{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T20:04:11Z","timestamp":1751400251132},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nBackground and objective Soccer is associated with repetitive head trauma, which, as it is known from sports like football and boxing, can result in hypopituitarism. Gonadotropins and GH are the most common pituitary hormones to become deficient. GH deficiency is associated with an increased risk of cardiovascular mortality and has negative influence on body mass index, visceral fat mass, insulin resistance and sensitivity, bone mineral density and inflammatory markers. Therefore the aim of this study was to evaluate the somatotrope pituitary function in professional soccer players.<\/jats:p><jats:p>\nResearch design and methods  This clinical study included 15 male, professional soccer players with at least 10 years of professional training. Basal hormonal parameters of the pituitary axis were obtained from the participants. To assess GH-IGF-I axis, glucagon stimulation tests were used. Rise in growth hormone during glucagon test was analyzed and the prevalence of newly diagnosed hormone deficiencies was evaluated.<\/jats:p><jats:p>\nResults  Mean age of all participants was 31\u00b110 years. None of the 15 soccer players had GH deficiency. Mean rising factor of GH after stimulation with glucagon was 100 in all participants. We did not find signs of ACTH, TSH or LH\/FSH deficiency in any player.<\/jats:p><jats:p>\nConclusions  In this small collective of soccer players we did not find playing soccer to be a risk factor for the development of GH-deficiency. According to our data screening for somatotrope deficiency is not necessary. Further investigations in larger cohorts are needed.<\/jats:p>","DOI":"10.1055\/s-0043-119876","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T13:46:31Z","timestamp":1511358391000},"page":"306-308","source":"Crossref","is-referenced-by-count":6,"title":["Somatotrope Pituitary Function in Professional Soccer Players"],"prefix":"10.1055","volume":"126","author":[{"given":"Pia","family":"Roser","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Wehrhahn","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Krogmann","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Riedel","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justus","family":"Gille","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopedic Surgery, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, Luebeck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Flitsch","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistra\u00dfe 52, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Aberle","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,11,17]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-119876.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T22:40:43Z","timestamp":1527201643000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-119876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,17]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2018,5,24]]},"published-print":{"date-parts":[[2018,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-119876","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,17]]}}}