{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:40:02Z","timestamp":1730814002762,"version":"3.28.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003Despite improvements in our ability for early diagnosis and providing supportive care for infants with gastroschisis, it continues to be associated with long length of stay and morbidity. Intestinal dysfunction secondary to chronic inflammatory insult to exposed bowel is well known; however, little research has been done on the impact of acute inflammation in the perinatal period on intestinal function. This study's aim was to investigate the impact of acute chorioamnionitis on the time to achieve full enteral feeds and length of hospital stay.<\/jats:p><jats:p>\n            Study Design\u2003Retrospective chart review of 60 mothers and their infants born with gastroschisis at a Level IV NICU from November 2011 to June 2020 was performed. Infants were divided into two groups based on the presence of histologic chorioamnionitis, and outcomes were compared. The primary outcome was delayed full enteral feeds (full enteral feeds after 28 days of life). The secondary outcomes were differences in their time to achieve full enteral feeds and time to hospital discharge, and prolonged length of hospital stay (discharge after 30 days of life). Univariate and multivariate logistic regression analyses were performed to assess the association between the dependent and the predictor variables.<\/jats:p><jats:p>\n            Result\u2003Of the 60 infants enrolled, 23 (38%) had evidence of histologic chorioamnionitis. The median gestational age was 37 weeks. Fifty-four (90%) infants achieved full enteral feeds, with a median time of 24 days. Median length of hospital stay was 31 days. The presence of histologic chorioamnionitis was not associated with delayed full enteral feeds (odds ratio [OR]\u2009=\u20090.79; 95% confidence interval [CI]\u2009=\u20090.14\u20134.23; p\u2009=\u20090.80) or prolonged length of hospital stay (OR\u2009=\u20090.45; 95% CI\u2009=\u20090.1\u20130.23; p\u2009=\u20090.32) in the adjusted analysis.<\/jats:p><jats:p>\n            Conclusion\u2003Acute placental inflammation during the perinatal period does not impact the infant's time to achieve full feeds or prolong their hospital stay. Larger studies are needed to confirm these findings.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0043-1761298","type":"journal-article","created":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T23:34:00Z","timestamp":1675035240000},"page":"e1220-e1227","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Gastroschisis Outcomes: Presence of Histologic Chorioamnionitis and the Impact on Time to Full Enteral Feeds and Length of Hospital Stay"],"prefix":"10.1055","volume":"41","author":[{"given":"Chukwudi O.","family":"Ejiofor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Neonatal-Perinatal Medicine), Franciscan Missionaries of Our Lady Health System, Lafayette, Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Ford","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of South Florida College of Medicine, Tampa, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose R.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drew","family":"Rideout","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, Johns Hopkins All Children's Hospital, St Petersburg, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambuj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyur","family":"Donda","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of South Florida College of Medicine, Tampa, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Flores-Torres","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of South Florida College of Medicine, Tampa, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/OGX.0000000000000344","article-title":"Gastroschisis: a review of management and outcomes","volume":"71","author":"R V O'Connell","year":"2016","journal-title":"Obstetrical Gynecol Surg"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/MOP.0000000000000336","article-title":"Management of gastroschisis","volume":"28","author":"E D Skarsgard","year":"2016","journal-title":"Curr Opin Pediatr"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.15585\/mmwr.mm6502a2","article-title":"Increasing prevalence of gastroschisis\u201414 states, 1995\u20132012","volume":"65","author":"A M Jones","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/AOG.0b013e31829cbbb4","article-title":"Prevalence and correlates of gastroschisis in 15 states, 1995 to 2005","volume":"122","author":"R S Kirby","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/AOG.0000000000000425","article-title":"Factors associated with gastroschisis outcomes","volume":"124","author":"R T Overcash","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/j.jpedsurg.2006.06.010","article-title":"Intestinal transplantation for short bowel syndrome secondary to gastroschisis","volume":"41","author":"M Wada","year":"2006","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/jpen.2112","article-title":"Twelve-year outcomes of intestinal failure-associated liver disease in children with short-bowel syndrome: 97% transplant-free survival and 81% enteral autonomy","volume":"46","author":"C Torres","year":"2022","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/jpen.2124","article-title":"In neonatal-onset surgical short bowel syndrome survival is high, and enteral autonomy is related to residual bowel length","volume":"46","author":"R Fatemizadeh","year":"2022","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1203\/01.pdr.0000242344.22638.94","article-title":"Biochemical investigations of bowel inflammation in gastroschisis","volume":"60","author":"J Guibourdenche","year":"2006","journal-title":"Pediatr Res"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/j.1471-0528.1998.tb09975.x","article-title":"Intra-amniotic inflammation in human gastroschisis: possible aetiology of postnatal bowel dysfunction","volume":"105","author":"J J Morrison","year":"1998","journal-title":"Br J Obstet Gynaecol"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.4049\/jimmunol.1502587","article-title":"Heightened immune activation in fetuses with gastroschisis may be blocked by targeting IL-5","volume":"196","author":"M Frascoli","year":"2016","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.ajog.2015.08.040","article-title":"Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance","volume":"213","author":"C J Kim","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"531543","DOI":"10.3389\/fimmu.2020.531543","article-title":"Maternal-fetal inflammation in the placenta and the developmental origins of health and disease","volume":"11","author":"J A Goldstein","year":"2020","journal-title":"Front Immunol"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pedneo.2013.05.007","article-title":"Effects of placental inflammation on neonatal outcome in preterm infants","volume":"55","author":"Z Liu","year":"2014","journal-title":"Pediatr Neonatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3109\/14767058.2012.663161","article-title":"Chorioamnionitis\u2013the good or the evil for neonatal outcome?","volume":"25","author":"I Bersani","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"e891","DOI":"10.1542\/peds.2009-0313","article-title":"Placental inflammatory response is associated with poor neonatal growth: preterm birth cohort study","volume":"125","author":"K Mestan","year":"2010","journal-title":"Pediatrics"},{"issue":"05","key":"ref17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10024-003-7070-y","article-title":"Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns","volume":"6","author":"R W Redline","year":"2003","journal-title":"Pediatr Dev Pathol"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jpedsurg.2015.02.029","article-title":"Interstitial cells of Cajal are decreased in patients with gastroschisis associated intestinal dysmotility","volume":"50","author":"E Zani-Ruttenstock","year":"2015","journal-title":"J Pediatr Surg"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0022-3468(89)80200-3","article-title":"Etiology of intestinal damage in gastroschisis. I: effects of amniotic fluid exposure and bowel constriction in a fetal lamb model","volume":"24","author":"J C Langer","year":"1989","journal-title":"J Pediatr Surg"},{"issue":"03","key":"ref20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0022-3468(95)90036-5","article-title":"Etiology of intestinal damage in gastroschisis. III: morphometric analysis of the smooth muscle and submucosa","volume":"30","author":"S K Srinathan","year":"1995","journal-title":"J Pediatr Surg"},{"issue":"07","key":"ref21","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/0022-3468(91)90138-J","article-title":"An improved model of experimental gastroschisis in fetal rabbits","volume":"26","author":"J D Phillips","year":"1991","journal-title":"J Pediatr Surg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"155406","DOI":"10.1016\/j.cyto.2020.155406","article-title":"Multiple cytokine analysis in gastroschisis: association with adverse outcomes including fetal brain damage","volume":"138","author":"T Owaki","year":"2021","journal-title":"Cytokine"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.jpedsurg.2005.08.032","article-title":"Can levels of interleukins and matrix metalloproteinases in the amniotic fluid predict postnatal bowel function in fetuses with gastroschisis?","volume":"40","author":"G Fasching","year":"2005","journal-title":"J Pediatr Surg"},{"issue":"09","key":"ref24","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.jpedsurg.2008.03.053","article-title":"Mode of delivery and neonatal survival of infants with gastroschisis in Australia and New Zealand","volume":"43","author":"M E Abdel-Latif","year":"2008","journal-title":"J Pediatr Surg"},{"issue":"04","key":"ref25","doi-asserted-by":"crossref","first-page":"F355","DOI":"10.1136\/archdischild-2016-312394","article-title":"Mode of delivery and outcomes of infants with gastroschisis: a meta-analysis of observational studies","volume":"103","author":"D W Kirollos","year":"2018","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"03","key":"ref26","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/ppe.12554","article-title":"Mode of delivery and mortality among neonates with gastroschisis: a population-based cohort in Texas","volume":"33","author":"A Lopez","year":"2019","journal-title":"Paediatr Perinat Epidemiol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1761298.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:22:00Z","timestamp":1730812920000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1761298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,29]]},"references-count":26,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1761298","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"type":"print","value":"0735-1631"},{"type":"electronic","value":"1098-8785"}],"subject":[],"published":{"date-parts":[[2023,1,29]]}}}