{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:59:32Z","timestamp":1769518772794,"version":"3.49.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Per-oral endoscopic myotomy (POEM) has emerged as an efficacious treatment modality for the management of achalasia cardia (AC) and non-achalasia spastic esophageal motility disorders. Initial results are encouraging. We analyzed the safety and efficacy of POEM in a large cohort of patients with AC.<\/jats:p><jats:p>\n          Patients and methods\u2002The data from patients who underwent POEM (from January 2013 to June 2016) was prospectively collected and analyzed. Clinical success was defined as Eckardt score \u2264\u200a3 after POEM procedure. Objective parameters including high-resolution manometry (HRM) and timed barium swallow (TBS) were analyzed and compared before and after the procedure. Gastroesophageal reflux was analyzed using 24-hour pH impedance study and esophagogastro-duodenoscopy. <\/jats:p><jats:p>\n          Results\u2002A total of 408 patients (mean age 40 years, range 4\u200a\u2013\u200a77 years) underwent POEM during the specified period. POEM could be successfully completed in 396 (97\u200a%) patients. Clinical success rates at 1, 2 and 3 years were 94\u200a%, 91\u200a% and 90\u200a%, respectively. Mean Eckardt score was 7.07\u200a\u00b1\u200a1.6 prior to POEM and 1.27\u200a\u00b1\u200a1.06 after POEM (P\u200a=\u200a0.001) at 1 year. Significant improvement in esophageal emptying on TBE (&gt;\u200a50\u200a%) was documented in 93.8\u200a% patients who completed 1-year follow up. Pre-procedure and post-procedure mean lower esophageal sphincter pressure was 45\u200a\u00b1\u200a16.5\u200ammHg and 15.6\u200a\u00b1\u200a6.1\u200ammHg, respectively (P\u200a=\u200a0.001). Technical and clinical success were comparable in na\u00efve vs prior treated cases (97.3\u200a% vs 96.8\u200a%, P\u200a=\u200a0.795) (95.7\u200a% vs 92.6\u200a%, P\u200a=\u200a0.275). GERD was documented in 28.3\u200a% patients with 24-hour pH-impedance study and erosive esophagitis was seen in 18.5\u200a% of patients who underwent POEM. <\/jats:p><jats:p>\n          Conclusions\u2002POEM is safe, effective and has a durable response in patients with achalasia cardia. Prior treatment does not influence the outcomes of POEM. <\/jats:p>","DOI":"10.1055\/s-0043-105517","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T22:44:57Z","timestamp":1494024297000},"page":"E331-E339","source":"Crossref","is-referenced-by-count":74,"title":["Per-oral endoscopic myotomy for achalasia cardia: outcomes in over 400 consecutive patients"],"prefix":"10.1055","volume":"05","author":[{"given":"Zaheer","family":"Nabi","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology \u2013 Gastroenterology, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Ramchandani","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology \u2013 Gastroenterology, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika","family":"Chavan","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology \u2013 Gastroenterology, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Kalapala","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology \u2013 Gastroenterology, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh","family":"Darisetty","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology \u2013 Anaestheisa, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guduru","family":"Rao","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology \u2013 Surgical Gastroenterology, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nageshwar","family":"Reddy","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology \u2013 Gastroenterology, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,5,5]]},"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-105517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T18:48:09Z","timestamp":1557168489000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-105517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2017,5,5]]},"published-print":{"date-parts":[[2017,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-105517","relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}