{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:48:01Z","timestamp":1762102081053},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngo-Rhino-Otol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die BEMED-Studie (BMJ 2016; 352: DOI 10.1136) war eine multizentrische, mehrarmige, placebokontrollierte Doppelblindstudie, die Patienten\n                    (zwischen 18 \u2013 80\u00a0Jahren) mit einem ein- oder bds. M. Meni\u00e8re einschlie\u00dfen sollte, bei der eine Niedrig- (2\u00a0\u00d7\u00a024\u2005mg\/d)- vs. Hochdosis\n                    (3\u00a0\u00d7\u00a048\u2005mg\/d) Betahistintherapie vs. Placebo verglichen wurden. Der prim\u00e4re Endpunkt sollte die \u201eper Tagebuch dokumentierte Rate von\n                    Schwindelattacken, die l\u00e4nger als 20\u2005min dauerten\u201c sein. Der Hauptbefund der Studie war, da\u00df Betahistin im Vergleich zu Placebo beim M.\n                    Meni\u00e9re nicht wesentlich besser in der Reduktion der Anfallsh\u00e4ufigkeit abschnitt. Dies soll in der vorliegenden Arbeit kritisch diskutiert\n                    werden.<\/jats:p>","DOI":"10.1055\/s-0043-113690","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T18:30:57Z","timestamp":1504031457000},"page":"519-521","source":"Crossref","is-referenced-by-count":8,"title":["Die Behandlung des M. Meni\u00e8re mit Betahistin: Kritische Anmerkungen zur BEMED-Studie"],"prefix":"10.1055","volume":"21","author":[{"given":"A.","family":"Ernst","sequence":"additional","affiliation":[{"name":"HNO-Klinik im ukb"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Schlattmann","sequence":"additional","affiliation":[{"name":"HNO-Klinik im ukb"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Waldfahrer","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohren-Klinik, Kopf- und Halschirurgie, Universit\u00e4tsklinikum Erlangen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Westhofen","sequence":"additional","affiliation":[{"name":"HNO-Univ.klinik der RWTH Aachen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,8,29]]},"container-title":["Laryngo-Rhino-Otologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-113690.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T05:27:19Z","timestamp":1513661239000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-113690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2017,8,29]]},"published-print":{"date-parts":[[2017,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-113690","relation":{},"ISSN":["0935-8943","1438-8685"],"issn-type":[{"value":"0935-8943","type":"print"},{"value":"1438-8685","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}