{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:14:50Z","timestamp":1762377290947,"version":"3.37.3"},"reference-count":28,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"11","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003The use of granulocyte macrophage colony-stimulating factor (GM-CSF)-containing medium, which is a commercial medium that is used for cultivation of embryos in in vitro fertilization (IVF) treatments, has been suggested to increase the efficiency of this procedure in patients with previous multiple unsuccessful attempts. In this retrospective study, we analyzed GM-CSF-containing embryo culture media compared with traditional culture media in terms of development of embryos, pregnancy, and ongoing pregnancy success and live birth rates.<\/jats:p><jats:p>\n          Methods\u2003This is a prospective case control study conducted in a single center. A total of 131 unexplained infertility patients were included in the study. A cohort of 69 patients whose embryos were cultured in GM-CSF-containing medium and a control group of 62 age-matched patients whose embryos were cultured in conventional Sage One Step medium were included in the study. The major study outcomes were achievement of pregnancy and ongoing pregnancy rate at 12 weeks of gestation.<\/jats:p><jats:p>\n          Results\u2003The pregnancy and ongoing pregnancy rates of the patients whose embryos were cultured in GM-CSF-containing medium were 39.13% and 36.23%, respectively. These were higher than the rates of the control group, which were 30.65% and 29.03%, respectively, although this difference was not statistically significant. In addition, the 5th-day embryo transfer percentage in the GM-CSF group was higher than in the control group (34.78% versus 27.4%).<\/jats:p><jats:p>\n          Conclusion\u2003The main findings of our study were that there was no difference between the GM-CSF-enhanced medium and the control group in terms of our major study outcomes. However, blastomere inequality rate and embryo fragmentation rates were lower in the GM-CSF group.<\/jats:p>","DOI":"10.1055\/s-0042-1759630","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T23:42:17Z","timestamp":1672357337000},"page":"1047-1051","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of the Effects of GMCSF-Containing and Traditional Culture Media on Embryo Development and Pregnancy Success Rates"],"prefix":"10.61622","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-6296","authenticated-orcid":false,"given":"Fatih","family":"Adanac\u0131oglu","sequence":"additional","affiliation":[{"name":"Turan Cetin Private IVF Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-592X","authenticated-orcid":false,"given":"\u00c7a\u011flar","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bezmialem Vakif University School of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6084-4043","authenticated-orcid":false,"given":"Gozde","family":"Tokat","sequence":"additional","affiliation":[{"name":"Department of Embryology, Turan Cetin Private IVF Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4578-0939","authenticated-orcid":false,"given":"Durdane","family":"Adanac\u0131oglu","sequence":"additional","affiliation":[{"name":"Adana State Hospital, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7480-4691","authenticated-orcid":false,"given":"Ayse Filiz Gokmen","family":"Karasu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bezmialem Vakif University School of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-4882","authenticated-orcid":false,"given":"Mehmet Turan","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Turan Cetin Private IVF Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1007\/s10815-012-9861-4","article-title":"Assessment and treatment of repeated implantation failure (RIF)","volume":"29","author":"A Simon","year":"2012","journal-title":"J Assist Reprod Genet"},{"issue":"06","key":"ref2","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1055\/s-2007-991044","article-title":"Uterine receptivity: alterations associated with benign gynecological disease","volume":"25","author":"M Donaghay","year":"2007","journal-title":"Semin Reprod 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