{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:30:36Z","timestamp":1788543036268,"version":"build-2803163510"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Wear debris-induced osteolysis is one of the major reasons for subsequent aseptic loosening after cementless hip arthroplasty. Increasing evidence suggests that receptor activator of nuclear factor kappa-B (NF-\u03baB) ligand-mediated osteoclastogenesis and osteolysis are responsible for wear debris-induced aseptic loosening. In the present study, we explored the effect of amentoflavone (AMF) on inhibiting osteoclast generation and wear debris-induced osteolysis in vitro and in vivo. Twenty-four male C57BL\/J6 mice were randomly divided into four groups: a sham group and groups with titanium wear debris treatment followed by intraperitoneal injection of various concentrations of AMF (0, 20, and 40\u2009mg\/kg\/day). The micro computed tomography scanning and histological analysis were performed. Bone marrow-derived macrophages were cultured to investigate the effect of AMF on osteoclast generation and function. The results showed that AMF suppressed osteoclastogenesis, F-actin ring formation, and bone absorption without cytotoxicity. AMF prevented titanium wear debris-induced osteolysis in mice. AMF suppressed the relative proteins of NF-\u03baB and mitogen-activated protein kinase (MAPKs) signaling pathways. Thus, the present study suggests that AMF derived from plants could inhibit osteoclastogenesis and titanium wear debris-induced osteolysis via suppressing NF-\u03baB and MAPKs signaling pathways.<\/jats:p>","DOI":"10.1055\/s-0043-124594","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T18:45:01Z","timestamp":1515091501000},"page":"759-767","source":"Crossref","is-referenced-by-count":12,"title":["Amentoflavone Inhibits Osteoclastogenesis and Wear Debris-Induced Osteolysis via Suppressing NF-\u03baB and MAPKs Signaling Pathways"],"prefix":"10.1055","volume":"84","author":[{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dalian Medical University, Dalian, Liaoning, China"},{"name":"Department of Orthopedics, Subei People\u02bcs Hospital, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Xiangya Second Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Subei People\u02bcs Hospital, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, China"},{"name":"Xiangya Second Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dalian Medical University, Dalian, Liaoning, China"},{"name":"Department of Orthopedics, Subei People\u02bcs Hospital, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Subei People\u02bcs Hospital, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Subei People\u02bcs Hospital, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianqi","family":"Yan","sequence":"additional","affiliation":[{"name":"Dalian Medical University, Dalian, Liaoning, China"},{"name":"Department of Orthopedics, Subei People\u02bcs Hospital, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, China"},{"name":"Xiangya Second Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Subei People\u02bcs Hospital, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2018,1,4]]},"container-title":["Planta Medica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-124594.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T18:47:52Z","timestamp":1531334872000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-124594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,4]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,7,11]]},"published-print":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-124594","relation":{},"ISSN":["0032-0943","1439-0221"],"issn-type":[{"value":"0032-0943","type":"print"},{"value":"1439-0221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,4]]}}}