{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T11:08:35Z","timestamp":1695640115319},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2002The frequency of autochthonous hepatitis E virus (HEV) infections in Western countries has increased since the millennium, probably due to a higher awareness for HEV. The aim of this study was to analyze the epidemiological situation and regional distribution of HEV in comparison to hepatitis A\u200a\u2013\u200aD in Germany.<\/jats:p><jats:p>\n          Methods\u2002Data of the reported cases, patients\u2019 travel histories, and the regional distribution of hepatitis A\u200a\u2013\u200aE virus infections from 2001 to 2017 were extracted from databases of the Robert Koch Institute. The number of publications per year on each hepatitis virus was used as a surrogate parameter for scientific awareness.<\/jats:p><jats:p>\n          Results\u2002The incidence of HEV infections increased from 31 reported cases in 2001 to 1991 cases in 2016 with a rate of autochthonous HEV infections of 44.4\u200a% in 2001 and 83.9\u200a% in 2016. In 2016, the HEV incidence was 4.4\/100\u200a000 in Eastern Germany and 2.0\/100\u200a000 in Western Germany. From 2001 to 2016, the numbers of hepatitis A and C virus infections decreased, while the number of hepatitis B virus infections initially decreased followed by an increase since 2014. The incidence of hepatitis D virus infections remained low. The incidence rates of hepatitis A\u200a\u2013\u200aD virus infections were comparable between Eastern and Western Germany in 2016. There was a strong correlation between publications on HEV and reported HEV cases (Pearson r\u200a=\u200a0.9803, p\u200a&lt;\u200a0.01).<\/jats:p><jats:p>\n          Conclusions\u2002Especially in Eastern Germany, but also in Western Germany, the rate of reported HEV cases and the scientific awareness for this disease increased strongly since 2001.<\/jats:p>","DOI":"10.1055\/s-0043-123830","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T18:43:27Z","timestamp":1515523407000},"page":"29-35","source":"Crossref","is-referenced-by-count":2,"title":["Time trend of reported cases and publications: hepatitis E in comparison to hepatitis A\u200a\u2013\u200aD in Germany from 2001 to 2016"],"prefix":"10.1055","volume":"56","author":[{"given":"Malte","family":"Wehmeyer","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Hartl","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"von Wulffen","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansgar","family":"Lohse","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf"},{"name":"Deutsches Zentrum f\u00fcr Infektionsforschung (DZIF), Hamburg site"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Pischke","sequence":"additional","affiliation":[{"name":"I. Department of Medicine, University Medical Center Hamburg-Eppendorf"},{"name":"Deutsches Zentrum f\u00fcr Infektionsforschung (DZIF), Hamburg site"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,1,9]]},"container-title":["Zeitschrift f\u00fcr Gastroenterologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-123830.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T04:13:18Z","timestamp":1532923998000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-123830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2017,12,1]]},"published-print":{"date-parts":[[2018,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-123830","relation":{},"ISSN":["0044-2771","1439-7803"],"issn-type":[{"value":"0044-2771","type":"print"},{"value":"1439-7803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}