{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:08:50Z","timestamp":1777896530456,"version":"3.51.4"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An outbreak of severe pneumonia of unknown cause was identified in Wuhan, China in December 2019: the causative agent was a novel betacoronavirus, severe acute respiratory syndrome-cotonavirus-2 (SARS-CoV-2), a virus that joins a list of coronaviruses causing severe (e.g., SARS and Middle East respiratory syndrome) or milder (e.g., 229E, OC43, NL63, and HKU1) respiratory tract infection. The World Health Organization (WHO) classified the spreading outbreak as a pandemic on March 11, 2020. Many SARS-related coronaviruses (SARSr-CoVs) have been identified in bats, particularly in Rhinolophus horseshoe bats, animals that are common in southern China and Southeast Asia. Many of the features of SARS-CoV-2 that facilitate human infection\u2014the furin cleavage site, the receptor binding domain that binds to the human ACE2 receptor\u2014can be identified in SARSr-CoVs. Related coronaviruses can be detected in pangolins and other animals, and human SARS-CoV-2 itself can infect various animals, some of which can transmit SARS-CoV-2 back to humans. Investigation by the WHO and others pointed to the initial outbreak being centered on the Huanan wet market in Wuhan where wild and farmed animals were sold, and where environmental testing revealed widespread SARS-CoV-2 contamination. This supports the hypothesis that bats, probably via an intermediate animal, are the origin of SARS-CoV-2. Other possible origins have been postulated, such as an accidental or deliberate laboratory leak, or virus present in frozen foods, but evidence for these ideas has not surfaced. Study of the origins of SARS-CoV-2 have been complicated by intense media and political commentary, features that may slow the studies required to understand the viral origins. Such studies are complex and may be slow: international openness and co-operation is vital. Origins explanations are needed to predict or prevent future pandemics and support the \u201cOne Health\u201d approach to disease.<\/jats:p>","DOI":"10.1055\/s-0042-1759564","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T23:35:55Z","timestamp":1673912155000},"page":"003-007","source":"Crossref","is-referenced-by-count":8,"title":["The Origins of Severe Acute Respiratory Syndrome-Coronavirus-2"],"prefix":"10.1055","volume":"44","author":[{"given":"Dominic E.","family":"Dwyer","sequence":"additional","affiliation":[{"name":"Public Health Pathology, New South Wales Health Pathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"N Zhu","year":"2020","journal-title":"N Engl J Med"},{"key":"ref5","volume-title":"Preparing for emerging zoonotic viruses. Encyclopedia of Virology","author":"R S Sikkema","year":"2021","edition":"4th ed."},{"issue":"20","key":"ref7","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1056\/NEJMoa030666","article-title":"A cluster of cases of severe acute respiratory syndrome in Hong Kong","volume":"348","author":"K W Tsang","year":"2003","journal-title":"N Engl J Med"},{"issue":"19","key":"ref8","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1056\/NEJMoa1211721","article-title":"Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia","volume":"367","author":"A M Zaki","year":"2012","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"C Huang","year":"2020","journal-title":"Lancet"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41579-021-00665-x","article-title":"Diversity and evolution of the animal virome","volume":"20","author":"E Harvey","year":"2022","journal-title":"Nat Rev Microbiol"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41591-020-0820-9","article-title":"The proximal origin of SARS-CoV-2","volume":"26","author":"K G Andersen","year":"2020","journal-title":"Nat Med"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41564-020-0771-4","article-title":"Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic","volume":"5","author":"M F Boni","year":"2020","journal-title":"Nat Microbiol"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.coviro.2012.11.006","article-title":"Bats and their virome: an important source of emerging viruses capable of infecting humans","volume":"3","author":"I Smith","year":"2013","journal-title":"Curr Opin Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.1118391","article-title":"Bats are natural reservoirs of SARS-like coronaviruses","volume":"310","author":"W Li","year":"2005","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"198024","DOI":"10.1016\/j.virusres.2020.198024","article-title":"Swine enteric alphacoronavirus (swine acute diarrhea syndrome coronavirus): an update three years after its discovery","volume":"285","author":"Y-L Yang","year":"2020","journal-title":"Virus Res"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1038\/s41467-020-17687-3","article-title":"Origin and cross-species transmission of bat coronaviruses in China","volume":"11","author":"A Latinne","year":"2020","journal-title":"Nat Commun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"P Zhou","year":"2020","journal-title":"Nature"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3390\/v11030210","article-title":"Bat coronaviruses in China","volume":"11","author":"Y Fan","year":"2019","journal-title":"Viruses"},{"issue":"23","key":"ref19","doi-asserted-by":"crossref","first-page":"11858","DOI":"10.1128\/JVI.01755-15","article-title":"Evidence for an ancestral association of human coronavirus 229E with bats","volume":"89","author":"V M Corman","year":"2015","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/bs.aivir.2018.01.001","article-title":"Hosts and sources of endemic human coronaviruses","volume":"100","author":"V M Corman","year":"2018","journal-title":"Adv Virus Res"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.3201\/eid1911.131172","article-title":"Middle East respiratory syndrome coronavirus in bats, Saudi Arabia","volume":"19","author":"Z A Memish","year":"2013","journal-title":"Emerg Infect Dis"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"e1006698","DOI":"10.1371\/journal.ppat.1006698","article-title":"Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus","volume":"13","author":"B Hu","year":"2017","journal-title":"PLoS Pathog"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.cub.2020.05.023","article-title":"A novel bat coronavirus closely related to SARS-CoV-2 contains natural insertions at the S1\/S2 cleavage site of the spike protein","volume":"30","author":"H Zhou","year":"2020","journal-title":"Curr Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/s41586-022-04464-z","article-title":"ACE2 binding is an ancestral and evolvable trait of sarbecoviruses","volume":"603","author":"T N Starr","year":"2022","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41586-020-2313-x","article-title":"Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins","volume":"583","author":"K Xiao","year":"2020","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41586-022-04532-4","article-title":"Bat coronaviruses related to SARS-CoV-2 and infectious for human cells","volume":"604","author":"S Temmam","year":"2022","journal-title":"Nature"},{"issue":"01","key":"ref27","doi-asserted-by":"crossref","first-page":"6563","DOI":"10.1038\/s41467-021-26809-4","article-title":"A novel SARS-CoV-2 related coronavirus in bats from Cambodia","volume":"12","author":"D Delaune","year":"2021","journal-title":"Nat Commun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41586-021-04353-x","article-title":"SARS-CoV-2 infection in free-ranging white-tailed deer","volume":"602","author":"V L Hale","year":"2022","journal-title":"Nature"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1038\/s41467-021-27096-9","article-title":"Adaptation, spread and transmission of SARS-CoV-2 in farmed minks and associated humans in the Netherlands","volume":"12","author":"L Lu","year":"2021","journal-title":"Nat Commun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1126\/science.abe5901","article-title":"Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans","volume":"371","author":"B B Oude Munnink","year":"2021","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/S0140-6736(22)00326-9","article-title":"Transmission of SARS-CoV-2 delta variant (AY.127) from pet hamsters to humans, leading to onward human-to-human transmission: a case study","volume":"399","author":"H-L Yen","year":"2022","journal-title":"Lancet"},{"issue":"17","key":"ref33","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1056\/NEJMoa032565","article-title":"Laboratory-acquired severe acute respiratory syndrome","volume":"350","author":"P L Lim","year":"2004","journal-title":"N Engl J Med"},{"issue":"19","key":"ref34","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1016\/j.cell.2021.08.017","article-title":"The origins of SARS-CoV-2: a critical review","volume":"184","author":"E C 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