{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T14:28:58Z","timestamp":1721399338447},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Einleitung Forschungsergebnisse zeigen Ver\u00e4nderungen des Darmmikrobioms bei Anorexia nervosa (AN). Die Alpha-Diversit\u00e4t (AD) repr\u00e4sentiert die Anzahl von Bakterienarten im Darm. Eine verminderte AD und erh\u00f6hte Darmpermeabilit\u00e4t (Zonulin) kann zu Inflammation und Ver\u00e4nderungen der N\u00e4hrstoffaufnahme f\u00fchren. Methoden AD wurde aus Stuhlproben von 18 AN-Patientinnen sowie 20 normalgewichtigen Kontrollen (NK) nach 16S RNA Sequenzierung ermittelt. Zus\u00e4tzlich wurden Zonulin als Marker der Darmbarriere und inflammatorische Parameter bestimmtErgebnisse AN-Patientinnen wiesen im Vergleich zu NK eine verminderte AD auf (Chao-1-Diversity: p=0.043, number of observed species p=0.042). Zonulin zeigte sich bei AN-Patientinnen im Vergleich zu NK nicht signifikant vermindert. Es gab keine Korrelationen zwischen den Serumparametern und AD. Diskussion AN-Patientinnen weisen unabh\u00e4ngig von der Darmpermeabilit\u00e4t eine erniedrigte AD auf. Die reduzierte AD kann die Kalorienaufnahme bei AN zus\u00e4tzlich negativ beeinflussen. Diese Ergebnisse tragen zu einem besseren Krankheitsverst\u00e4ndnis und der Entwicklung neuer Therapieoptionen bei.<\/jats:p>","DOI":"10.1055\/s-0043-123826","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T23:22:35Z","timestamp":1532647355000},"page":"39-45","source":"Crossref","is-referenced-by-count":9,"title":["Pilotstudie: Mikrobiom und Darmbarriere bei Anorexia nervosa"],"prefix":"10.1055","volume":"87","author":[{"given":"Sabrina","family":"M\u00f6rkl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Lackner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Meinitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Gorkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Kashofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Painold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Holl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Holasek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,7,26]]},"container-title":["Fortschritte der Neurologie \u00b7 Psychiatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-123826.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T23:42:16Z","timestamp":1551138136000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-123826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,26]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,2,25]]},"published-print":{"date-parts":[[2019,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-123826","relation":{},"ISSN":["0720-4299","1439-3522"],"issn-type":[{"value":"0720-4299","type":"print"},{"value":"1439-3522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,26]]}}}