0738","article-title":"Consensus statement on management of intersex disorders","volume":"118","author":"P A Lee","year":"2006","journal-title":"Pediatrics"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jpag.2007.09.006","article-title":"Complete androgen insensitivity syndrome\u2013a review","volume":"21","author":"M B Oakes","year":"2008","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/LGT.0b013e3182702796","article-title":"Androgen insensitivity syndrome with gynandroblastoma and vulvar leiomyoma: case report and literature review","volume":"17","author":"W Tian","year":"2013","journal-title":"J Low Genit Tract Dis"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00004347-199104000-00002","article-title":"The androgen insensitivity syndrome, a clinicopathologic study of 43 cases","volume":"l0","author":"J L Rutgers","year":"1991","journal-title":"Int J Gynecol Pathol"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/path.1890","article-title":"Testicular development in the complete androgen insensitivity syndrome","volume":"208","author":"S E Hannema","year":"2006","journal-title":"J Pathol"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/1097-0142(195111)4:6<1286::AID-CNCR2820040614>3.0.CO;2-T","article-title":"Cystosarcoma phyllodes of the breast: a malignant and a benign tumor; a clinicopathological study of seventy-seven cases","volume":"4","author":"N Treves","year":"1951","journal-title":"Cancer"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1245\/s10434-014-3909-x","article-title":"Surgical treatment of borderline and malignant phyllodes tumors: the effect of the extent of resection and tumor characteristics on patient outcome","volume":"21","author":"E O Onkendi","year":"2014","journal-title":"Ann Surg Oncol"},{"issue":"08","key":"ref11","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1245\/s10434-012-2307-5","article-title":"Clinicopathologic risk factors for the local recurrence of phyllodes tumors of the breast","volume":"19","author":"J H Jang","year":"2012","journal-title":"Ann Surg Oncol"}],"container-title":["The Surgery Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1758668.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T23:29:06Z","timestamp":1675466946000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1758668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":11,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,2,3]]},"published-print":{"date-parts":[[2023,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1758668","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2378-5128","2378-5136"],"issn-type":[{"type":"print","value":"2378-5128"},{"type":"electronic","value":"2378-5136"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}