{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T01:28:13Z","timestamp":1720574893215},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"S 01","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngo-Rhino-Otol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>In den letzten Jahren wurden bedeutende Fortschritte auf dem Gebiet der Immuntherapie erreicht mit teils langanhaltendem Therapieansprechen bei unterschiedlichsten Tumorentit\u00e4ten. Die Basis hierf\u00fcr bildet ein verbessertes Verst\u00e4ndnis der Interaktion zwischen Tumor und Immunsystem und der damit verbundenen Integration immuntherapeutischer Ans\u00e4tze in die klinische Routine. Die hierbei eingesetzten immuntherapeutischen Strategien greifen auf unterschiedlichen Ebenen der Immunantwort ein, f\u00f6rdern direkt oder indirekt die Zerst\u00f6rung der Tumorzellen durch die k\u00f6rpereigene Abwehr und reichen von Zytokintherapien \u00fcber Vakzinierungen und den Einsatz onkolytischer Viren bis hin zu monoklonalen Antik\u00f6rpertherapien und dem adoptiven Zelltransfer.<\/jats:p>","DOI":"10.1055\/s-0043-121594","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T23:30:37Z","timestamp":1521761437000},"page":"S3-S47","source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["Immuntherapie \u2013 Die neue \u00c4ra in der Onkologie"],"prefix":"10.1055","volume":"97","author":[{"given":"Benjamin","family":"Kansy","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universit\u00e4tsklinikum Essen, Universit\u00e4t Duisburg-Essen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Lang","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universit\u00e4tsklinikum Essen, Universit\u00e4t Duisburg-Essen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,3,22]]},"container-title":["Laryngo-Rhino-Otologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-121594.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T20:15:31Z","timestamp":1557173731000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-121594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":0,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2018,3,22]]},"published-print":{"date-parts":[[2018,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-121594","relation":{},"ISSN":["0935-8943","1438-8685"],"issn-type":[{"value":"0935-8943","type":"print"},{"value":"1438-8685","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}