{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:11:36Z","timestamp":1777464696079,"version":"3.51.4"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003As survival rates of infants born with esophageal atresia (EA) have improved considerably, research interests are shifting from viability to morbidity and longer-term outcomes. This review aims to identify all parameters studied in recent EA research and determine variability in their reporting, utilization, and definition.<\/jats:p><jats:p>\n          Materials and Methods\u2003Following PRISMA guidelines, we performed a systematic review of literature regarding the main EA care process, published between 2015 and 2021, combining the search term \u201cesophageal atresia\u201d with \u201cmorbidity,\u201d \u201cmortality,\u201d \u201csurvival,\u201d \u201coutcome,\u201d or \u201ccomplication.\u201d Described outcomes were extracted from included publications, along with study and baseline characteristics.<\/jats:p><jats:p>\n          Results\u2003From 209 publications that met the inclusion criteria, 731 studied parameters were extracted and categorized into patient characteristics (n\u2009=\u2009128), treatment and care process characteristics (n\u2009=\u2009338), and outcomes (n\u2009=\u2009265). Ninety-two of these were reported in more than 5% of included publications. Most frequently reported characteristics were sex (85%), EA type (74%), and repair type (60%). Most frequently reported outcomes were anastomotic stricture (72%), anastomotic leakage (68%), and mortality (66%).<\/jats:p><jats:p>\n          Conclusion\u2003This study demonstrates considerable heterogeneity of studied parameters in EA research, emphasizing the need for standardized reporting to compare results of EA research. Additionally, the identified items may help develop an informed, evidence-based consensus on outcome measurement in esophageal atresia research and standardized data collection in registries or clinical audits, thereby enabling benchmarking and comparing care between centers, regions, and countries.<\/jats:p>","DOI":"10.1055\/s-0042-1758828","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:06:40Z","timestamp":1676592400000},"page":"129-137","source":"Crossref","is-referenced-by-count":12,"title":["Variability in the Reporting of Baseline Characteristics, Treatment, and Outcomes in Esophageal Atresia Publications: A Systematic Review"],"prefix":"10.1055","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4474-2930","authenticated-orcid":false,"given":"Nadine","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Intensive Care Unit, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands"},{"name":"Dutch Institute for Clinical Auditing, European Pediatric Surgical Audit, Leiden, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Brendel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hannover Medical School, Hannover, Niedersachsen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-9204","authenticated-orcid":false,"given":"Simon","family":"Eaton","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Intensive Care Unit, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands"},{"name":"Developmental Biology and Cancer Research and Teaching Programme, UCL Great Ormond Street Institute of Child Health, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel","family":"Hall","sequence":"additional","affiliation":[{"name":"University Surgery Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Thursfield","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest L.W.","family":"van Heurn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Emma's Children's Hospital, Amsterdam UMC, Amsterdam, the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benno","family":"Ure","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Hannover Medical School, Hannover, Niedersachsen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Wijnen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Intensive Care Unit, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/bdra.23067","article-title":"Prevalence of esophageal atresia among 18 international birth defects surveillance programs","volume":"94","author":"N Nassar","year":"2012","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/bdr2.1891","article-title":"Survival of infants born with esophageal atresia among 24 international birth defects surveillance programs","volume":"113","author":"J C Bell","year":"2021","journal-title":"Birth Defects Res"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1055\/s-0038-1668150","article-title":"State of play: eight decades of surgery for esophageal atresia","volume":"29","author":"J Zimmer","year":"2019","journal-title":"Eur J Pediatr Surg"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1055\/s-0039-1693116","article-title":"ERNICA consensus conference on the management of patients with esophageal atresia and tracheoesophageal fistula: diagnostics, preoperative, operative, and postoperative management","volume":"30","author":"C Dingemann","year":"2020","journal-title":"Eur J Pediatr Surg"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/MPG.0000000000001401","article-title":"ESPGHAN-NASPGHAN guidelines for the evaluation and treatment of gastrointestinal and nutritional complications in children with esophageal atresia-tracheoesophageal fistula","volume":"63","author":"U Krishnan","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1055\/s-0040-1702223","article-title":"Publication trends and global collaborations on esophageal atresia research: a bibliometric study","volume":"31","author":"X Feng","year":"2021","journal-title":"Eur J Pediatr Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"n160","DOI":"10.1136\/bmj.n160","article-title":"PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews","volume":"372","author":"M J Page","year":"2021","journal-title":"BMJ"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1055\/s-0038-1672144","article-title":"Generic health-related quality of life after repair of esophageal atresia and its determinants within a German-Swedish cohort","volume":"29","author":"S Flieder","year":"2019","journal-title":"Eur J Pediatr Surg"},{"issue":"05","key":"ref11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s12098-015-1930-0","article-title":"Long-term prognosis of patients with esophageal atresia and\/or tracheoesophageal fistula","volume":"83","author":"U Bakal","year":"2016","journal-title":"Indian J Pediatr"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jpedsurg.2020.07.014","article-title":"Quality of life after esophageal replacement in children","volume":"56","author":"G Gallo","year":"2021","journal-title":"J Pediatr Surg"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jpedsurg.2019.08.012","article-title":"Outcomes in adulthood of gastric transposition for complex and long gap esophageal atresia","volume":"55","author":"E Hannon","year":"2020","journal-title":"J Pediatr Surg"},{"issue":"07","key":"ref14","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.jpedsurg.2020.10.029","article-title":"Traumatic stress, mental health, and quality of life in adolescents with esophageal atresia","volume":"57","author":"A Mikkelsen","year":"2022","journal-title":"J Pediatr Surg"},{"issue":"07","key":"ref15","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1007\/s00595-016-1462-x","article-title":"Long-term morbidity in adolescents and young adults with surgically treated esophageal atresia","volume":"47","author":"H Okuyama","year":"2017","journal-title":"Surg Today"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cgh.2017.11.008","article-title":"High prevalence of Barrett's esophagus and esophageal squamous cell carcinoma after repair of esophageal atresia","volume":"16","author":"F WT Vergouwe","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1055\/s-0038-1676825","article-title":"Developmental status of children operated for esophageal atresia with or without tracheoesophageal fistula along with maternal stress, their quality of life, and coping abilities at AIIMS, New Delhi","volume":"29","author":"V Kumari","year":"2019","journal-title":"Eur J Pediatr Surg"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1055\/s-0041-1731391","article-title":"Long-term outcomes and health-related quality of life in a Swiss patient group with esophageal atresia","volume":"32","author":"A di Natale","year":"2022","journal-title":"Eur J Pediatr Surg"},{"issue":"07","key":"ref19","first-page":"587","article-title":"Patient-reported outcome measures and clinical outcomes in children with foregut anomalies","volume":"8","author":"I I Sreeram","year":"2021","journal-title":"Children (Basel)"},{"issue":"05","key":"ref20","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jpedsurg.2020.07.028","article-title":"Esophageal substitution or esophageal elongation procedures in patients with complicated esophageal atresia? Results of a comparative study","volume":"56","author":"A CA Tannuri","year":"2021","journal-title":"J Pediatr Surg"},{"issue":"08","key":"ref21","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/pan.14204","article-title":"Associations of perioperative characteristics with motor function in preschool children born with esophageal atresia","volume":"31","author":"C E van Hoorn","year":"2021","journal-title":"Paediatr Anaesth"},{"issue":"03","key":"ref22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4103\/0971-9261.182588","article-title":"An assessment of quality of life of operated cases of esophageal atresia in the community","volume":"21","author":"H S Bal","year":"2016","journal-title":"J Indian Assoc Pediatr Surg"},{"issue":"01","key":"ref23","first-page":"61","article-title":"Transition of patients with esophageal atresia to adult care: results of a transition-specific education program","volume":"27","author":"J Dingemann","year":"2017","journal-title":"Eur J Pediatr Surg"},{"issue":"10","key":"ref24","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00383-017-4141-0","article-title":"Changes in quality of life from infancy to school age after esophagoesophagostomy for tracheoesophageal fistula: thoracotomy versus thoracoscopy","volume":"33","author":"G Miyano","year":"2017","journal-title":"Pediatr Surg Int"},{"issue":"03","key":"ref25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/SLA.0000000000002918","article-title":"Long-term quality of life in neonatal surgical disease","volume":"268","author":"R Amin","year":"2018","journal-title":"Ann Surg"},{"issue":"04","key":"ref26","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jpedsurg.2017.05.033","article-title":"A patient led, international study of long term outcomes of esophageal atresia: EAT 1","volume":"53","author":"E Svoboda","year":"2018","journal-title":"J Pediatr Surg"},{"issue":"52","key":"ref27","doi-asserted-by":"crossref","first-page":"e13801","DOI":"10.1097\/MD.0000000000013801","article-title":"Prospective evaluation of clinical outcomes and quality of life after gastric tube interposition as esophageal reconstruction in children","volume":"97","author":"J K Youn","year":"2018","journal-title":"Medicine (Baltimore)"},{"issue":"07","key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/dote\/dox017","article-title":"Development and pilot-testing of a condition-specific instrument to assess the quality-of-life in children and adolescents born with esophageal atresia","volume":"30","author":"M Dellenmark-Blom","year":"2017","journal-title":"Dis Esophagus"},{"issue":"S 03","key":"ref30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s13063-017-1978-4","article-title":"The COMET handbook: version 1.0","volume":"18","author":"P R Williamson","year":"2017","journal-title":"Trials"}],"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1758828.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T12:29:07Z","timestamp":1681302547000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1758828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":27,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2023,3,17]]},"published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1758828","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"value":"0939-7248","type":"print"},{"value":"1439-359X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,16]]}}}