{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T22:33:21Z","timestamp":1719441201791},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to investigate if there is a link between muscular strength (MS) and markers of chronic kidney disease (CKD) among older adults. The cross-sectional analysis based on 1041 men and women, aged 65\u201394 years, who participated in the KORA-Age study. Participants underwent an interview and extensive examinations including anthropometric measurements, diseases and drug intake registration, determination of health-related behaviors, collection of blood samples for measurements of cystatin C and maximal muscle strength evaluation. One-Way ANOVA revealed significant differences in both mean cystatin C (1.16\u00b10.37 vs. 1.03\u00b10.29 vs. 0.93\u00b10.24\u2009mg\/L, p&lt;0.001) and mean eGFRcysC (63.61\u00b118.61 vs. 72.14\u00b118.92 vs. 79.87\u00b118.19\u2009ml\/min\/1.73\u2009m2, p&lt;0.05) across thirds of maximal muscular strength (from lowest to highest). MS in the lowest third was significantly associated with increased odds of having elevated cystatin C (OR: 1.70, 95% CI: 1.01\u20132.85, p=0.043) after controlling for age, gender, fat mass, fat-free mass, alcohol intake, smoking status, number of regularly used medications, multimorbidity status, hs-CRP, telomere length and levels of physical activity. Lower levels of MS are independently associated with higher concentrations of cystatin C and lower eGFRcysC in older individuals. Increasing the levels of muscular strength may be useful to prevent the age-related CKD disease of older adults.<\/jats:p>","DOI":"10.1055\/s-0043-123649","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T23:34:37Z","timestamp":1520465677000},"page":"225-231","source":"Crossref","is-referenced-by-count":3,"title":["Muscular Strength is Independently Associated with Cystatin C: The KORA-Age Study"],"prefix":"10.1055","volume":"39","author":[{"given":"Konstantinos","family":"Volaklis","sequence":"additional","affiliation":[{"name":"Department of Prevention and Sports Medicine, Cardiac Rehabilitation Center, Augsburg, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Thorand","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anette","family":"Peters","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Halle","sequence":"additional","affiliation":[{"name":"Sports Medicine, Technical University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heier","family":"Margot","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Amann","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II, 3Institute of Epidemiology II, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Ladwig","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Schulz","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology I, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Koenig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II-Cardiology, University of Ulm, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"Meisinger","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,3,7]]},"container-title":["International Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-123649.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T23:34:43Z","timestamp":1520465683000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-123649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2018,3,7]]},"published-print":{"date-parts":[[2018,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-123649","relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}