{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:58:16Z","timestamp":1781179096853,"version":"3.54.1"},"reference-count":30,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Background and Aims\u2003Gastric cancer is the third most common cause of cancer-related mortality worldwide after lungs and colorectum. Although controversial, Her2neu overexpression by immunohistochemistry is usually associated with poor prognosis in patients with carcinoma stomach. We conducted a prospective study to evaluate the prognostic role of Her2neu and its correlation with clinical, pathologic type, and stage of the disease.<\/jats:p>\n                  <jats:p>Methods\u2003A prospective study was performed on paraffin blocks of 111 gastric cancer specimens (88 patients were biopsy specimens and 23 were gastrectomy specimens). The paraffin blocks were processed for Her2neu receptor immunohistochemical staining and fluorescence in situ hybridization, and scoring was done.<\/jats:p>\n                  <jats:p>Results\u2003Her2neu overexpression was detected in 30 out of 111 (27%) patients. The mean age was 57.68\u2009\u00b1\u200912.82 years, with males constituting two-thirds of total patients. Tobacco addiction was found in 44% of the patients and smoking in 33% of the patients. Her2neu expression was similar in Lauren's intestinal and diffuse histologic type; however, proximal gastric tumors overexpressed Her2neu as compared with distal tumors. Her2neu 2+ or 3\u2009+\u2009(odds ratio: 2.52, 95% CI: 1.61\u20133.95, p\u2009=\u20090.001) was the only independent predictor of survival in gastric cancer patients. Kaplan\u2013Meir survival analysis showed that the survival of gastric cancer patients with Her2neu overexpression (Her2neu 2+ or 3\u2009+\u2009) was significantly lower than that of those with Her2neu nonexpression (p\u2009=\u20090.001).<\/jats:p>\n                  <jats:p>Conclusion\u2003Her2neu positivity was a significant predictor of mortality in patients with carcinoma stomach, and Her2neu overexpression was associated with a lower overall survival rate compared with Her2neu nonexpression.<\/jats:p>","DOI":"10.1055\/s-0042-1759601","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T19:04:35Z","timestamp":1677783875000},"page":"135-140","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological Significance and Prognostic Role of Her2neu Protein Expression in Patients with Carcinoma Stomach: A Prospective Study from Northern India"],"prefix":"10.25259","volume":"12","author":[{"given":"Abhilash V.","family":"B.","sequence":"additional","affiliation":[{"name":"ESIC Hospital, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manas Kumar","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Srirama Chandra Bhanja (SCB) Medical College, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashikant C. U.","family":"Patne","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunit Kumar","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod Kumar","family":"Dixit","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"issue":"01","key":"ref1","first-page":"26","article-title":"Epidemiology of gastric cancer: global trends, risk factors and prevention","volume":"14","author":"P Rawla","year":"2019","journal-title":"Prz Gastroenterol"},{"issue":"01","key":"ref2","first-page":"10","article-title":"Estimate of cancer incidence in India in 1991","volume":"35","author":"D N Rao","year":"1998","journal-title":"Indian J Cancer"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/0971-5851.81884","article-title":"Gastric cancer in India","volume":"32","author":"A Sharma","year":"2011","journal-title":"Indian J Med Paediatr Oncol"},{"issue":"02","key":"ref4","first-page":"74","article-title":"Epidemiology of digestive tract cancers in India. VI. Projected burden in the new millennium and the need for primary prevention","volume":"19","author":"K M Mohandas","year":"2000","journal-title":"Indian J Gastroenterol"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0971-5851.81883","article-title":"Epidemiological review of gastric cancer in India","volume":"32","author":"R P Dikshit","year":"2011","journal-title":"Indian J Med Paediatr Oncol"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s101200200042","article-title":"Gastric cancer in India","volume":"5","author":"K Pavithran","year":"2002","journal-title":"Gastric Cancer"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1136\/gut.8.4.361","article-title":"Geographical distribution of gastrointestinal cancers in India with special reference to causation","volume":"8","author":"S L Malhotra","year":"1967","journal-title":"Gut"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3748\/wjg.v17.i11.1501","article-title":"Clinicopathologic significance of HER-2\/neu protein expression and gene amplification in gastric carcinoma","volume":"17","author":"S Y Yan","year":"2011","journal-title":"World J Gastroenterol"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/IJPM.IJPM_835_19","article-title":"Role of HER2neu expression in gastric cancer","volume":"64","author":"J S Sukanya","year":"2021","journal-title":"Indian J Pathol Microbiol"},{"key":"ref10","first-page":"868645","article-title":"Immunohistochemical biomarkers in gastric cancer research and management","volume":"2012","author":"E Lastraioli","year":"2012","journal-title":"Int J Surg Oncol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0140-6736(10)61121-X","article-title":"Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial","volume":"376","author":"Y J Bang","year":"2010","journal-title":"Lancet"},{"issue":"07","key":"ref12","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1365-2559.2008.03028.x","article-title":"Assessment of a HER2 scoring system for gastric cancer: results from a validation study","volume":"52","author":"M Hofmann","year":"2008","journal-title":"Histopathology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5592376","DOI":"10.1155\/2021\/5592376","article-title":"Diastolic dysfunction is a predictor of poor survival in patients with decompensated cir-rhosis","volume":"2021","author":"M K Behera","year":"2021","journal-title":"Int J Hepatol"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S2468-1253(19)30328-0","article-title":"The global, regional, and national burden of stomach cancer in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease study 2017","volume":"5","author":"GBD 2017 Stomach Cancer Collaborators","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.31557\/APJCP.2019.20.4.1139","article-title":"Prevalence of HER2 expression and its correlation with clinicopathological parameters in gastric or gastroesophageal junction adenocarcinoma in North-East Indian population","volume":"20","author":"P S Roy","year":"2019","journal-title":"Asian Pac J Cancer Prev"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1365-3083.1994.tb03401.x","article-title":"Significance of erbB-2 gene product as a target molecule for cancer therapy","volume":"39","author":"T Ishida","year":"1994","journal-title":"Scand J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/1097-0142(19950315)75:6+<1418::AID-CNCR2820751505>3.0.CO;2-Y","article-title":"Clinical significance of epidermal growth factor (EGF), EGF receptor, and c-erbB-2 in human gastric cancer","volume":"75","author":"A Tokunaga","year":"1995","journal-title":"Cancer"},{"issue":"02","key":"ref18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/annonc\/mdi064","article-title":"Amplification of HER-2 in gastric carcinoma: association with topoisomerase II alpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab","volume":"16","author":"M Tanner","year":"2005","journal-title":"Ann Oncol"},{"issue":"07","key":"ref19","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/annonc\/mdt106","article-title":"Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT-0116\/SWOG9008 clinical trial","volume":"24","author":"M A Gordon","year":"2013","journal-title":"Ann Oncol"},{"issue":"08","key":"ref20","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s10620-005-9057-1","article-title":"HER-2\/neu amplification is an independent prognostic factor in gastric cancer","volume":"51","author":"D I Park","year":"2006","journal-title":"Dig Dis Sci"},{"issue":"03","key":"ref21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12664-012-0214-0","article-title":"HER2 expression in gastric cancer in Indian population\u2014an immunohistochemistry and fluorescence in situ hybridization study","volume":"31","author":"A Sekaran","year":"2012","journal-title":"Indian J Gastroenterol"},{"issue":"14","key":"ref22","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.3748\/wjg.v19.i14.2171","article-title":"Correlation of human epidermal growth factor receptor 2 expression with clinicopathological characteristics and prognosis in gastric cancer","volume":"19","author":"C He","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1002\/1097-0142(19931201)72:11<3179::AID-CNCR2820721108>3.0.CO;2-#","article-title":"Overexpression of c-erbB-2 protein in gastric cancer. Its correlation with long-term survival of patients","volume":"72","author":"S Uchino","year":"1993","journal-title":"Cancer"},{"issue":"05","key":"ref24","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/jcp.45.5.454","article-title":"c-erbB-2 oncogene product expression and prognosis in gastric carcinoma","volume":"45","author":"D A Hilton","year":"1992","journal-title":"J Clin Pathol"},{"issue":"06","key":"ref25","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/BF01629433","article-title":"Expression of Her2\/neu oncogene product p185 in correlation to clinicopathological and prognostic factors of gastric carcinoma","volume":"118","author":"J Jaehne","year":"1992","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s00508-011-0025-9","article-title":"Prognostic significance of HER2\/neu expression in gastric cancer","volume":"123","author":"J Ananiev","year":"2011","journal-title":"Wien Klin Wochenschr"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1007\/s00268-009-0142-z","article-title":"Comparative study on overexpression of HER2\/neu and HER3 in gastric cancer","volume":"33","author":"X L Zhang","year":"2009","journal-title":"World J Surg"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00432-009-0574-8","article-title":"Overexpression of Grb2\/HER2 signaling in Chinese gastric cancer: their relationship with clinicopathological parameters and prognostic significance","volume":"135","author":"G Z Yu","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"issue":"06","key":"ref29","first-page":"943","article-title":"HER 2\/neu protein expression in gastric cancer is associated with poor survival","volume":"2","author":"S D Xie","year":"2009","journal-title":"Mol Med Rep"},{"issue":"09","key":"ref30","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/annonc\/mdn169","article-title":"HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target","volume":"19","author":"C Gravalos","year":"2008","journal-title":"Ann Oncol"}],"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1759601.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:12:43Z","timestamp":1781176363000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/clinicopathological-significance-and-prognostic-role-of-her2neu-protein-expression-in-patients-with-carcinoma-stomach-a-prospective-study-from-northern-india\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,2]]},"references-count":30,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2023,11,9]]},"published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1759601","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,2]]}}}