{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:45:48Z","timestamp":1793832348877,"version":"4.6.1"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n            Background\u2003Hormonal exposure leads to an increased risk of venous thromboembolism (VTE) but the risk of VTE associated with assisted reproductive technology (ART) is not clearly determined.<\/jats:p><jats:p>\n            Methods\u2003We searched in PubMed, EMBASE, Web of Science, and the Cochrane Library databases and identified all relevant articles published up to February 1, 2021. The primary objective was to determine the frequency of VTE associated with ART. Secondary objectives were to determine (1) the risk of VTE associated with ART as compared to pregnancy without ART; (2) the risk of VTE associated with ovarian hyperstimulation syndrome (OHSS); and (3) to determine potential risk factors of VTE related to ART.<\/jats:p><jats:p>\n            Results\u2003Fourteen studies were included. The overall frequency of VTE associated with ART was 0.23% (95% confidence interval [CI]: 0.07\u20130.46). Women undergoing ART had a two- to threefold increased risk of VTE as compared to spontaneous pregnancy (relative risk [RR]: 2.66; 95% CI: 1.60\u20134.43). The overall frequency of VTE specifically related to OHSS was &lt;0.001%. The risk of VTE after ART complicated by OHSS, as compared to ART without OHSS, was higher but not statistically significant (RR: 14.83; 95% CI: 0.86\u2013255.62). Risk factors of VTE associated with ART were in vitro fertilization procedure (RR, odds ratio [OR], and hazard ratio varying from 1.77, 95% CI: 1.41\u20132.23 to 4.99, 95% CI: 1.24\u201320.05), hyperhomocysteinemia (OR: 15.2; 95% CI: 2.0\u2013115.0), polycystic ovarian syndrome (PCOS) (RR: 4.8; 95% CI: 1.7\u201313.4), successful ART leading to pregnancy (OR: 13.94; 95% CI: 1.41\u2013137.45).<\/jats:p><jats:p>\n            Conclusion\u2003Further large prospective studies on risk factors of VTE in women undergoing ART are needed in order to optimize thromboprophylaxis in this context.<\/jats:p>","DOI":"10.1055\/s-0042-1760255","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T05:42:51Z","timestamp":1672638171000},"page":"283-294","source":"Crossref","is-referenced-by-count":30,"title":["Venous Thromboembolism Associated with Assisted Reproductive Technology: A Systematic Review and Meta-analysis"],"prefix":"10.1055","volume":"123","author":[{"given":"Marianne","family":"Goualou","sequence":"additional","affiliation":[{"name":"Internal and Vascular Medicine and Pulmonology Department, CHU Brest, Brest, France"},{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Noumegni","sequence":"additional","affiliation":[{"name":"Internal and Vascular Medicine and Pulmonology Department, CHU Brest, Brest, France"},{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"de Moreuil","sequence":"additional","affiliation":[{"name":"Internal and Vascular Medicine and Pulmonology Department, CHU Brest, Brest, France"},{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Le Guillou","sequence":"additional","affiliation":[{"name":"Gynecology Department, CHU Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"De Coninck","sequence":"additional","affiliation":[{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Internal and Vascular Medicine and Pulmonology Department, CHU Brest, Brest, France"},{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"},{"name":"F-CRIN INNOVTE, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Robin","sequence":"additional","affiliation":[{"name":"Internal and Vascular Medicine and Pulmonology Department, CHU Brest, Brest, France"},{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"},{"name":"F-CRIN INNOVTE, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Morcel","sequence":"additional","affiliation":[{"name":"Gynecology Department, CHU Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Le Moigne","sequence":"additional","affiliation":[{"name":"Internal and Vascular Medicine and Pulmonology Department, CHU Brest, Brest, France"},{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"},{"name":"F-CRIN INNOVTE, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Tremouilhac","sequence":"additional","affiliation":[{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"},{"name":"Gynecology Department, CHU Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Merviel","sequence":"additional","affiliation":[{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"},{"name":"Gynecology Department, CHU Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Le Mao","sequence":"additional","affiliation":[{"name":"Internal and Vascular Medicine and Pulmonology Department, CHU Brest, Brest, France"},{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Leroyer","sequence":"additional","affiliation":[{"name":"Internal and Vascular Medicine and Pulmonology Department, CHU Brest, Brest, France"},{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"},{"name":"F-CRIN INNOVTE, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bou\u00e9e","sequence":"additional","affiliation":[{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"},{"name":"Gynecology Department, CHU Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Couturaud","sequence":"additional","affiliation":[{"name":"Internal and Vascular Medicine and Pulmonology Department, CHU Brest, Brest, France"},{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"},{"name":"F-CRIN INNOVTE, Saint-Etienne, France"},{"name":"Centre d'investigation clinique INSERM 1412, University Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Tromeur","sequence":"additional","affiliation":[{"name":"Internal and Vascular Medicine and Pulmonology Department, CHU Brest, Brest, France"},{"name":"INSERM U1304 Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), University Brest, Brest, France"},{"name":"F-CRIN INNOVTE, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,12,31]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/humrep\/dey242","article-title":"ART in Europe, 2014: results generated from European registries by ESHRE: the European IVF-monitoring Consortium (EIM) for the European Society 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