{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:51:55Z","timestamp":1771462315774,"version":"3.50.1"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aim\u2003Primary central nervous system lymphoma (PCNSL) is a rare extra nodal non-Hodgkin's lymphoma. The optimal treatment for PCNSL is still unclear. In this study, we present our experience with management of PCNSL in a tertiary care center in Iran.<\/jats:p><jats:p>Methods\u2003In this retrospective study, 58 patients with tissue diagnosis of PCNSL were studied. All patients were treated with chemotherapy including intravenous high-dose methotrexate, rituximab and temozolomide and radiotherapy by the same oncologist. Statistical analysis was performed using SPSS.<\/jats:p><jats:p>Results\u2003The mean overall survival (OS) in this study was 37.4\u2009\u00b1\u200913.6 months and the mean progression free survival (PFS) was 35.1\u2009\u00b1\u20099.8 months. The mean time to progression was 15.2\u2009\u00b1\u20098.79 months among 8 patients who experienced progression in this series. Finding of a positive CSF cytology was not linked with disease progression, while HIV infection and multifocal involvement at initial presentation were strongly linked to a lower PFS. The single most important factor affecting the OS was the histopathologic type of the PCNSL; two of the three patients who died from their disease in this series had non-B cell PCNSL, whereas only one patient with DLBCL died because of brainstem involvement.<\/jats:p><jats:p>Conclusion\u2003The results of this study show a lower rate of HIV-infection in patients with PCNSL as compared to the series from the western countries. Non-B cell histopathology and HIV-infection were found to be associated with the dismal prognosis.<\/jats:p>","DOI":"10.1055\/s-0043-1761229","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T23:03:26Z","timestamp":1679958206000},"page":"036-039","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Factors of the Primary Central Nervous System Lymphoma: Clinical Experience from a Tertiary Care Center in the Middle East"],"prefix":"10.1055","volume":"18","author":[{"given":"Hannan","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Esfandbod","sequence":"additional","affiliation":[{"name":"Department of Hematology-Oncology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Mehdi","family":"Ketabchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kourosh Karimi","family":"Yarandi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Shirani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Amirjamshidi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maysam","family":"Alimohamadi","sequence":"additional","affiliation":[{"name":"Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00277-019-03821-9","article-title":"Primary central nervous system lymphoma in China: a single-center retrospective analysis of 167 cases","volume":"99","author":"X G Yuan","year":"2020","journal-title":"Ann Hematol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jns.2019.03.011","article-title":"Seizures in patents 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