{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:31:10Z","timestamp":1780104670306,"version":"3.54.0"},"reference-count":91,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nontuberculous mycobacteria (NTM) are a group of mycobacteria which represent opportunistic pathogens that are of increasing concern in people with cystic fibrosis (pwCF). The acquisition has been traditionally though to be from environmental sources, though recent work has suggested clustered clonal infections do occur and transmission potential demonstrated among pwCF attending CF specialist centers. Guidelines for the screening, diagnosis, and identification of NTM and management of pwCF have been published. The emergence of CF-specific therapies, in particular cystic fibrosis transmembrane regulator (CFTR) modulator drugs, have led to significant improvement in the health and well-being of pwCF and may lead to challenges in sampling the lower respiratory tract including to screen for NTM. This review highlights the epidemiology, modes of acquisition, screening and diagnosis, therapeutic approaches in the context of improved clinical status for pwCF, and the clinical application of CFTR modulator therapies.<\/jats:p>","DOI":"10.1055\/s-0042-1759883","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T03:50:49Z","timestamp":1674013849000},"page":"287-296","source":"Crossref","is-referenced-by-count":6,"title":["Nontuberculous Mycobacteria in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Regulator Modulators"],"prefix":"10.1055","volume":"44","author":[{"given":"Andrew","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, The Prince Charles Hospital, Chermside, Queensland, Australia"},{"name":"Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Thomson","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, The Prince Charles Hospital, Chermside, Queensland, Australia"},{"name":"Gallipoli Medical Research Foundation, Greenslopes Private Hospital, Greenslopes, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E.","family":"Wainwright","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Australia"},{"name":"Children's Health Research Centre, Faculty of Medicine, The University of Queensland, South Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, The Prince Charles Hospital, Chermside, Queensland, Australia"},{"name":"Children's Health Research Centre, Faculty of Medicine, The University of Queensland, South Brisbane, Australia"},{"name":"Translational Research Institute, Woolloongabba, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.3389\/fphar.2019.01662","article-title":"CFTR modulators: the changing face of cystic fibrosis in the era of precision medicine","volume":"10","author":"M Lopes-Pacheco","year":"2020","journal-title":"Front Pharmacol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1002\/ppul.25733","article-title":"Increasing life expectancy in cystic fibrosis: advances and challenges","volume":"57","author":"K A McBennett","year":"2022","journal-title":"Pediatr Pulmonol"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3390\/genes11060589","article-title":"The changing epidemiology of cystic fibrosis: incidence, survival and impact of the CFTR gene 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Dis"},{"key":"ref13","volume-title":"ECFS Patient Registry Annual Data Report 2018","author":"A Zolin","year":"2020"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jcf.2019.08.006","article-title":"Changing epidemiology of the respiratory bacteriology of patients with cystic fibrosis-data from the European cystic fibrosis society patient registry","volume":"19","author":"E Hatziagorou","year":"2020","journal-title":"J Cyst Fibros"},{"key":"ref15","first-page":"1","article-title":"[Italian Cystic Fibrosis Registry (ICFR). 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Radiol"},{"issue":"05","key":"ref53","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1128\/JCM.02423-16","article-title":"Evaluation of RGM medium for isolation of nontuberculous mycobacteria from respiratory samples from patients with cystic fibrosis in the United States","volume":"55","author":"R Plongla","year":"2017","journal-title":"J Clin Microbiol"},{"issue":"07","key":"ref54","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1128\/JCM.00471-16","article-title":"Evaluation of various culture media for detection of rapidly growing mycobacteria from patients with cystic fibrosis","volume":"54","author":"C L Preece","year":"2016","journal-title":"J Clin Microbiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jctube.2018.07.003","article-title":"Comparison of the RGM medium and the mycobacterial growth indicator tube automated system for isolation of non-tuberculous mycobacteria from sputum samples of cystic fibrosis patients in 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Ravnholt","year":"2019","journal-title":"J Cyst Fibros"},{"issue":"03","key":"ref62","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1183\/09031936.00011815","article-title":"Serodiagnosis of Mycobacterium abscessus complex infection in cystic fibrosis","volume":"46","author":"T Qvist","year":"2015","journal-title":"Eur Respir J"},{"issue":"03","key":"ref63","doi-asserted-by":"crossref","first-page":"e0019222","DOI":"10.1128\/spectrum.00192-22","article-title":"IgA serological response for the diagnosis of Mycobacterium abscessus infections in patients with cystic fibrosis","volume":"10","author":"V Le Moigne","year":"2022","journal-title":"Microbiol Spectr"},{"issue":"02","key":"ref64","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jcf.2021.08.019","article-title":"Serological biomarkers for the diagnosis of Mycobacterium abscessus infections in cystic fibrosis patients","volume":"21","author":"V Le Moigne","year":"2022","journal-title":"J Cyst 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