{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:26:27Z","timestamp":1790436387588,"version":"4.1.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and aims\u2002Chemoradiotherapy for head and neck cancer (HNC) with\/without laryngectomy commonly causes dysphagia. Pharyngoesophageal junction (PEJ) stricturing is an important contributor. We aimed to validate a functional lumen imaging probe (the EndoFLIP system) as a tool for quantitating pretreatment PEJ distensibility and treatment-related changes in HNC survivors with dysphagia and to evaluate the diagnostic accuracy of EndoFLIP-derived distensibility in detecting PEJ strictures. <\/jats:p><jats:p>\n          Methods\u2002We studied 34 consecutive HNC survivors with long-term (&gt;\u200a12 months) dysphagia who underwent endoscopic dilation for suspected strictures. Twenty non-dysphagic patients undergoing routine endoscopy served as controls. PEJ distensibility was measured at endoscopy with the EndoFLIP system pre- and post-dilation. PEJ stricture was defined as the presence of a mucosal tear post-dilation. <\/jats:p><jats:p>\n          Results\u2002PEJ stricture was confirmed in 22\/34 HNC patients (65\u200a%). During distension up to 60\u200ammHg, the mean EndoFLIP-derived narrowest cross-sectional area (nCSA) in HNC patients with strictures, without strictures, and in controls were 58\u200amm2 (95\u200a% confidence interval [CI] 22 to 118), 195\u200amm2 (95\u200a%CI 129 to 334), and 227\u200amm2 (95\u200a%CI 168 to 316), respectively. A cutoff of 114\u200amm2 for the nCSA at the PEJ had perfect diagnostic accuracy in detecting strictures (area under the receiver operating characteristic curve\u200a=\u200a1). In patients with strictures, a single session of dilation increased the nCSA by 29\u200amm2 (95\u200a%CI 20 to 37; P\u200a&lt;\u200a0.001). In patients with no strictures, dilation caused no change in the nCSA (mean difference 13\u200amm2 [95\u200a%CI \u22124 to 30]; P\u200a=\u200a0.13). <\/jats:p><jats:p>\n          Conclusions\u2002EndoFLIP is a highly accurate technique for the detection of PEJ strictures. EndoFLIP may complement conventional diagnostic tools in the detection of pharyngeal outflow obstruction.<\/jats:p>","DOI":"10.1055\/s-0043-110670","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T22:53:19Z","timestamp":1496271199000},"page":"848-854","source":"Crossref","is-referenced-by-count":20,"title":["Clinical utility of a functional lumen imaging probe in management of dysphagia following head and neck cancer therapies"],"prefix":"10.1055","volume":"49","author":[{"given":"Peter","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St George Hospital, Sydney, New South Wales, Australia"},{"name":"St George Clinical School, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Szczesniak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St George Hospital, Sydney, New South Wales, Australia"},{"name":"St George Clinical School, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Maclean","sequence":"additional","affiliation":[{"name":"Speech Pathology Department, St George Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St George Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Quon","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Hospital, Baltimore, Maryland, USA"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Cancer Care Centre, St George Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St George Hospital, Sydney, New South Wales, Australia"},{"name":"St George Clinical School, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St George Hospital, Sydney, New South Wales, Australia"},{"name":"St George Clinical School, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,5,31]]},"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-110670.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T10:28:10Z","timestamp":1513679290000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-110670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,31]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2017,8,29]]},"published-print":{"date-parts":[[2017,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-110670","relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,31]]}}}