{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T23:45:23Z","timestamp":1771976723596,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background Postnatal catch-up growth and rapid weight gain after intrauterine growth restriction (IUGR) seem to increase the risk for later disease. This study aimed to compare features of the metabolic syndrome early in life between IUGR and appropriate for gestational age (AGA) infants.<\/jats:p><jats:p>\nPatients Data for 9 infants with IUGR defined by a birth weight&lt;10th percentile and ultrasound-proven placental insufficiency and 11 AGA children were available.<\/jats:p><jats:p>\nMethod Postnatal growth, auxological, cardiovascular, and metabolic parameters up to a chronological age of 6 years were assessed: Fasting serum concentrations of LDL-cholesterol, insulin, leptin, IGF-I, DHEAS, skinfold thicknesses, blood pressure, and mean carotid intima-media thickness (cIMT).<\/jats:p><jats:p>\nResults All IUGR infants showed catch-up growth, although mean BMI SDS and total subcutaneous fat mass at the age of 6 years were still slightly lower compared to the AGA cohort. Reduced serum leptin concentrations were observed in IUGR infants (p=0.02), whereas no significant difference was found for IGF-I, insulin, LDL-cholesterol and DHEAS concentrations. Mean cIMT was significantly higher in IUGR infants (p&lt;0.05). Mean arterial pressure did no differ.<\/jats:p><jats:p>\nDiscussion and Conclusion In 6-year-old IUGR infants with catch-up growth, who still had a slightly reduced BMI SDS compared to the AGA group, signs of subclinical atherosclerosis were detectable suggesting that cardiovascular risk in IUGR may be present even in the absence of excessive growth.<\/jats:p>","DOI":"10.1055\/s-0043-104528","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T04:47:21Z","timestamp":1500353241000},"page":"209-215","source":"Crossref","is-referenced-by-count":6,"title":["Intrauterine Growth Restriction (IUGR) Induces Signs of Subclinical Atherosclerosis in 6-Year-Old Infants Despite Absence Of Excessive Growth"],"prefix":"10.1055","volume":"229","author":[{"given":"Anja","family":"Tzschoppe","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, University of Erlangen-Nuremberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"von Kries","sequence":"additional","affiliation":[{"name":"Institute of Social Paediatrics and Adolescent Medicine, University of Munich, M\u00fcnchen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Struwe","sequence":"additional","affiliation":[{"name":"Regional Centre for Social Paediatrics, Klinikum Konstanz, Konstanz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Rascher","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, University of Erlangen-Nuremberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmuth-Guenther","family":"D\u00f6rr","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, University of Erlangen-Nuremberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"J\u00fcngert","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, University of Erlangen-Nuremberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Rauh","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, University of Erlangen-Nuremberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Erlangen-Nuremberg, Erlangen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Schild","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, DIAKOVERE gGmbH, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamme","family":"Goecke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Aachen, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"D\u00f6tsch","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine University of Cologne, K\u00f6ln, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,7,17]]},"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-104528.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T08:20:58Z","timestamp":1513671658000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-104528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2017,7,17]]},"published-print":{"date-parts":[[2017,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-104528","relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}