{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:58:53Z","timestamp":1790675933764,"version":"4.1.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Endoscopic techniques have demonstrated their effectiveness in metabolic surgery, notably through a gastrointestinal (GI) liner, with a less invasive approach than conventional surgery. Our study evaluates the safety and efficacy of endoscopic GI anastomosis (EGIA) using a lumen-apposing stent to secure the anastomosis. <\/jats:p><jats:p>\n          Materials and methods\u2002EGIA was performed using the transgastric approach with a two-channel endoscope with a novel stent (Cousin Biotech). First, a safety study with a follow-up of 12 months was performed on five piglets. Then, metabolic changes were investigated in a minipig model (n\u200a=\u200a10) before and after EGIA or open GIA (OGIA). <\/jats:p><jats:p>\n          Results\u2002EGIA was technically successful with no complications observed during clinical monitoring. Endoscopic and postmortem examinations during the second part of study showed a secure anastomosis between the stomach and the intestinal limb in all except one minipig. Both minipigs subjected to EGIA and those in the control group (OGIA) exhibited increased postprandial glucagon-like peptide-1 (GLP-1) production (incretin secretion) and impaired D-xylose absorption (malabsorption effect). <\/jats:p><jats:p>\n          Conclusion\u2002Performing EGIA with this dedicated stent appears safe, technically feasible, durable, and reproducible in providing a simple and effective endoscopic GI bypass capable of ensuring metabolic effect.<\/jats:p>","DOI":"10.1055\/s-0043-120439","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T18:47:21Z","timestamp":1512154041000},"source":"Crossref","is-referenced-by-count":2,"title":["Increased postprandial glucagon-like peptide-1 (GLP-1) production after endoscopic gastrointestinal bypass using the Cousin lumen-apposing stent in a porcine model"],"prefix":"10.1055","author":[{"given":"Robert","family":"Caiazzo","sequence":"additional","affiliation":[{"name":"University of Lille, Lille; INSERM 1190, European Genomics Institute for Diabetes (EGID), Lille, France"},{"name":"Centre Hospitalier R\u00e9gional Universitaire, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Branche","sequence":"additional","affiliation":[{"name":"University of Lille, Lille; INSERM 1190, European Genomics Institute for Diabetes (EGID), Lille, France"},{"name":"Centre Hospitalier R\u00e9gional Universitaire, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Daoudi","sequence":"additional","affiliation":[{"name":"University of Lille, Lille; INSERM 1190, European Genomics Institute for Diabetes (EGID), Lille, France"},{"name":"Cousin Biotech, Wervicq, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Solecki","sequence":"additional","affiliation":[{"name":"Cousin Biotech, Wervicq, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hubert","sequence":"additional","affiliation":[{"name":"University of Lille, Lille; INSERM 1190, European Genomics Institute for Diabetes (EGID), Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Quenon","sequence":"additional","affiliation":[{"name":"University of Lille, Lille; INSERM 1190, European Genomics Institute for Diabetes (EGID), Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Raverdy","sequence":"additional","affiliation":[{"name":"University of Lille, Lille; INSERM 1190, European Genomics Institute for Diabetes (EGID), Lille, France"},{"name":"Centre Hospitalier R\u00e9gional Universitaire, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Cousin","sequence":"additional","affiliation":[{"name":"Cousin Biotech, Wervicq, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Henin","sequence":"additional","affiliation":[{"name":"Cousin Biotech, Wervicq, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery","family":"Dalle","sequence":"additional","affiliation":[{"name":"Cousin Biotech, Wervicq, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Noel","sequence":"additional","affiliation":[{"name":"Cousin Biotech, Wervicq, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffroy","family":"Vanbiervliet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Public Assistance Hospitals of Marseille, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Barthet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Public Assistance Hospitals of Marseille, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Pattou","sequence":"additional","affiliation":[{"name":"University of Lille, Lille; INSERM 1190, European Genomics Institute for Diabetes (EGID), Lille, France"},{"name":"Centre Hospitalier R\u00e9gional Universitaire, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,12,1]]},"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-120439.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T02:03:53Z","timestamp":1513735433000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-120439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1055\/s-0043-120439","relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,1]]}}}