{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T22:42:03Z","timestamp":1776811323235,"version":"3.51.2"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In 873 propensity score\u2013matched pairs of patients undergoing valvular heart surgery, we compared a \u201cmoderate dose\u201d of tranexamic acid (TXA) protocol (group 1; median TXA dose: 24\u2009mg\/kg body weight) with a 1.5-g \u201cbolus-only\u201d protocol (group 2; median TXA dose: 19\u2009mg\/kg body weight). The number of transfused patients was higher in group 2 than in group 1 (74.5 vs 66.0%, p\u2009&lt;\u20090.001), as was the number of transfused red blood cell concentrates (p\u2009=\u20090.001). The risks of re-exploration and convulsive seizures were similar between groups (p\u2009&gt;\u20090.50). Data indicate an impaired efficacy following the \u201cbolus-only\u201d protocol, without a significant safety improvement.<\/jats:p>","DOI":"10.1055\/s-0042-1760205","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T23:40:26Z","timestamp":1674171626000},"page":"055-058","source":"Crossref","is-referenced-by-count":3,"title":["The Efficacy and Safety of a Low-Dose Tranexamic Acid Bolus-Only Protocol Compared with the Moderate-Dose Protocol in Valvular Heart Surgery"],"prefix":"10.1055","volume":"72","author":[{"given":"Andreas","family":"Koster","sequence":"additional","affiliation":[{"name":"Institute for Anesthesiology and Pain Therapy, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolai","family":"Hulde","sequence":"additional","affiliation":[{"name":"Institute for Anesthesiology and Pain Therapy, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus-Andre","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan F.","family":"Gummert","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"von Dossow","sequence":"additional","affiliation":[{"name":"Institute for Anesthesiology and Pain Therapy, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6085-6554","authenticated-orcid":false,"given":"Armin","family":"Zittermann","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/ALN.0000000000003633","article-title":"Exposure-response relationship of tranexamic acid in cardiac surgery","volume":"134","author":"P J Zufferey","year":"2021","journal-title":"Anesthesiology"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ana.24558","article-title":"Tranexamic acid-associated seizures: causes and treatment","volume":"79","author":"I Lecker","year":"2016","journal-title":"Ann Neurol"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1055\/s-0041-1724035","article-title":"Moderate dose of tranexamic acid and complications after valvular heart surgery","volume":"71","author":"N Hulde","year":"2023","journal-title":"Thorac Cardiovasc Surg"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1213\/ANE.0000000000002724","article-title":"Tranexamic acid dosing for cardiac surgical patients with chronic renal dysfunction: a new dosing regimen","volume":"127","author":"A Jerath","year":"2018","journal-title":"Anesth Analg"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MBC.0000000000000789","article-title":"What concentration of tranexamic acid is needed to inhibit fibrinolysis? 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