{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T11:03:50Z","timestamp":1780743830965,"version":"3.54.1"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003This study aimed to evaluate the effects of topical application of Acanthus ilicifolius methanolic extract on signal transducer and activator of transcription 3 (STAT3) expression and tongue epithelial cell death caused by oral candidiasis under immunosuppressive conditions.<\/jats:p><jats:p>\n          Materials and Methods\u2003To obtain the oral candidiasis model, 20 healthy male Rattus norvegicus (Wistar) rats were administered oral dexamethasone and tetracycline for 14 days and oral candidiasis was induced with Candida albicans (ATCC-10231) 1 McFarland. They were then randomized into four groups\u2014immunosuppression (K-), oral candidiasis (K\u2009+\u2009), nystatin treatment (P1), and 20% A. ilicifolius methanolic extract treatment (P2) and were treated for 14 days. Histological analyses of cell death and candida invasion and immunohistochemical analysis of STAT3 in epithelial cells were performed.<\/jats:p><jats:p>\n          Statistical Analysis\u2003Epithelial cell death data were analyzed using one-way analysis of variance (ANOVA) and the post hoc Games\u2013Howell test (p\u2009&lt;\u20090.05) and STAT3 expression with one-way ANOVA and the post hoc least significant difference test (p\u2009&lt;\u20090.05).<\/jats:p><jats:p>\n          Results\u2003Cell death was significantly different between K- and K+ and between K+ and P1 and P2 (p\u2009&lt;\u20090.05); there were no significant differences between K- and P1 and P2 and between P1 and P2 (p\u2009&gt;\u20090.05). STAT3 expression was significantly different between K- and P1 and P2 and between K+ and P1 and P2 (p\u2009&lt;\u20090.05), but there were no significant differences between K+ and K- and between P1 and P2 (p\u2009&gt;\u20090.05).<\/jats:p><jats:p>\n          Conclusion\u2003Topical administration of A. ilicifolius methanol extract increased STAT3 expression and decreased tongue epithelial cell death caused by oral candidiasis.<\/jats:p>","DOI":"10.1055\/s-0042-1760298","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T23:50:55Z","timestamp":1676073055000},"page":"1201-1206","source":"Crossref","is-referenced-by-count":3,"title":["Acanthus ilicifolius Methanolic Extract for Oral Candidiasis Treatment through Tongue Epithelial STAT3 and Cell Death Evaluation"],"prefix":"10.1055","volume":"17","author":[{"given":"Syamsulina","family":"Revianti","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, Universitas Hang Tuah, Surabaya, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5501-3499","authenticated-orcid":false,"given":"Dwi","family":"Andriani","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, Universitas Hang Tuah, Surabaya, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agni Febrina","family":"Pargaputri","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, Universitas Hang Tuah, Surabaya, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mardiyanto Riski","family":"Hartono","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, Universitas Hang Tuah, Surabaya, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1055\/s-0040-1709944","article-title":"Anti-inflammatory effect of Musa acuminata stem","volume":"14","author":"M L Apriasari","year":"2020","journal-title":"Eur J Dent"},{"issue":"06","key":"ref2","first-page":"2521","article-title":"Identification of compounds isolated from a methanolic extract of Acanthus ilicifolius leaves and evaluation of their antifungal and antioxidant activity","volume":"21","author":"D Andriani","year":"2020","journal-title":"Biodivers J Biol Divers"},{"issue":"S 01","key":"ref3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.21315\/aos2021.16.s1.4","article-title":"Acanthus ilicifolius L. treatment for oral candidiasis with immunosuppressive conditions subjected to p38 MAPK enhancement","volume":"16","author":"D 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of apoptosis in oral epithelial cells by Candida albicans","volume":"27","author":"C C Villar","year":"2012","journal-title":"Mol Oral Microbiol"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/21505594.2015.1012981","article-title":"Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface","volume":"6","author":"D L Moyes","year":"2015","journal-title":"Virulence"},{"issue":"02","key":"ref12","first-page":"1","article-title":"Derajat displasia epitel pada lidah yang diinduksi candida albicans dengan kondisi imunosupresi","volume":"13","author":"D Andriani","year":"2020","journal-title":"DENTA J Kedokteran Gigi"},{"issue":"04","key":"ref13","first-page":"205","article-title":"The effects of Acanthus ilicifolius chloroform extract on TLR-2 expression of macrophages in oral candidiasis","volume":"51","author":"D Andriani","year":"2018","journal-title":"Maj Kedokt Gigi"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"012056","DOI":"10.1088\/1755-1315\/217\/1\/012056","article-title":"Enhance of IL-22 expression in oral candidasis immunosuppressed model with Acanthus ilicifolius extract therapy","volume":"217","author":"D Andriani","year":"2019","journal-title":"IOP Conf Ser Earth Environ Sci"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"e13371","DOI":"10.1111\/cmi.13371","article-title":"Candidalysin triggers epithelial cellular stresses that induce necrotic death","volume":"23","author":"M Blagojevic","year":"2021","journal-title":"Cell Microbiol"},{"key":"ref16","first-page":"3267","article-title":"Biofilm and epithelial thickness in tongue of Wistar rats (Rattus novergicus) induced by Candida albicans with immunosuppression condition","volume":"21","author":"D Andriani","year":"2021","journal-title":"Biochem Cell Arch"},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1055\/s-0040-1712779","article-title":"Quantification and pathogenicity of Candida albicans in denture-wearing and nondenture-wearing elderly","volume":"14","author":"B M Bachtiar","year":"2020","journal-title":"Eur J Dent"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2147\/DDDT.S100795","article-title":"Efficacy of nystatin for the treatment of oral candidiasis: a systematic review and meta-analysis","volume":"10","author":"X Lyu","year":"2016","journal-title":"Drug Des Devel Ther"},{"issue":"06","key":"ref19","first-page":"362","article-title":"Preliminary qualitative phytochemical screening and in vitro hypoglycemic potential of Acanthus ilicifolius and Evolvulus emerginatus","volume":"6","author":"G A Gayathri","year":"2014","journal-title":"Int J Pharm Pharm Sci"},{"issue":"02","key":"ref20","first-page":"243","article-title":", Adam A. Traditional medicinal uses, chemical constituents, and biological activities of mangrove plant, Acanthus ilicifolius, a brief review, American-Eurasian","volume":"15","author":"A Saranya","year":"2015","journal-title":"J Agric Environment Sci"},{"issue":"04","key":"ref21","first-page":"1770","article-title":"The JAK2\/STAT3 signaling pathway is required for inflammation and cell death induced by cerulein in AR42J cells","volume":"23","author":"W D Chen","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["European Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1760298.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T23:46:39Z","timestamp":1703893599000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1760298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":21,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2023,12,29]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1760298","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1305-7456","1305-7464"],"issn-type":[{"value":"1305-7456","type":"print"},{"value":"1305-7464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,10]]}}}