{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:23:03Z","timestamp":1787736183847,"version":"build-2784847793"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Radiol Imaging"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Articular cartilage (AC) loss and deterioration, as well as bone remodeling, are all symptoms of osteoarthritis (OA). As a result, an ideal imaging technique for researching OA is required, which must be sensitive to both soft tissue and bone health.<\/jats:p><jats:p>\n          Objective\u2003The aim of this study was to assess the potential of simultaneous 18F sodium fluoride (18F-NaF) positron emission tomography\/magnetic resonance imaging (PET\/MRI) to identify as well as classify osseous metabolic abnormalities in knee OA and to see if degenerative changes in the cartilage and bone on MRI might be correlated with subchondral 18F-NaF uptake on PET.<\/jats:p><jats:p>\n          Methods\u2003Sixteen (32 knees) volunteers with no past history of knee injury, with or without pain, were enrolled for the research from January to July 2021. The images of both knees were taken utilizing an molecular magnetic resonance (mMR) body matrix coil on a simultaneous PET\/MRI biograph mMR. The acquisition was conducted after 45\u2009minutes of intravenous infusion of 18F-NaF 185\u2013370 MBq (5\u201310 mCi) over one PET bed for 40\u2009minutes, while MRI sequences were performed simultaneously.<\/jats:p><jats:p>\n          Results\u2003All pathologies showed significantly higher maximum standardized uptake value (SUVmax) than the background. Thirty-four subchondral magic spots were identified on 18F-NaF PET without any structural alteration on MRI. Bone marrow lesions (BMLs) and osteophytes with higher MRI osteoarthritis knee score (MOAKS) score showed higher 18F-NaF uptake (grade1\u02c2grade2\u02c2grade3). BMLs had corresponding AC degeneration. There was discordance between grade 1 osteophytes (86.6%), sclerosis (53.7%) and grade 1 BML in cruciate ligament insertion site (91.66%); they did not have high uptake of 18F-NaF. In case of cartilage, there was significant difference between AC grades and average subchondral SUVmax and T2* relaxometry (grade0\u02c2grade1\u02c2grade2\u02c2grade3\u02c2grade4). BMLs are much more metabolically active than other pathologies, while sclerosis is the least. We also found that the subchondral uptake was statistically increased in the areas of pathology:<\/jats:p><jats:p>\n          Conclusion\u200318F-NaF PET\/MRI was able to detect knee abnormalities unseen on MRI alone and simultaneously assessed metabolic and structural markers of knee OA across multiple tissues in the joint. Thus, it is a promising tool for detection of early metabolic changes in OA.<\/jats:p>","DOI":"10.1055\/s-0042-1760285","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T23:48:15Z","timestamp":1673048895000},"page":"173-182","source":"Crossref","is-referenced-by-count":11,"title":["Qualitative and Quantitative Evaluation of Morpho-Metabolic Changes in Bone Cartilage Complex of Knee Joint in Osteoarthritis Using Simultaneous 18F-NaF PET\/MRI\u2014A Pilot Study"],"prefix":"10.1055","volume":"33","author":[{"given":"Amarnath","family":"Jena","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging, Indraprastha Apollo Hospitals, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prerana","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospital, New Delhi, India"},{"name":"Apollo Hospitals Education and Research Foundation, Indraprastha Apollo Hospitals, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Taneja","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Vaish","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Joint Replacement Surgery, Indraprastha Apollo Hospitals, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Botchu","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Radiology, Royal Orthopedic Hospital, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju","family":"Vaishya","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Joint Replacement Surgery, Indraprastha Apollo Hospitals, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"issue":"10","key":"ref1","first-page":"20918","article-title":"Osteoarthritis in India: an epidemiologic aspect","volume":"8","author":"C S Azad","year":"2017","journal-title":"Int J Recent Sci Res"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.joca.2011.02.011","article-title":"MRI-based extended ordered values more efficiently differentiate cartilage loss in knees with and without joint space narrowing than region-specific approaches using MRI or radiography\u2013data from the OA 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