{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:49:41Z","timestamp":1785912581158,"version":"3.56.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002The variables associated with gastroesophageal reflux (GER) after peroral endoscopic myotomy (POEM) are largely unknown. This study aimed to: 1) identify the prevalence of reflux esophagitis and asymptomatic GER in patients who underwent POEM, and 2) evaluate patient and intraprocedural variables associated with post-POEM GER.<\/jats:p><jats:p>\n          Patients and methods\u2002All patients who underwent POEM and subsequent objective testing for GER (pH study with or without upper gastrointestinal [GI] endoscopy) at seven tertiary academic centers (one Asian, two US, four European) were included. Patients were divided into two groups: 1) DeMeester score \u2265\u200a14.72 (cases) and 2) DeMeester score of &lt;\u200a14.72 (controls). Asymptomatic GER was defined as a patient with a DeMeester score \u2265\u200a14.72 who was not consuming proton pump inhibitor (PPI).<\/jats:p><jats:p>\n          Results\u2002A total of 282 patients (female 48.2\u200a%, Caucasian 84.8\u200a%; mean body mass index 24.1\u200akg\/m2) were included. Clinical success was achieved in 94.3\u200a% of patients. GER evaluation was completed after a median follow-up of 12 months (interquartile range 10\u200a\u2013\u200a24 months). A DeMeester score of\u200a\u2265\u200a14.72 was seen in 57.8\u200a% of patients. Multivariable analysis revealed female sex to be the only independent association (odds ratio 1.69, 95\u200a% confidence interval 1.04\u200a\u2013\u200a2.74) with post-POEM GER. No intraprocedural variables were associated with GER. Upper GI endoscopy was available in 233 patients, 54 (23.2\u200a%) of whom were noted to have reflux esophagitis (majority Los Angeles Grade A or B). GER was asymptomatic in 60.1\u200a%.<\/jats:p><jats:p>\n          Conclusion\u2002Post-POEM GER was seen in the majority of patients. No intraprocedural variables were identified to allow for potential alteration in procedural technique. <\/jats:p>","DOI":"10.1055\/s-0043-105485","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T22:50:26Z","timestamp":1493938226000},"page":"634-642","source":"Crossref","is-referenced-by-count":156,"title":["Gastroesophageal reflux after peroral endoscopic myotomy: a multicenter case\u2013control study"],"prefix":"10.1055","volume":"49","author":[{"given":"Vivek","family":"Kumbhari","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Familiari","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Catholic University, Gemelli University Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Bjerregaard","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Pioche","sequence":"additional","affiliation":[{"name":"Gastroenterologie, Pavillon H H\u00f4pital Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of General and Gastrointestinal Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weon","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHA Bundang Medical Center, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bu","family":"Hayee","sequence":"additional","affiliation":[{"name":"Gastroenterology, King\u2019s College Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cali","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Catholic University, Gemelli University Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saowanee","family":"Ngamruengphong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Mion","sequence":"additional","affiliation":[{"name":"Gastroenterologie, University of Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Hernaez","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas, United States"},{"name":"Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Roman","sequence":"additional","affiliation":[{"name":"Gastroenterologie, Pavillon H H\u00f4pital Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Tieu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"El Zein","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokunbo","family":"Ajayi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amyn","family":"Haji","sequence":"additional","affiliation":[{"name":"Gastroenterology, King\u2019s College Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHA Bundang Medical Center, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Hazey","sequence":"additional","affiliation":[{"name":"Division of General and Gastrointestinal Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Perry","sequence":"additional","affiliation":[{"name":"Division of General and Gastrointestinal Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Ponchon","sequence":"additional","affiliation":[{"name":"Gastroenterologie, Pavillon H H\u00f4pital Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rastislav","family":"Kunda","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Costamagna","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Catholic University, Gemelli University Hospital, Rome, Italy"},{"name":"IHU-USIAS, University of Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouen","family":"Khashab","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,5,4]]},"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-105485.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T07:35:39Z","timestamp":1513668939000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-105485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,4]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2017,6,28]]},"published-print":{"date-parts":[[2017,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-105485","relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,4]]}}}