{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:46:54Z","timestamp":1762249614188},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ethanol leaf extract of Andrographis paniculata was used to ameliorate the renal toxicity induced by cisplatin in 28 rats divided into four groups of seven rats per group. Group A received normal saline for the duration of the experiment. Group B animals were treated with cisplatin (10\u2009mg\/kg i.p) on day 1 and 3 days after received normal saline for the next 7 days while groups C and D animals also received 10\u2009mg\/kg dose of cisplatin on day 1 but after 3 days were then respectively treated with 200 and 400\u2009mg\/kg doses of the extract of Andrographis paniculata for the remaining 7 days through oral administration. Serum chemistry was used for the determination of markers of oxidative stress, anti-oxidant enzymes, serum biomarkers etc. Histopathology and immunohistochemistry were also carried out. Results showed that all oxidative stress markers assayed were significantly increased in group B animals but reverse is the case for groups C and D. On the other hand, antioxidant enzymes assayed experienced significant increase for groups C and D while these parameters experienced significant decrease for group B animals. Histopathology showed severe infiltration of inflammatory cells into renal tissues of group B animals whereas for groups C and D animals, only moderate glomerular degeneration was noted. In immunohistochemistry, while there is higher expression of KIM-1 for group B, there was a lower expression in groups C and D. Again, there was lower expression of Nrf2 for group B but higher expressions in groups C and D animals.<\/jats:p>","DOI":"10.1055\/s-0043-118179","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T22:45:02Z","timestamp":1505256302000},"page":"23-32","source":"Crossref","is-referenced-by-count":12,"title":["The Protective Effect of the Ethanol Leaf Extract of Andrographis Paniculata on Cisplatin-Induced Acute Kidney Injury in Rats Through nrf2\/KIM-1 Signalling Pathway"],"prefix":"10.1055","volume":"68","author":[{"given":"Bisi","family":"Adeoye","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Ibadan, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebunoluwa","family":"Asenuga","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology, University of Benin, Benin City, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ademola","family":"Oyagbemi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Ibadan, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Temidayo","family":"Omobowale","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeolu","family":"Adedapo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Ibadan, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,9,12]]},"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-118179.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T06:36:18Z","timestamp":1513924578000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-118179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,12]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2017,12,21]]},"published-print":{"date-parts":[[2018,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-118179","relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,12]]}}}