{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T09:04:15Z","timestamp":1751015055634,"version":"3.37.3"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"12","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background\u2003Gelastic seizures are extremely rare, short-lasting, unprovoked, and uncontrollable laughing attacks. We conducted this retrospective evaluation to determine whether these symptoms, manifesting in different forms, such as cheerful laughter, laughing, smiling, and sobbing had any value in terms of etiology or localization.<\/jats:p><jats:p>Methods\u2003A total of 31 patients who exhibited bouts of laughing or crying and who were under follow-up between 2000 and 2019 at tertiary epilepsy centers were included in the study. Laughing seizures were divided into three groups in terms of semiology (i.e., laughter with mirth, laughter without mirth, and smile). Dacrystic seizures were accompanied by some gelastic seizures and were divided into two groups in terms of semiology (i.e., weeping loudly [motor and voice-sobbing] and crying).<\/jats:p><jats:p>Results\u2003Of the 27 patients with laughing seizures, 12 had seizures that manifested with smiling, 7 had seizures that manifested with laughing and mirth, and 8 had seizures that manifested with laughter without mirth. Dacrystic-gelastic seizures were observed in four patients, among whom 2 patients had crying and laughter without mirth and 2 patients had weeping loudly and laughter without mirth episodes.<\/jats:p><jats:p>Conclusion\u2003Gelastic and dacrystic seizures often suggest hypothalamic hamartomas, in the literature. This rare ictal behavior can originate from different cortical locations and lesions of a different nature. However, we found that gelastic seizures with smiling were a more homogenous group with regard to location in the temporal lobe, which we aimed to show by evaluating the patients included in this study.<\/jats:p>","DOI":"10.1055\/s-0042-1758755","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T23:50:12Z","timestamp":1672357812000},"page":"1204-1212","source":"Crossref","is-referenced-by-count":1,"title":["A clinical evaluation of gelastic and dacrystic seizures: a multicenter study"],"prefix":"10.1055","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-8605","authenticated-orcid":false,"given":"Aylin Bican","family":"Demir","sequence":"additional","affiliation":[{"name":"Bursa Uludag University, Faculty of Medicine, Epilepsy Center, Department of Neurology, Bursa, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0955-702X","authenticated-orcid":false,"given":"Ba\u015fak Y\u0131lmaz","family":"\u00d6z","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Epilepsy Center, Department of Neurology, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3502-4785","authenticated-orcid":false,"given":"Mustafa Onur","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Epilepsy Center, Department of Neurology, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-5971","authenticated-orcid":false,"given":"Bengi G\u00fcl","family":"T\u00fcrk","sequence":"additional","affiliation":[{"name":"Dr Selahattin Cizrelioglu Cizre State Hospital, Department of Neurology, Hakkari, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1878-0696","authenticated-orcid":false,"given":"Taner","family":"Tanr\u0131verdi","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Epilepsy Center, Department of Neurosurgery, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2716-1985","authenticated-orcid":false,"given":"Ahmet","family":"Bekar","sequence":"additional","affiliation":[{"name":"Bursa Uludag University, Faculty of Medicine, Epilepsy Center, Department of Neurosurgery, Bursa, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-5430","authenticated-orcid":false,"given":"Naz","family":"Yeni","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Epilepsy Center, Department of Neurology, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9435-6037","authenticated-orcid":false,"given":"\u0130brahim","family":"Bora","sequence":"additional","affiliation":[{"name":"Bursa Uludag University, Faculty of Medicine, Epilepsy Center, Department of Neurology, Bursa, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.2147\/ndt.s2173","article-title":"Gelastic seizures associated with hypothalamic hamartomas. An update in the clinical presentation, diagnosis and treatment","volume":"4","author":"J F T\u00e9llez-Zenteno","year":"2008","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"04","key":"ref2","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"I E Scheffer","year":"2017","journal-title":"Epilepsia"},{"issue":"01","key":"ref3","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/epi.12868","article-title":"Gelastic seizures: incidence, clinical and EEG features in adult patients undergoing video-EEG telemetry","volume":"56","author":"S Kovac","year":"2015","journal-title":"Epilepsia"},{"issue":"06","key":"ref5","doi-asserted-by":"publisher","first-page":"1069-77","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies","volume":"51","author":"P Kwan","year":"2010"},{"key":"ref6","first-page":"609","volume-title":"Outcome with respect to epileptic seizures. In Engel J Jr, ed. Surgical treatment of the epilepsies","author":"J Engel Jr","year":"1993"},{"issue":"01","key":"ref7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/ane.12209","article-title":"Classification of hypothalamic hamartoma and prognostic factors for surgical outcome","volume":"130","author":"C D Li","year":"2014","journal-title":"Acta Neurol Scand"},{"issue":"01","key":"ref8","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1528-1157.1971.tb03916.x","article-title":"Epileptic (gelastic) laughter","volume":"12","author":"G G Gascon","year":"1971","journal-title":"Epilepsia"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1093\/brain\/awg226","article-title":"Neural correlates of laughter and humour","volume":"126","author":"B Wild","year":"2003","journal-title":"Brain"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.yebeh.2014.03.024","article-title":"Different localizations underlying cortical gelastic epilepsy: case series and review of literature","volume":"35","author":"T P Tran","year":"2014","journal-title":"Epilepsy Behav"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1684\/j.1950-6945.2006.tb00188.x","article-title":"Gelastic seizures involving the right parietal lobe","volume":"8","author":"H Y Shin","year":"2006","journal-title":"Epileptic Disord"},{"issue":"05","key":"ref12","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1002\/acn3.51033","article-title":"Electrophysiological properties and seizure networks in hypothalamic hamartoma","volume":"7","author":"D Wang","year":"2020","journal-title":"Ann Clin Transl Neurol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1093\/brain\/116.4.757","article-title":"Mirth, laughter and gelastic seizures","volume":"116","author":"S Arroyo","year":"1993","journal-title":"Brain"},{"issue":"02","key":"ref14","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1111\/j.1528-1167.2006.00442.x","article-title":"Contralateral smile and laughter, but no mirth, induced by electrical stimulation of the cingulate cortex","volume":"47","author":"F Sperli","year":"2006","journal-title":"Epilepsia"},{"issue":"01","key":"ref15","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.yebeh.2012.02.013","article-title":"The gelastic seizures-hypothalamic hamartoma syndrome: facts, hypotheses, and perspectives","volume":"24","author":"S Striano","year":"2012","journal-title":"Epilepsy Behav"},{"issue":"03","key":"ref16","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1159\/000081858","article-title":"A note on gelastic epilepsy","volume":"52","author":"J M Pearce","year":"2004","journal-title":"Eur Neurol"},{"issue":"02","key":"ref17","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1159\/000273080","article-title":"Cryptogenic gelastic epilepsy originating from the right temporal lobe","volume":"19","author":"Y Chai","year":"2010","journal-title":"Med Princ Pract"},{"issue":"01","key":"ref18","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0168-0102(02)00012-3","article-title":"Different patterns of dipole source localization in gelastic seizure with or without a sense of mirth","volume":"43","author":"H Iwasa","year":"2002","journal-title":"Neurosci Res"},{"issue":"12","key":"ref19","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1111\/j.1528-1157.1998.tb01337.x","article-title":"Ictal smile","volume":"39","author":"J L Molinuevo","year":"1998","journal-title":"Epilepsia"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yebeh.2016.03.012","article-title":"Ictal crying","volume":"59","author":"A A Asadi-Pooya","year":"2016","journal-title":"Epilepsy Behav"},{"issue":"10","key":"ref21","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1212\/wnl.43.10.2113","article-title":"Crying seizures","volume":"43","author":"D Luciano","year":"1993","journal-title":"Neurology"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1758755.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T05:53:09Z","timestamp":1728625989000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1758755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":20,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,29]]},"published-print":{"date-parts":[[2022,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1758755","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0004-282X","1678-4227"],"issn-type":[{"type":"print","value":"0004-282X"},{"type":"electronic","value":"1678-4227"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}