{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:43:21Z","timestamp":1780717401474,"version":"3.54.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr R\u00f6ntgenstr"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n            Purpose\u2002We explored the diagnostic value of diffusion-weighted MRI (DWI) for tumor characterization, differentiation and therapy monitoring in pediatric patients with extracranial neuroblastic tumors.<\/jats:p><jats:p>\n            Materials and Methods\u2002All 29 patients (14 girls, median age: 3 years) with neuroblastoma (NB, n\u200a=\u200a19), ganglioneuroblastoma (GNB, n\u200a=\u200a4) and ganglioneuroma (GN, n\u200a=\u200a6) who\u00a0had had at least one in-house DWI examination since\u00a02005\u00a0were identified and retrospectively analyzed. Two\u00a0independent blinded readers measured ADC values (unit: 10\u22123\u200amm2\/s) and signal intensity ratios (SIRs) of the primary tumor and, if applicable, of the tumor after chemotherapy, metastases and tumor relapse.<\/jats:p><jats:p>\n            Results\u2002The pre-treatment ADC was 0.90\u200a\u00b1\u200a0.23 in NB\/GNB and 1.70\u200a\u00b1\u200a0.36 in GN without overlap between the two\u00a0entities for both readers, 0.67\u200a\u00b1\u200a0.14 in metastases and 0.72\u200a\u00b1\u200a0.18 in tumor relapse. With chemotherapy, mean ADC increased to 1.54\u200a\u00b1\u200a0.33 in NB\/GNB and to 1.23\u200a\u00b1\u200a0.27 in metastases (p\u200a&lt;\u200a0.05). The median SIRs of various tumor lesions vs. liver, vs. muscle tissue and vs. adjacent tissue were significantly higher on DWI (range: 2.4\u200a\u2013\u200a9.9) than on ce-T1w (range: 1.0\u200a\u2013\u200a1.8, all p\u200a&lt;\u200a0.05). The coefficient of variation (CV) was \u2264\u200a8.0\u200a% for ADC and \u2264\u200a16.4\u200a% for signal intensity data.<\/jats:p><jats:p>\n            Conclusion\u2002Based on mean ADC, DWI distinguishes between NB\/GNB and GN with high certainty and provides plausible quantitative data on tumor response to therapy. Lesion conspicuity, as measured by SIR, is superior on DWI, compared to ce-T1w. DWI as a noninvasive, radiation-free and widely available imaging technique should be an integral part of MR imaging for neuroblastic tumors and should undergo prospective evaluation in multicenter studies.<\/jats:p><jats:p>\n            Key Points\u2002<\/jats:p><jats:p>\n            Citation Format\n          <\/jats:p>","DOI":"10.1055\/s-0043-108993","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T18:54:46Z","timestamp":1494960886000},"page":"640-650","source":"Crossref","is-referenced-by-count":31,"title":["Diagnostic Value of Diffusion-Weighted MRI for Tumor Characterization, Differentiation and Monitoring in Pediatric Patients with Neuroblastic Tumors"],"prefix":"10.1055","volume":"189","author":[{"given":"Henning","family":"Neubauer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Germany"},{"name":"Department of Diagnostic and Interventional Radiology, University Hospital of W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Hospital of\u00a0W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital of W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pabst","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital of W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinrad","family":"Beer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,5,16]]},"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-108993.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T02:32:56Z","timestamp":1513650776000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-108993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,16]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2017,6,26]]},"published-print":{"date-parts":[[2017,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-108993","relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"value":"1438-9029","type":"print"},{"value":"1438-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,16]]}}}