{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:43:42Z","timestamp":1782603822087,"version":"3.54.5"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nonosseous abnormalities are often seen on bone scans and can be related to a wide variety of pathology ranging across vascular, infection, and inflammatory etiology. Diffuse soft tissue radiotracer uptake on bone scans is typically attributed to renal or metabolic derangements. Calciphylaxis is the deposition of calcium in small blood vessels, skin, and other organs leading to vascular obstruction and skin necrosis. It is a rare disorder with unknown pathophysiology. Diagnosis of calciphylaxis is challenging and requires an interdisciplinary approach including clinical findings, laboratory results, medical imaging, and skin biopsy. An early diagnosis is important as the disease is associated with high morbidity and mortality. The purpose of this review article is to highlight the role of bone scintigraphy in the evaluation of calciphylaxis and to correlate the findings with other imaging modalities and histopathology.<\/jats:p>","DOI":"10.1055\/s-0043-1760760","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:37:56Z","timestamp":1706575076000},"page":"003-009","source":"Crossref","is-referenced-by-count":2,"title":["Potential Role of Bone Scintigraphy in the Diagnosis of Calciphylaxis"],"prefix":"10.1055","volume":"23","author":[{"given":"Khushboo","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nuclear Medicine Division, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7909-123X","authenticated-orcid":false,"given":"Pokhraj Prakashchandra","family":"Suthar","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetal","family":"Bhave","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagadeesh S.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhuja M. K.","family":"Venkatraman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rush University Medical Center, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul B.","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Department of Radiology, Neurointervention Radiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1681\/ASN.2007080854","article-title":"Mechanisms of vascular calcification in chronic kidney disease","volume":"19","author":"S M Moe","year":"2008","journal-title":"J Am Soc Nephrol"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1067\/mva.2003.70","article-title":"Calciphylaxis and nonhealing wounds: the role of the vascular surgeon in a multidisciplinary treatment","volume":"37","author":"M Milas","year":"2003","journal-title":"J Vasc Surg"},{"key":"ref3","first-page":"17","article-title":"A case of calcification of the arteries and obliterative endarteritis, associated with hydronephrosis, in a child aged six months","volume":"55","author":"J Bryant","year":"1898","journal-title":"Guys Hosp Rep"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.yexmp.2009.01.008","article-title":"Calciphylaxis cutis: a case report and review of literature","volume":"86","author":"M R Hussein","year":"2009","journal-title":"Exp Mol Pathol"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1525-139X.2002.00052.x","article-title":"Calciphylaxis: emerging concepts in prevention, diagnosis, and treatment","volume":"15","author":"W A Wilmer","year":"2002","journal-title":"Semin Dial"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4161\/oxim.3.2.11354","article-title":"Calcific uremic arteriolopathy: pathophysiology, reactive oxygen species and therapeutic approaches","volume":"3","author":"K M Sowers","year":"2010","journal-title":"Oxid Med Cell Longev"},{"issue":"04","key":"ref7","first-page":"161","article-title":"Acenocoumarol as a risk factor for calciphylaxis: a feature clinicians should be aware of","volume":"75","author":"E FE Wenstedt","year":"2017","journal-title":"Neth J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1525-139X.2002.00052.x","article-title":"Calciphylaxis: emerging concepts in prevention, diagnosis, and treatment","volume":"15","author":"W A Wilmer","year":"2002","journal-title":"Semin Dial"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1053\/ajkd.1998.v32.pm9740153","article-title":"Cutaneous necrosis from calcific uremic arteriolopathy","volume":"32","author":"T Coates","year":"1998","journal-title":"Am J Kidney Dis"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/MNH.0b013e32830f4566","article-title":"Calcific uraemic arteriolopathy: an update","volume":"17","author":"N M Rogers","year":"2008","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jaad.2007.12.006","article-title":"Pathogenesis of calciphylaxis: Hans Selye to nuclear factor kappa-B","volume":"58","author":"R H Weenig","year":"2008","journal-title":"J Am Acad Dermatol"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/DAD.0b013e31827c7f5d","article-title":"Cutaneous calciphylaxis: a retrospective histopathologic evaluation","volume":"35","author":"M C Mochel","year":"2013","journal-title":"Am J Dermatopathol"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1053\/j.ajkd.2015.01.034","article-title":"Calciphylaxis: risk factors, diagnosis, and treatment","volume":"66","author":"S U Nigwekar","year":"2015","journal-title":"Am J Kidney Dis"},{"issue":"09","key":"ref14","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.4103\/jfmpc.jfmpc_588_19","article-title":"Calciphylaxis and its diagnosis: a review","volume":"8","author":"D Baby","year":"2019","journal-title":"J Family Med Prim Care"},{"issue":"05","key":"ref15","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1111\/ijd.13043","article-title":"Calciphylaxis: a case series and the role of radiology in diagnosis","volume":"55","author":"J G Bonchak","year":"2016","journal-title":"Int J Dermatol"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/01.rlu.0000123326.07954.2a","article-title":"Visceral calcification diagnosed by bone scintigraphy","volume":"29","author":"M O Demirkol","year":"2004","journal-title":"Clin Nucl Med"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1046\/j.1523-1755.2002.00375.x","article-title":"Calciphylaxis is usually non-ulcerating: risk factors, outcome and therapy","volume":"61","author":"A Fine","year":"2002","journal-title":"Kidney Int"}],"container-title":["World Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1760760.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:48:08Z","timestamp":1730810888000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1760760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":17,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,4,8]]},"published-print":{"date-parts":[[2024,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1760760","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1450-1147","1607-3312"],"issn-type":[{"value":"1450-1147","type":"print"},{"value":"1607-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]}}}