{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:18:30Z","timestamp":1772137110823,"version":"3.50.1"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":53,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avicenna J Med"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2003Telemedicine is widely used in neonatal services in developed countries, though its outcomes in low- and middle-income countries are controversial. Lack of expertise and\/or facilities, however, has limited its use in developing countries and around areas of military conflicts. We aim to study the implementation and management of therapeutic hypothermia (TH) in infants with hypoxic-ischemic encephalopathy (HIE) with the help of telemedicine in a resource-limited country.<\/jats:p>\n                  <jats:p>Methodology\u2003This is a retrospective study, evaluating patients who received TH, guided by telemedicine, through a mobile app (Telegram), an application that allows sharing and archiving of information with other beneficial features. We assessed the feasibility of utilizing telemedicine in guiding the application of TH to infants affected with HIE in the North-West of Syria between July 2020 and July 2021. Feasibility was measured by parameters related to the time gaps between initiation of consultation and treatment and clinical short-term outcomes.<\/jats:p>\n                  <jats:p>Results\u2003Out of 5,545 newborn infants delivered during the study period, 22 patients were eligible for TH guided by telemedicine. Patients were referred for consultation at a median (interquartile range [IQR]) of 137 (35\u2013165) minutes of life. A median (IQR) of 12 (3\u201318) minutes elapsed between the call for a consultation and the consultant response and a median (IQR) of 30 (0\u201342) minutes elapsed between seeking the consultation and the initiation of cooling therapy. Eighteen patients completed cooling for 72\u2009hours. The patients' temperatures were within the target range (33\u201334\u00b0C) most of the time (84.1%).<\/jats:p>\n                  <jats:p>Conclusion\u2003Telemedicine is a feasible method to guide the implementation TH for HIE in resource-limited areas. The short-term success rate is relatively high; however, further studies with a larger population are needed to confirm these findings.<\/jats:p>","DOI":"10.1055\/s-0042-1760434","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T19:01:41Z","timestamp":1677178901000},"page":"035-042","source":"Crossref","is-referenced-by-count":2,"title":["The Feasibility of Telemedicine in the Implementation and Management of Therapeutic Hypothermia for Infants with Neonatal Hypoxic-Ischemic Encephalopathy in a Resource-Limited Country"],"prefix":"10.1055","volume":"13","author":[{"given":"Adnan","family":"Hadid","sequence":"additional","affiliation":[{"name":"Department of Pediatric, College of Medicine, King Saud University, Riyadh, Saudi Arabia"},{"name":"Neonatal Intensive Care Unit, King Saud University Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taher S.","family":"AL-Shantout","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Ohud Hospital, MOH, Madinah, Saudi Arabia"},{"name":"Neonatal Intensive Care Unit, Ohud Hospital, MOH, Madinah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9350-1004","authenticated-orcid":false,"given":"Rayan S.","family":"Terkawi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hamad General Hospital, Doha, Qatar"},{"name":"Department of Pediatrics, Sidra Medicine, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baraa M.","family":"Aldbes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Maternity and Children Hospital, Najran, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal M.","family":"Zahran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, EL-Ekhaa Hospital, Syrian Expatriate Medical Association, Idlib, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadia A.","family":"Alsatouf","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, EL-Ekhaa Hospital, Syrian Expatriate Medical Association, Idlib, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hani","family":"Najjar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Aladan Hospital, Hadiya, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MHD Hassan","family":"Mughrabieh","sequence":"additional","affiliation":[{"name":"Syrian Expatriate Medical Association (SEMA), Gaziantep, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour A.","family":"Alhadid","sequence":"additional","affiliation":[{"name":"College of medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Altirkawi","sequence":"additional","affiliation":[{"name":"Department of Pediatric, College of Medicine, King Saud University, Riyadh, Saudi Arabia"},{"name":"Neonatal Intensive Care Unit, King Saud University Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/pr.2013.206","article-title":"Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990","volume":"74","author":"A CC Lee","year":"2013","journal-title":"Pediatr Res"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1053\/j.semperi.2016.09.007","article-title":"Outcomes in childhood following therapeutic hypothermia for neonatal hypoxic-ischemic 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care service to neonates in medically underserved areas","volume":"24","author":"A Makkar","year":"2018","journal-title":"Telemed J E Health"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/s41372-020-00828-3","article-title":"Telemedicine consults to assess neonatal encephalopathy are feasible in the neonatal intensive care unit","volume":"41","author":"A K Craig","year":"2021","journal-title":"J Perinatol"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4103\/AJM.AJM_184_18","article-title":"Child and adolescent health in northwestern Syria: findings from Healthy-Syria 2017 study","volume":"9","author":"A S Terkawi","year":"2019","journal-title":"Avicenna J Med"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/ajm.AJM_190_18","article-title":"Women's health in Northwestern Syria: findings from healthy-Syria 2017 study","volume":"9","author":"A S 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