{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T08:08:55Z","timestamp":1768723735525,"version":"3.49.0"},"reference-count":103,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>OPA1 (Optic Atrophy 1) is a mitochondrial GTPase known to regulate fission of mitochondria. It was recently also shown to locate on lipid droplets in adipocytes where it functions as an A-kinase anchoring protein (AKAP) that mediates adrenergic control of lipolysis by facilitating PKA phosphorylation of perilipin (Plin1). In brown adipocytes indirect evidence support the notion that OPA1 regulation of fission serves to increase thermogenesis, which thereby contributes to dissipation of energy. In white adipocytes, OPA1 located on lipid droplets serves as a gatekeeper to control lipolysis induced by adrenergic agonists. However, the function of OPA1 in lipolysis and thermogenesis in inducible brown adipocytes (brite\/beige cells) remains elusive. Here we discuss the role of OPA1 in lipid metabolism.<\/jats:p>","DOI":"10.1055\/s-0043-100384","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T22:31:28Z","timestamp":1492727488000},"page":"276-285","source":"Crossref","is-referenced-by-count":22,"title":["OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes"],"prefix":"10.1055","volume":"49","author":[{"given":"Dinh-Toi","family":"Chu","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway"},{"name":"Institute for Research and Development, Duy Tan University, K7\/25 Quang Trung, Danang, Vietnam"},{"name":"Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam"},{"name":"College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Tao","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjetil","family":"Task\u00e9n","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway"},{"name":"K. G. Jebsen Inflammation Research Centre; University of Oslo, Oslo, Norway"},{"name":"Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1038\/emboj.2010.136","article-title":"Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis","volume":"29","author":"R Wilting","year":"2010","journal-title":"EMBO J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"B Cannon","year":"2004","journal-title":"Physiological Reviews"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ydbio.2006.04.449","article-title":"\u03b2-catenin activation is necessary and sufficient to 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