{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:12:33Z","timestamp":1773976353153,"version":"3.50.1"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Knee Surg"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Total knee arthroplasty (TKA) is the sole disease-modifying intervention for end-stage osteoarthritis. However, the temporal trends and stratification of age and patient demographics of pain and function levels at which surgeons perform TKA have not been characterized. The present investigation aimed to analyze the temporal trends of preoperative pain and functional patient-reported outcomes measures (PROMs) over the past 5 years when stratifying patient demographics. A prospective cohort of all patients who underwent primary elective TKA between January 2016 and December 2020 at a North American integrated tertiary health care system was retrospectively reviewed. The primary outcome was quarterly baseline (preoperative) pain and function PROM values before primary elective TKA. Evaluated PROMs included Knee Osteoarthritis Outcome Score (KOOS)-pain and KOOS-physical function shortform (PS) for the 5-year study period and were stratified by patient demographics (age, sex, race, and body mass index [BMI]). A total of 10,327 patients were analyzed. Preoperative pain levels remained unchanged over the study period for patients in the 45- to 64-year category (P-trend\u2009=\u20090.922). Conversely, there was a significant improvement in preoperative pain levels in the 65+ years group. Sex-stratified trends between males and females did not demonstrate a significant change in pre-TKA baseline pain over the study period (P-trend\u2009=\u20090.347 and P-trend\u2009=\u20090.0744). Both white and black patients demonstrated consistent KOOS-pain levels throughout the study period (P-trend\u2009=\u20090.0855 and P-trend\u2009=\u20090.626). Only white patients demonstrated improving preoperative KOOS-PS (P-trend\u2009=\u20090.0001), while black and \u201cother\u201d patients demonstrated consistent lower preoperative functional levels throughout the study period (P-trend\u2009=\u20090.456 and P-trend\u2009=\u20090.871). All BMI categories demonstrated relatively consistent preoperative KOOS-pain and KOOS-PS except for overweight and obese patients who demonstrated progressive improvement in preoperative KOOS-PS over the study period. Patients and surgeons are electing to perform primary TKA at higher levels of preoperative function. Stratification by race showed black patients did not experience a similar trend of improving function and exhibited a consistently lower functional level versus white patients. This disparity is likely to be multifactorial but may indicate underlying barriers to TKA access.<\/jats:p>","DOI":"10.1055\/s-0042-1758774","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:43:10Z","timestamp":1671842590000},"page":"1454-1461","source":"Crossref","is-referenced-by-count":13,"title":["When Do We Perform Elective Total Knee Arthroplasty? General and Demographic-Specific Trends of Preoperative Pain and Function among 10,327 Patients"],"prefix":"10.1055","volume":"36","author":[{"given":"Rui W.","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed K.","family":"Emara","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Orr","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison K.","family":"Klika","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro J.","family":"Rull\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Pumo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor E.","family":"Krebs","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Molloy","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-7538","authenticated-orcid":false,"given":"Nicolas S.","family":"Piuzzi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"e0007","DOI":"10.2106\/JBJS.OA.18.00007","article-title":"Quality-adjusted life years after hip and knee arthroplasty: health-related quality of life after 12,782 joint replacements","volume":"3","author":"J F Konopka","year":"2018","journal-title":"JBJS Open Access"},{"issue":"17","key":"ref2","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1505467","article-title":"A randomized, controlled trial of total knee replacement","volume":"373","author":"S T Skou","year":"2015","journal-title":"N Engl J Med"},{"key":"ref3","first-page":"454873","article-title":"Current surgical treatment of knee 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