{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:52:31Z","timestamp":1757310751501},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>\nIntroduction Endocrine disorders of the pituitary axes are frequent in patients with hemodialysis (CKD5D). The aim of this multicenter study (Leipzig (L), Quedlinburg and Blankenburg in the Harz region (Hz)) in CKD5D patients was to evaluate influences of CKD5D related factors, morphological and biochemical parameters, and serum iodine and prolactin concentrations on the pituitary-thyroid axis.<\/jats:p>\nPatients and Methods 170 patients (L n=58; Hz n=112) were included in this prospective, non-interventional, cross-sectional study. Mann-Whitney-U-test and bivariate correlation analyses with Spearman-Rho test (r correlation coefficient) were used in statistical analysis.<\/jats:p>\nResults TSH was higher in patients with prolactin concentrations>370\u2009mIU\/l (p=0.013), in patients with high flux membranes (p=0.0013) and in patients with longer dialysis vintage (p=0.04). Median iodine serum concentrations were slightly elevated in the Leipzig cohort (p=0.001) and correlated with fT4 (p<0.001, r=0.43) and albumin (p=0.001, r=0.245) but not with morphological signs. Albumin was correlated with fT3 (p<0.001, r=0.339) and fT4 (p<0.001, r=0.421). Prolactin was correlated with residual excretion rate (p=0.001, r=- 0.303) and thyroid volume (p=0.027, r=0.217).<\/jats:p>\nConclusions In the assessment of the thyroid status in CKD5D patients, the synopsis of the clinical and nutritional status, comorbidities, ultrasound of the thyroid gland and laboratory results is necessary for further intervention with hormone replacement. Standardized reference values of the pituitary-thyroid axis should be critically evaluated and are still lacking in CKD5D.<\/jats:p>","DOI":"10.1055\/s-0043-123184","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T23:42:54Z","timestamp":1519429374000},"page":"349-356","source":"Crossref","is-referenced-by-count":2,"title":["The Pituitary-Thyroid Axis and Prolactin Secretion in Hemodialysis Patients in Two Endemic Regions of Eastern Germany"],"prefix":"10.1055","volume":"126","author":[{"given":"Franz","family":"Rasche","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Neurology, Dermatology, Clinic for Endocrinology, Diabetology and Nephrology, University Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronny","family":"Rettig","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Frese","sequence":"additional","affiliation":[{"name":"Institute of General Practice and Family Medicine, Medical Faculty, Martin Luther-University Halle-Wittenberg, Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma","family":"Rasche","sequence":"additional","affiliation":[{"name":"Department of Head Medicine and Oral Health, Department of Ophthalmology, University Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Barinka","sequence":"additional","affiliation":[{"name":"Center for Geriatric Medicine at Bezirksklinikum Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guenter","family":"Roesl","sequence":"additional","affiliation":[{"name":"Center for Geriatric Medicine at Bezirksklinikum Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frieder","family":"Keller","sequence":"additional","affiliation":[{"name":"Medical Department I, Nephrology Devision, University Hospital, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Neurology, Dermatology, Clinic for Endocrinology, Diabetology and Nephrology, University Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Schneider","sequence":"additional","affiliation":[{"name":"Translational & Experimental Medicine, Luxembourg Centre de Systems Biomedicine, Luxembourg"},{"name":"Department of Internal Medicine II, Saarland University, Homburg Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Beige","sequence":"additional","affiliation":[{"name":"Division of Nephrology and KfH Renal Unit, Hospital St. Georg, Leipzig, Germany, Martin-Luther-University Halle\/Wittenberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Ebert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Neurology, Dermatology, Clinic for Endocrinology, Diabetology and Nephrology, University Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Schiekofer","sequence":"additional","affiliation":[{"name":"Center for Geriatric Medicine at Bezirksklinikum Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,2,23]]},"container-title":["Experimental and Clinical Endocrinology & Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-123184.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T22:58:57Z","timestamp":1529017137000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-123184"}},"subtitle":["Morphologic and laboratory abnormalities of the thyroid gland in CKD5D patients"],"short-title":[],"issued":{"date-parts":[[2018,2,23]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2018,6,14]]},"published-print":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-123184","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,23]]}}}