{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:43:34Z","timestamp":1774964614990,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nIntroduction  One of the common side effects of antipsychotic drugs is excessive sedation. The treatment with antipsychotics often manifests as an increase in slow wave activity in electroencephalography (EEG). The aim of this study was to analyze EEG recordings of patients treated with a non-sedative antipsychotic drug sertindole with regard to its adverse effects and clinical efficacy.<\/jats:p><jats:p>\nPatients and methods  EEG recordings of 45 patients (27 females, mean age 30.1\u00b18.7 years) with schizophrenia were analyzed. EEG recordings were categorized based on abnormalities severity. The clinical efficacy was rated on the Clinical Global Impression Scale.<\/jats:p><jats:p>\nResults  Abnormalities from mild to moderate were found in 29% of the group. Clinical improvement was observed in 80% of patients. Sedation\/daytime sleepiness was present in 7% of patients. Other side effects were prolongation of QTc (11%, severe 4%), insomnia (9%), extrapyramidal symptoms (7%), and heart palpitations (2%).<\/jats:p><jats:p>\nConclusions  Patients treated with sertindole do not show side effects similar to those found during treatment with other antipsychotic drugs. Increased slow wave activity in EEG and sedation were absent in the majority of the investigated patients.<\/jats:p>","DOI":"10.1055\/s-0043-124372","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T00:45:39Z","timestamp":1515717939000},"page":"144-147","source":"Crossref","is-referenced-by-count":3,"title":["Sertindole: EEG Analysis, Tolerability, and Clinical Efficacy"],"prefix":"10.1055","volume":"51","author":[{"given":"Adam","family":"Kroc","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"D\u0119bicka","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Wierzbicka","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Wo\u0142kow","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Jernajczyk","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Wichniak","sequence":"additional","affiliation":[{"name":"Third Department of Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,1,11]]},"container-title":["Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-124372.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T23:03:53Z","timestamp":1530659033000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-124372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,11]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2018,7,3]]},"published-print":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-124372","relation":{},"ISSN":["0176-3679","1439-0795"],"issn-type":[{"value":"0176-3679","type":"print"},{"value":"1439-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,11]]}}}