{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:58:30Z","timestamp":1785344310419,"version":"3.55.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Although new image-enhanced endoscopy (IEE) technologies such as blue laser imaging (BLI), BLI-bright, and linked color imaging (LCI) have been developed, their utility for the detection of sessile serrated adenoma\/polyps (SSA\/Ps) is still unclear. This study aimed to evaluate the utility of BLI, BLI-bright, and LCI for SSA\/P detection in still image examinations and in a prospective randomized controlled trial (RCT).<\/jats:p><jats:p>\n          Patients and methods\u2002A group of 6 expert and non-expert endoscopists read 200 endoscopic still images containing SSA\/P lesions using white light image (WLI), BLI, BLI-bright, and LCI. Color differences were calculated using the color space method. A prospective RCT of tandem colonoscopy with WLI and LCI was performed. Patients with SSA\/P and those with a history of SSA\/P that had been endoscopically removed were enrolled and randomly allocated to WLI-LCI or LCI-WLI groups. Additional endoscopic detection rates for SSA\/P were compared between the 2 groups.<\/jats:p><jats:p>\n          Results\u2002LCI showed the highest SSA\/P detection rate among the 4 modes for both expert and non-expert endoscopists. The detection rate with LCI for the 6 expert endoscopists (mean 98.3\u200a\u00b1\u200astandard deviation 2.0\u200a%) was significantly higher than that with WLI (86.7\u200a\u00b1\u200a6.0\u200a%, P\u200a&lt;\u200a0.01). Likewise, the detection rate with LCI for the 6 non-expert endoscopists (92.3\u200a\u00b1\u200a2.9\u200a%) was significantly higher than that with WLI (72.7\u200a\u00b1\u200a11.5\u200a%, P\u200a&lt;\u200a0.01). The color difference of SSA\/P with LCI was the highest among the 4 modes, and was significantly higher than with WLI (median 15.9, (interquartile range 13.7\u200a\u2013\u200a20.6) vs. 10.2, (7.6\u200a\u2013\u200a14.2); P\u200a&lt;\u200a0.0001). In the RCT, a total of 44 patients (WLI-LCI 22 vs. LCI-WLI 22) underwent colonoscopy. The additional detection rate for SSA\/P in the second inspection in the WLI-LCI group (21.6\u00a0%, 8\/37) was significantly higher than in the LCI-WLI group (3.2\u200a%, 1\/31; P\u200a=\u200a0.02). The small, flat, non-mucus and isochromatic SSA\/Ps in the transverse colon were detected more frequently in the second inspection with LCI. <\/jats:p><jats:p>\n          Conclusions\u2002LCI was the most sensitive mode for SSA\/P detection among WLI, BLI, BLI-bright, and LCI in the still image examinations. Our RCT strongly suggests that LCI is superior to conventional WLI for SSA\/P detection during colonoscopy. UMIN000017599.<\/jats:p>","DOI":"10.1055\/s-0043-124469","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T23:57:32Z","timestamp":1520467052000},"page":"E322-E334","source":"Crossref","is-referenced-by-count":59,"title":["Linked color imaging enhances endoscopic detection of sessile serrated adenoma\/polyps"],"prefix":"10.1055","volume":"06","author":[{"given":"Daisaku","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Muguruma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuteru","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaizo","family":"Kagemoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Mitsui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Bando","sequence":"additional","affiliation":[{"name":"Division of Pathology, Tokushima University Hospital, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,3,7]]},"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-124469.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T20:13:22Z","timestamp":1557173602000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-124469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2018,2,28]]},"published-print":{"date-parts":[[2018,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-124469","relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}