{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:52:58Z","timestamp":1778809978714,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002The success of any colonoscopy procedure depends upon the quality of bowel preparation. We evaluated the efficacy and safety of a new tailored dosing (TD) regimen compared with the approved PICOPREP day-before dosing regimen (DBD) in the European Union. <\/jats:p><jats:p>\n          Patient and methods\u2002Patients (\u2265\u200a18 years) undergoing colonoscopy were randomised (2:1) to TD (Dose 1, 10\u200a\u2013\u200a18 hours; Dose 2, 4\u200a\u2013\u200a6 hours before colonoscopy) or DBD (Dose 1 before 8:00AM on the day before colonoscopy; Dose 2, 6\u200a\u2013\u200a8 hours after Dose 1). The primary endpoint of overall colon cleansing efficacy was based on total Ottawa Scale (OS) scores (0\u200a\u2013\u200a14, excellent-worst). The key secondary endpoint was a binary endpoint based on the ascending colon OS (success 0 or 1, failure [\u2265\u200a2]). Convenience and satisfaction were evaluated similar to the primary and key secondary endpoints. Safety and tolerability were also evaluated. <\/jats:p><jats:p>\n          Results\u2002Use of the PICOPREP TD regimen resulted in a statistically significant reduction in the mean total Ottawa Scale score compared to the PICOPREP DBD regimen (\u20133.93, 95\u200a% confidence intervals [CI]:\u200a\u2013\u200a4.99,\u200a\u2013\u200a2.97; P\u200a&lt;\u200a0.0001) in the intent-to-treat analysis set. The PICOPREP TD regimen also resulted in a statistically significant increase in the odds of achieving an ascending colon OS score\u200a\u2264\u200a1, compared to the PICOPREP DBD regimen (estimated odds ratio 9.18, 95\u200a% CI: 4.36, 19.32; P\u200a&lt;\u200a0.0001). There was no statistically significant difference in the overall rate of treatment-emergent adverse events (12\u200a% (TD) and 5.7\u200a% (DBD), respectively, P\u200a=\u200a0.2988). The convenience and satisfaction were comparable in the two groups. <\/jats:p><jats:p>\n          Conclusion\u2002The TD regimen was superior to the DBD regimen for overall and ascending colon cleansing efficacy. <\/jats:p><jats:p>ClinicalTrials.gov Identifier: NCT02239692<\/jats:p>","DOI":"10.1055\/s-0043-102433","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T22:49:39Z","timestamp":1491259779000},"page":"E282-E290","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and safety of PICOPREP tailored dosing compared with PICOPREP day-before dosing for colon cleansing: a multi-centric randomised study"],"prefix":"10.1055","volume":"05","author":[{"given":"Ralf","family":"Kiesslich","sequence":"additional","affiliation":[{"name":"Klinikdirektor ZIM II, Sprecher ZIM (Zentrum f\u00fcr Innere Medizin), Helios Dr. Horst Schmidt Kliniken Wiesbaden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schubert","sequence":"additional","affiliation":[{"name":"Gastroenterologie am Bayerischen Platz, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mross","sequence":"additional","affiliation":[{"name":"Praxis Dr. med. Michael R Mross, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Klugmann","sequence":"additional","affiliation":[{"name":"Internistische Gemeinschaftspraxis, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Klemt-Kropp","sequence":"additional","affiliation":[{"name":"Medisch Centrum, Alkmaar, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imke","family":"Behnken","sequence":"additional","affiliation":[{"name":"Internistisches Facharztzentrum Dr M Scholz, Langen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillaume","family":"Bonnaud","sequence":"additional","affiliation":[{"name":"Clinique des C\u00e8dres, Blagnac, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Keulen","sequence":"additional","affiliation":[{"name":"Orbis Medisch Centrum, Sittard, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Groenen","sequence":"additional","affiliation":[{"name":"Rijnstate Arnhem, Wagnerlaan, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Blaker","sequence":"additional","affiliation":[{"name":"Gastroenterologie Eppendorfer Baum, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Ponchon","sequence":"additional","affiliation":[{"name":"Ed Herriot Hop\u00ectal, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfred","family":"Landry","sequence":"additional","affiliation":[{"name":"MVZ Dachau, Dachau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredin","family":"Stoltenberg","sequence":"additional","affiliation":[{"name":"Ferring Pharmaceuticals, Kay Fiskers Plads 11 Copenhagen S, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,4,3]]},"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-102433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T18:35:01Z","timestamp":1557167701000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-102433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2017,3,22]]},"published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-102433","relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}