{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:55:27Z","timestamp":1789545327720,"version":"build-2803163510"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"12","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Biopsies of non-specific mucosal findings are often performed during esophagogastroduodenoscopy (EGD). We sought to determine the prevalence and clinical utility of non-targeted biopsies of the stomach and esophagus.<\/jats:p><jats:p>\n          Patients and methods\u2002We conducted a retrospective review of 949 outpatient EGDs performed at a US tertiary referral center. Non-targeted biopsies of the stomach were defined as either \u201cnormal\u201d or \u201cmild\u201d to \u201cmoderate\u201d \u201cerythema\u201d or \u201cinflammation\u201d without other endoscopic features. Non-targeted biopsies of the esophagus and gastroesophageal junction (GEJ) were defined as endoscopically \u201cnormal\u201d mucosa. The primary outcome was the proportion of non-targeted biopsies resulting in \u201cdefinite management change.\u201d Secondary outcomes included histopathologic diagnoses of Helicobacter pylori, intestinal metaplasia and esophageal eosinophilia.<\/jats:p><jats:p>\n          Results\u2002Of 949 EGDs, 332 (35.0\u200a%, 95\u200a% CI 31.9\u200a\u2013\u200a38.1\u200a%) had a non-targeted biopsy taken at any site. Erythema in the gastric body and antrum was biopsied at a rate of 83\u200a\u2013\u200a86\u200a%, while biopsies of \u201cnormal\u201d-appearing mucosa occurred at rates from 3\u200a% (GEJ) to 15\u200a% (body and antrum). The percentage of non-targeted biopsies that led to definite management change ranged from 5\u200a% in the GEJ and esophagus to 9\u200a% in the antrum, but did not significantly differ by mucosal appearance. Multivariable regression analyses suggested associations of language and age &gt;\u200a50 with management change from non-targeted gastric biopsy.<\/jats:p><jats:p>\n          Conclusions\u2002Non-targeted biopsies of the stomach and esophagus led to definite management change in a small proportion of patients. Further studies are needed to identify patient and\/or endoscopic characteristics and techniques to improve the yield of this practice.<\/jats:p>","DOI":"10.1055\/s-0043-119791","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T19:15:46Z","timestamp":1512587746000},"page":"E1268-E1277","source":"Crossref","is-referenced-by-count":7,"title":["Low yield for non-targeted biopsies of the stomach and esophagus during elective esophagogastroduodenoscopy"],"prefix":"10.1055","volume":"05","author":[{"given":"Michael","family":"Dougherty","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Santoiemma","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California Los Angeles, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Metz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,12,6]]},"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-119791.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T15:37:09Z","timestamp":1557157029000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-119791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,11,21]]},"published-print":{"date-parts":[[2017,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-119791","relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]}}}