{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:54:53Z","timestamp":1789502093893,"version":"build-2803163510"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nDecrease in mortality and morbidity is observed in thalassaemia major patients with reduced iron load in comparison to heavy iron loaded patients. Effective and complete treatment of transfusional iron overload can be achieved by chelation protocols that can eliminate excess iron and maintain normal iron stores (NIS).<\/jats:p><jats:p>\nThe maintenance of NIS, i. e., serum ferritin (350\u2009\u03bcg\/L &gt;), MRI T2* cardiac (&gt;20\u2009ms) and liver (&gt;6.3\u2009ms) relaxation time levels was monitored in 16 thalassaemia major patients (32\u201353 years, 12 splenectomized, 10 male, erythrocyte transfusions 120\u2013323\u2009ml\/kg\/year) for about 90 patient years. The patients were treated with individualised tailor-made deferiprone or deferiprone\/deferoxamine combination protocols.<\/jats:p><jats:p>\nIn 8 patients deferiprone (50\u2013100\u2009mg\/kg\/day) was sufficient for maintaining NIS and withdrawal of deferiprone for 28 months in total was necessary in 4 patients for preventing iron deficiency. In 3 other patients intermittent deferoxamine (50\u201375\u2009mg\/kg\/8\u201330\u2009h, 1\u20134 days\/week) in combination with deferiprone (75\u2013100\u2009mg\/kg\/day) was sufficient for maintaining NIS. In the remaining 5 patients deferiprone (75\u2013100\u2009mg\/kg\/day) and deferoxamine (50\u201360\u2009mg\/kg\/8\u201315\u2009h, 1\u20137 days\/week) combination was used for maintaining NIS, as a result of increased transfusions which were caused mainly by splenomegaly and infections. No toxic side effects were detected during the study. Lower chelation doses were used for the maintenance of NIS in comparison to iron loaded categories of patients.<\/jats:p><jats:p>\nThe safe maintenance of NIS using deferiprone and deferiprone\/deferoxamine combinations should be considered as an optimum therapy for the complete treatment of iron overload in the majority of thalassaemia patients.<\/jats:p>","DOI":"10.1055\/s-0043-102691","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T23:46:24Z","timestamp":1490053584000},"page":"404-411","source":"Crossref","is-referenced-by-count":22,"title":["Prevention of Iron Overload and Long Term Maintenance of Normal Iron Stores in Thalassaemia Major Patients using Deferiprone or Deferiprone Deferoxamine Combination"],"prefix":"10.1055","volume":"67","author":[{"given":"Annita","family":"Kolnagou","sequence":"additional","affiliation":[{"name":"Postgraduate Research Institute of Science, Technology, Environment and Medicine Limassol, Cyprus"},{"name":"Thalassaemia Unit, Paphos General Hospital, Paphos, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kontoghiorghe","sequence":"additional","affiliation":[{"name":"Postgraduate Research Institute of Science, Technology, Environment and Medicine Limassol, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kontoghiorghes","sequence":"additional","affiliation":[{"name":"Postgraduate Research Institute of Science, Technology, Environment and Medicine Limassol, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,3,20]]},"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-102691.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T08:01:27Z","timestamp":1513670487000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-102691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,20]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2017,7,6]]},"published-print":{"date-parts":[[2017,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-102691","relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,20]]}}}