{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:15:10Z","timestamp":1787004910667,"version":"build-2736575974"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hurthle cell thyroid carcinoma (HCTC) demonstrates inferior prognosis compared with other types of differentiated thyroid cancer (DTC), along with radioiodine refractoriness and relatively poor 131I concentrating ability. We herein report a case of a middle-aged lady presenting with neck swelling for years, who on pre-surgery work-up was diagnosed to harbor metastatic nodal and lung lesions. Post-thyroidectomy and neck dissection, she was diagnosed with HCTC. Post-surgery, none of the lesions concentrated radioactive-iodine (RAI) sufficiently but showed FDG avid lesions as mediastinal nodes, lung nodules, solitary lytic sternal lesions, and unusual bilateral paraaortic abdominal nodes. She was put on tyrosine kinase inhibitor (sorafenib) and showed disease stabilization for the initial 3 years, but multiple toxicity symptoms while on sorafenib therapy that needed multiple dose adjustments. Over the period of the subsequent year, she developed significant disease progression with liver involvement. She was shifted to lenvatinib, which she tolerated well. The functional imaging profile with unusual metastatic sites, the aggressive clinical presentation and disease course of RAI refractory HCTC over 4 years on tyrosine kinase inhibitor therapy, and the role of molecular FDG-PET\/CT imaging in disease monitoring and clinical management of such case is presented.<\/jats:p>","DOI":"10.1055\/s-0042-1759615","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T19:34:57Z","timestamp":1671564897000},"page":"070-074","source":"Crossref","is-referenced-by-count":3,"title":["Hurthle Cell Thyroid Carcinoma with Liver and Paraaortic Abdominal Nodal Metastasis: Progression on Sorafenib Therapy after Initial Disease Stabilization"],"prefix":"10.1055","volume":"22","author":[{"given":"Sarvesh","family":"Loharkar","sequence":"additional","affiliation":[{"name":"Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Parel, Mumbai, Maharashtra, India"},{"name":"Homi Bhabha National Institute, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Basu","sequence":"additional","affiliation":[{"name":"Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Parel, Mumbai, Maharashtra, India"},{"name":"Homi Bhabha National Institute, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/cncr.27770","article-title":"Hurthle cell carcinoma: a population-level analysis of 3311 patients","volume":"119","author":"P Goffredo","year":"2013","journal-title":"Cancer"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1001\/archotol.129.2.207","article-title":"Survival and prognosis in H\u00fcrthle cell carcinoma of the thyroid gland","volume":"129","author":"N Bhattacharyya","year":"2003","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/03007995.2017.1368466","article-title":"Tyrosine kinase inhibitors for advanced or metastatic thyroid cancer: a meta-analysis of randomized controlled trials","volume":"34","author":"J W Liu","year":"2018","journal-title":"Curr Med Res Opin"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12885-016-2179-3","article-title":"Treatment and outcome of 32 patients with distant metastases of H\u00fcrthle cell thyroid carcinoma: a single-institution experience","volume":"16","author":"N Besic","year":"2016","journal-title":"BMC Cancer"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1089\/thy.2009.0019","article-title":"Intra-abdominal insular thyroid carcinoma metastasis","volume":"19","author":"G Y Meyer-Rochow","year":"2009","journal-title":"Thyroid"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s40792-020-00959-x","article-title":"Anaplastic transformation of thyroid cancer in mesentery metastases presenting as intestinal perforation: a case report","volume":"6","author":"K Hosoda","year":"2020","journal-title":"Surg Case Rep"},{"issue":"08","key":"ref7","first-page":"1260","article-title":"Diagnostic accuracy and prognostic value of 18F-FDG PET in H\u00fcrthle cell thyroid cancer patients","volume":"47","author":"D A Pryma","year":"2006","journal-title":"J Nucl Med"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"e19408","DOI":"10.1097\/MD.0000000000019408","article-title":"Rapid disease progression after discontinuation of lenvatinib in thyroid cancer","volume":"99","author":"H Yamazaki","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"08","key":"ref9","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3390\/cancers11081185","article-title":"Targeted treatment options of recurrent radioactive iodine refractory H\u00fcrthle cell cancer","volume":"11","author":"M D Aydemirli","year":"2019","journal-title":"Cancers (Basel)"}],"container-title":["World Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1759615.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T07:53:37Z","timestamp":1681286017000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1759615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":9,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,3,13]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1759615","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1450-1147","1607-3312"],"issn-type":[{"value":"1450-1147","type":"print"},{"value":"1607-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,20]]}}}