{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:00Z","timestamp":1740126840093,"version":"3.37.3"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003Studies exploring the relationship between neonatal abstinence syndrome (NAS) and congenital anomalies (CA) in the United States are limited given the small sample size or data prior to the opioid epidemic. We aimed to determine if there is an association between NAS and CA in a nationally representative cohort of newborn hospitalization in the United States.<\/jats:p><jats:p>\n            Study Design\u2003This was a cross-sectional analysis of NAS-related hospitalizations within the 2016 Kids Inpatient Database. International Classification of Diseases (ICD-10-CM) diagnostic codes were used to identify NAS hospitalizations and those with and without CA. The primary outcome was the odds of CAs in NAS hospitalizations. Multivariate survey logistic regression was used to analyze the relationship between NAS and CA.<\/jats:p><jats:p>\n            Results\u2003Among 3.7 million newborn hospitalizations, 25,394 had NAS (6.7 per 1,000). The prevalence of any CA was higher in those with NAS when compared with non-NAS hospitalizations (10.3 vs. 4.9%; odds ratio\u2009=\u20092.27; 95% confidence interval [CI]: 2.13\u20132.43). Adjusted analysis showed similar results (adjusted odds ratio:\u2009=\u20091.83, CI: 1.71\u20131.95). NAS hospitalizations with CA had a higher mortality rate (0.6 vs 0.04%, p\u2009&lt;\u20090.0001) and higher resource use.<\/jats:p><jats:p>\n            Conclusion\u2003This nationwide study shows that NAS may be associated with increased odds of CAs, suggesting that NAS may be a risk factor for increased morbidity in the newborn period.<\/jats:p><jats:p>\n            Key points\n          <\/jats:p>","DOI":"10.1055\/s-0042-1759864","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T23:34:06Z","timestamp":1672097646000},"page":"e1023-e1029","source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["Association between Neonatal Abstinence Syndrome and Congenital Anomalies in the United States"],"prefix":"10.1055","volume":"41","author":[{"given":"Parth","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, United Hospital Center, Bridgeport, West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Ampem-Darko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tema General Hospital, Tema, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace Annan","family":"Cudjoe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Ghana School of Medicine and Dentistry, Accra, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narendrasinh","family":"Parmar","sequence":"additional","affiliation":[{"name":"Section of Emergency Medicine, East Tennessee Children's Hospital, Knoxville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igbagbosanmi","family":"Oredein","sequence":"additional","affiliation":[{"name":"Pediatric Residency Program, Hurley Medical Center, Flint, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adwoa O.","family":"Asiama","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pantang Hospital, Accra, Greater Accra, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenil","family":"Patel","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Population Health, School of Public Health, University of Texas Health Science Center at Houston (UT Health), Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahithi","family":"Pemmasani","sequence":"additional","affiliation":[{"name":"Pediatric Residency Program, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay Gandhi","family":"Linga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, San Juan Regional Medical Center, Farmington, New Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyur","family":"Donda","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of South Florida, Tampa, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshit","family":"Doshi","sequence":"additional","affiliation":[{"name":"Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-0437","authenticated-orcid":false,"given":"Fredrick","family":"Dapaah-Siakwan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Valley Children's Hospital, Madera, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"e547","DOI":"10.1542\/peds.2013-3524","article-title":"Neonatal abstinence syndrome","volume":"134","author":"P Kocherlakota","year":"2014","journal-title":"Pediatrics"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"314.e1","DOI":"10.1016\/j.ajog.2010.12.039","article-title":"Maternal treatment with opioid analgesics and risk for birth defects","volume":"204","author":"C S Broussard","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.15288\/jsad.2018.79.553","article-title":"Correlation of neonatal abstinence syndrome with risk of birth defects and infant morbidity","volume":"79","author":"N Auger","year":"2018","journal-title":"J Stud Alcohol 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