{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:40:19Z","timestamp":1774287619001,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Resistance to the action of growth hormone (GH) frequently complicates liver cirrhosis, while, physiologically, the activation of GH receptor (GHR) determines phosphorylation of signal transducer and activator of transcription (STAT)-5 and the consequent induction of insulin-like growth factor-1 (IGF-1) expression. The suppressor of cytokine signaling (SOCS)-3 negatively regulates this intracellular cascade. We aimed to evaluate the hepatic expression of the GH\/IGF-1 axis components in the liver of patients with HCV-related chronic hepatitis at different fibrosis stages. The expression of GH\/IGF-1 axis components, such as GHR, IGF-1, STAT5-p, and SOCS-3, was assessed by immunohistochemistry at the lobular level in 61 patients with HCV-related hepatitis. At the hepatocyte level, IGF-1 and nuclear STAT5-p positivity scores showed negative correlations with fibrosis stage, while SOCS-3 score a positive one (p&lt;0.05 for all). Furthermore, the reduction of hepatocyte score of IGF-1 expression was associated with the serological parameters of liver damage (p&lt;0.05) and with the increase of the score of IGF-1 expression by hepatic stellate cells (p&lt;0.05). IGF-1 expression by hepatocytes was reduced with fibrosis progression, probably due to the impairment of GHR intracellular cascade by the SOCS-3 activation already in pre-cirrhotic stages. The inverse correlation between IGF-1 expressed by hepatocytes and by hepatic stellate cells suggests that IGF-1 may exert specific functions in different hepatic cells.<\/jats:p>","DOI":"10.1055\/s-0043-118911","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T18:57:51Z","timestamp":1505761071000},"page":"145-151","source":"Crossref","is-referenced-by-count":14,"title":["Impairment of GH\/IGF-1 Axis in the Liver of Patients with HCV-Related Chronic Hepatitis"],"prefix":"10.1055","volume":"50","author":[{"given":"Simone","family":"Carotti","sequence":"additional","affiliation":[{"name":"Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Guarino","sequence":"additional","affiliation":[{"name":"Unit of Digestive Disease, University Campus Bio-Medico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Valentini","sequence":"additional","affiliation":[{"name":"Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio","family":"Porzio","sequence":"additional","affiliation":[{"name":"Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Vespasiani-Gentilucci","sequence":"additional","affiliation":[{"name":"Clinical Medicine and Hepatology Unit, University Campus Bio-Medico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Perrone","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, University Campus Bio-Medico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Zingariello","sequence":"additional","affiliation":[{"name":"Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Gallo","sequence":"additional","affiliation":[{"name":"Clinical Medicine and Hepatology Unit, University Campus Bio-Medico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Cicala","sequence":"additional","affiliation":[{"name":"Unit of Digestive Disease, University Campus Bio-Medico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Picardi","sequence":"additional","affiliation":[{"name":"Clinical Medicine and Hepatology Unit, University Campus Bio-Medico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Morini","sequence":"additional","affiliation":[{"name":"Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,9,18]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-118911.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T18:35:40Z","timestamp":1517855740000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-118911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,18]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2018,2,5]]},"published-print":{"date-parts":[[2018,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-118911","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,18]]}}}