{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:50:52Z","timestamp":1788537052794,"version":"build-2803163510"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nIntroduction The cortisol\/ACTH ratio was supposed to be helpful in the screening of subclinical hypercortisolism (SHC) in the published literatures. This study assessed the cortisol\/ACTH ratio in patients with adrenal incidentaloma (AI) confirmed to have SHC and investigated its role for screening SCS in patients with AI.<\/jats:p><jats:p>\nMethods This descriptive retrospective study included 183 patients with AIs [45 with SHC and 138 with non-functional adenoma (NFA)]. Cortisol and ACTH levels were measured at 8:00, 16:00, and 0:00, and the cortisol\/ACTH ratio was calculated. ROC curve was used to evaluate efficacy of the cortisol\/ACTH ratio, explore the best cut-off value and its corresponding sensitivity and specificity.<\/jats:p><jats:p>\nResults The cortisol\/ACTH ratios at all time points were significantly higher in the SHC group than the NFA group (P&lt;0.05) and were significantly correlated with serum cortisol levels after the 1-mg dexamethasone suppression test (DST). Area Under the Curve (AUC) of the cortisol\/ACTH ratio at 0:00 and midnight serum cortisol levels were 0.893 (0.843\u20130.943) and 0.831 (0.765\u20130.806), respectively. A cortisol\/ACTH ratio at 0:00 cut-off of 32.18\u2009nM\/pM showed a sensitivity of 100% and specificity of 39.1%. The optimal cut-off was 68.83\u2009nM\/pM (sensitivity 86.7%, specificity 75.4%).<\/jats:p><jats:p>\nConclusions Patients with SHC have a higher cortisol\/ACTH ratio than those with NFAs. The cortisol\/ACTH ratio is significantly correlated with serum cortisol after the 1-mg DST. The diagnostic performance of the cortisol\/ACTH ratio at 0:00 is superior to midnight serum cortisol. Therefore, the cortisol\/ACTH ratio at 0:00 may be a reliable parameter for SHC screening in patient with AI.<\/jats:p>","DOI":"10.1055\/s-0043-101236","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T22:40:09Z","timestamp":1505947209000},"page":"71-76","source":"Crossref","is-referenced-by-count":4,"title":["The Role of Cortisol\/ACTH Ratio for Screening of Subclinical Hypercortisolism in Patients with Adrenal Incidentalomas"],"prefix":"10.1055","volume":"126","author":[{"given":"Lele","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chinese PLA General Hospital, Beijing, China"},{"name":"Chinese PLA Key Laboratory of Endocrinology and Metabolism, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chinese PLA General Hospital, Beijing, China"},{"name":"Chinese PLA Key Laboratory of Endocrinology and Metabolism, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtao","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chinese PLA General Hospital, Beijing, China"},{"name":"Chinese PLA Key Laboratory of Endocrinology and Metabolism, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chinese PLA General Hospital, Beijing, China"},{"name":"Chinese PLA Key Laboratory of Endocrinology and Metabolism, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chinese PLA General Hospital, Beijing, China"},{"name":"Chinese PLA Key Laboratory of Endocrinology and Metabolism, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chinese PLA General Hospital, Beijing, China"},{"name":"Chinese PLA Key Laboratory of Endocrinology and Metabolism, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chinese PLA General Hospital, Beijing, China"},{"name":"Chinese PLA Key Laboratory of Endocrinology and Metabolism, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,9,20]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-101236.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T23:30:58Z","timestamp":1519083058000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-101236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,20]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2018,2,19]]},"published-print":{"date-parts":[[2018,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-101236","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,20]]}}}