{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:49:06Z","timestamp":1781815746254,"version":"3.54.5"},"reference-count":58,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["Project number 374031971-TRR 240"],"award-info":[{"award-number":["Project number 374031971-TRR 240"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement","award":["No. 766118 (TAPAS)"],"award-info":[{"award-number":["No. 766118 (TAPAS)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>\n            Background\u2003In secondary cardiovascular disease prevention, treatments blocking platelet-derived secondary mediators pose a risk of bleeding. Pharmacological interference of the interaction of platelets with exposed vascular collagens is an attractive alternative, with clinical trials ongoing. Antagonists of the collagen receptors, glycoprotein VI (GPVI), and integrin \u03b12\u03b21, include recombinant GPVI-Fc dimer construct Revacept, 9O12\u2009mAb based on the GPVI-blocking reagent Glenzocimab, Syk tyrosine-kinase inhibitor PRT-060318, and anti-\u03b12\u03b21\u2009mAb 6F1. No direct comparison has been made of the antithrombic potential of these drugs.<\/jats:p><jats:p>\n            Methods\u2003Using a multiparameter whole-blood microfluidic assay, we compared the effects of Revacept, 9O12-Fab, PRT-060318, or 6F1\u2009mAb intervention with vascular collagens and collagen-related substrates with varying dependencies on GPVI and \u03b12\u03b21. To inform on Revacept binding to collagen, we used fluorescent-labelled anti-GPVI nanobody-28.<\/jats:p><jats:p>\n            Results and Conclusion\u2003In this first comparison of four inhibitors of platelet\u2013collagen interactions with antithrombotic potential, we find that at arterial shear rate: (1) the thrombus-inhibiting effect of Revacept was restricted to highly GPVI-activating surfaces; (2) 9O12-Fab consistently but partly inhibited thrombus size on all surfaces; (3) effects of GPVI-directed interventions were surpassed by Syk inhibition; and (4) \u03b12\u03b21-directed intervention with 6F1\u2009mAb was strongest for collagens where Revacept and 9O12-Fab were limitedly effective. Our data hence reveal a distinct pharmacological profile for GPVI-binding competition (Revacept), GPVI receptor blockage (9O12-Fab), GPVI signaling (PRT-060318), and \u03b12\u03b21 blockage (6F1\u2009mAb) in flow-dependent thrombus formation, depending on the platelet-activating potential of the collagen substrate. This work thus points to additive antithrombotic action mechanisms of the investigated drugs.<\/jats:p>","DOI":"10.1055\/s-0043-1761463","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T23:42:20Z","timestamp":1676677340000},"page":"597-612","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacological Inhibition of Glycoprotein VI- and Integrin \u03b12\u03b21-Induced Thrombus Formation Modulated by the Collagen Type"],"prefix":"10.1055","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2314-4993","authenticated-orcid":false,"given":"Natalie J.","family":"Jooss","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands"},{"name":"Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M.C.","family":"Henskens","sequence":"additional","affiliation":[{"name":"Central Diagnostic Laboratory, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve P.","family":"Watson","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom"},{"name":"Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Midlands, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6130-8808","authenticated-orcid":false,"given":"Richard W.","family":"Farndale","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom"},{"name":"CambCol Laboratories, Ely, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinrad P.","family":"Gawaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Hospital T\u00fcbingen, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Jandrot-Perrus","sequence":"additional","affiliation":[{"name":"UMR_S1148, Laboratory for Vascular Translational Science, INSERM, University Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie S.","family":"Poulter","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom"},{"name":"Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Midlands, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2848-5121","authenticated-orcid":false,"given":"Johan W. M.","family":"Heemskerk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands"},{"name":"Synapse Research Institute, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"issue":"S 01","key":"ref1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1538-7836.2011.04361.x","article-title":"Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke","volume":"9","author":"B Nieswandt","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet biology and functions: new concepts and clinical perspectives","volume":"16","author":"P EJ van der Meijden","year":"2019","journal-title":"Nat Rev Cardiol"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41573-021-00198-1","article-title":"Targeting inflammation in atherosclerosis - from experimental insights to the clinic","volume":"20","author":"O Soehnlein","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"107630","DOI":"10.1016\/j.pharmthera.2020.107630","article-title":"Glycoprotein VI - novel target in antiplatelet medication","volume":"217","author":"O Borst","year":"2021","journal-title":"Pharmacol Ther"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/rth2.12092","article-title":"Glycoprotein VI in securing vascular integrity in inflamed vessels","volume":"2","author":"Y Boulaftali","year":"2018","journal-title":"Res Pract Thromb Haemost"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI122955","article-title":"Functional significance of the platelet immune receptors GPVI and CLEC-2","volume":"129","author":"J Rayes","year":"2019","journal-title":"J Clin Invest"},{"issue":"24","key":"ref7","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1182\/blood-2018-02-831982","article-title":"A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding","volume":"132","author":"C CFMJ Baaten","year":"2018","journal-title":"Blood"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41573-020-0061-0","article-title":"Therapeutic strategies for thrombosis: new targets and approaches","volume":"19","author":"N Mackman","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"ref9","first-page":"59","article-title":"Targeting GPVI as a novel antithrombotic strategy","volume":"5","author":"R K Andrews","year":"2014","journal-title":"J Blood Med"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1080\/09537104.2019.1610166","article-title":"Platelet glycoprotein VI genetic quantitative and qualitative defects","volume":"30","author":"M Jandrot-Perrus","year":"2019","journal-title":"Platelets"},{"issue":"13","key":"ref11","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1182\/bloodadvances.2020001761","article-title":"Flow studies on human GPVI-deficient blood under coagulating and noncoagulating conditions","volume":"4","author":"M Nagy","year":"2020","journal-title":"Blood Adv"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1182\/blood-2002-12-3882","article-title":"Platelet-collagen interaction: is GPVI the central receptor?","volume":"102","author":"B Nieswandt","year":"2003","journal-title":"Blood"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"e0247425","DOI":"10.1371\/journal.pone.0247425","article-title":"Long-term platelet priming after glycoprotein VI stimulation in comparison to protease-activating receptor (PAR) stimulation","volume":"16","author":"J Zou","year":"2021","journal-title":"PLoS One"},{"issue":"15","key":"ref14","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1161\/CIRCULATIONAHA.114.015036","article-title":"Coordinated membrane ballooning and procoagulant spreading in human platelets","volume":"132","author":"E O Agbani","year":"2015","journal-title":"Circulation"},{"issue":"24","key":"ref15","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1182\/blood-2010-01-260778","article-title":"Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood","volume":"115","author":"N Pugh","year":"2010","journal-title":"Blood"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.3390\/ijms20112788","article-title":"Role of platelet glycoprotein VI and tyrosine kinase Syk in thrombus formation on collagen-like surfaces","volume":"20","author":"N J Jooss","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1161\/ATVBAHA.120.314641","article-title":"Nonredundant roles of platelet glycoprotein VI and integrin \u03b1IIb\u03b23 in fibrin-mediated microthrombus formation","volume":"41","author":"G Perrella","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/318470a0","article-title":"Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia","volume":"318","author":"H K Nieuwenhuis","year":"1985","journal-title":"Nature"},{"issue":"13","key":"ref19","doi-asserted-by":"crossref","first-page":"10789","DOI":"10.1074\/jbc.M112307200","article-title":"Integrin \u03b1 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen","volume":"277","author":"O Holtk\u00f6tter","year":"2002","journal-title":"J Biol Chem"},{"issue":"07","key":"ref20","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1096\/fj.04-1940fje","article-title":"Adhesion of human and mouse platelets to collagen under shear: a unifying model","volume":"19","author":"J M Auger","year":"2005","journal-title":"FASEB J"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1182\/blood-2004-11-4434","article-title":"GPVI and \u03b12\u03b21 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow","volume":"106","author":"K L Sarratt","year":"2005","journal-title":"Blood"},{"issue":"09","key":"ref22","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1161\/01.ATV.0000137974.85068.93","article-title":"Principal role of glycoprotein VI in \u03b12\u03b21 and alphaIIbbeta3 activation during collagen-induced thrombus formation","volume":"24","author":"C Lecut","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"08","key":"ref23","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1160\/TH16-12-0906","article-title":"Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions","volume":"117","author":"N Pugh","year":"2017","journal-title":"Thromb Haemost"},{"issue":"03","key":"ref24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jacbts.2016.03.008","article-title":"Cross-linking GPVI-Fc by anti-Fc antibodies potentiates its inhibition of atherosclerotic plaque- and collagen-induced platelet activation","volume":"1","author":"J Jamasbi","year":"2016","journal-title":"JACC Basic Transl Sci"},{"issue":"08","key":"ref25","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1160\/TH16-11-0856","article-title":"Recombinant GPVI-Fc added to single or dual antiplatelet therapy in vitro prevents plaque-induced platelet thrombus formation","volume":"117","author":"A K Mojica Mu\u00f1oz","year":"2017","journal-title":"Thromb Haemost"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1096\/fj.03-0464fje","article-title":"Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo","volume":"18","author":"S Massberg","year":"2004","journal-title":"FASEB J"},{"issue":"04","key":"ref27","doi-asserted-by":"crossref","first-page":"e393","DOI":"10.1055\/s-0040-1721078","article-title":"Revacept, an inhibitor of platelet adhesion in symptomatic carotid artery stenosis: design and rationale of a randomized phase II clinical trial","volume":"4","author":"K Gr\u00f6schel","year":"2020","journal-title":"TH Open"},{"issue":"07","key":"ref28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/jamacardio.2021.0475","article-title":"Efficacy and safety of revacept, a novel lesion-directed competitive antagonist to platelet glycoprotein VI, in patients undergoing elective percutaneous coronary intervention for stable ischemic heart disease: the randomized, double-blind, placebo-controlled ISAR-PLASTER phase 2 trial","volume":"6","author":"K Mayer","year":"2021","journal-title":"JAMA Cardiol"},{"issue":"05","key":"ref29","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1161\/ATVBAHA.118.312314","article-title":"Safety and tolerability, pharmacokinetics, and pharmacodynamics of ACT017, an antiplatelet GPVI (glycoprotein VI) Fab","volume":"39","author":"C Voors-Pette","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"07","key":"ref30","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.3324\/haematol.2020.270439","article-title":"Glenzocimab does not impact glycoprotein VI-dependent inflammatory haemostasis","volume":"106","author":"S Jadoui","year":"2021","journal-title":"Haematologica"},{"issue":"05","key":"ref32","doi-asserted-by":"crossref","first-page":"898","DOI":"10.3324\/haematol.2017.182972","article-title":"Immobilized fibrinogen activates human platelets through glycoprotein VI","volume":"103","author":"P H Mangin","year":"2018","journal-title":"Haematologica"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"ehab724.1425","DOI":"10.1093\/eurheartj\/ehab724.1425","article-title":"GPVI inhibition by glenzocimab synergistically inhibits atherosclerotic plaque-induced platelet activation when combined with conventional dual antiplatelet therapy","volume":"42","author":"F O Alenazy","year":"2021","journal-title":"Eur Heart J"},{"issue":"08","key":"ref34","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1096\/fj.04-2748com","article-title":"Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI","volume":"19","author":"S Penz","year":"2005","journal-title":"FASEB J"},{"issue":"06","key":"ref35","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3324\/haematol.2018.198853","article-title":"High-throughput elucidation of thrombus formation reveals sources of platelet function variability","volume":"104","author":"J P van Geffen","year":"2019","journal-title":"Haematologica"},{"issue":"03","key":"ref36","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1182\/blood-2003-01-0308","article-title":"Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody","volume":"103","author":"P A Smethurst","year":"2004","journal-title":"Blood"},{"issue":"30","key":"ref38","doi-asserted-by":"crossref","first-page":"23410","DOI":"10.1074\/jbc.M110.136176","article-title":"Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen","volume":"285","author":"K Gilio","year":"2010","journal-title":"J Biol Chem"},{"issue":"24","key":"ref39","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1182\/blood.2020009440","article-title":"Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer","volume":"137","author":"A Slater","year":"2021","journal-title":"Blood"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1038\/ncomms5257","article-title":"Identification of platelet function defects by multi-parameter assessment of thrombus formation","volume":"5","author":"S M de Witt","year":"2014","journal-title":"Nat Commun"},{"issue":"15","key":"ref41","doi-asserted-by":"crossref","first-page":"8688","DOI":"10.3390\/ijms23158688","article-title":"Roles of focal adhesion kinase PTK2 and integrin \u03b1IIb\u03b23 signaling in collagen- and GPVI-dependent thrombus formation under shear","volume":"23","author":"J Huang","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"12","key":"ref42","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1111\/j.1538-7836.2008.03167.x","article-title":"Collagen-mimetic peptides mediate flow-dependent thrombus formation by high- or low-affinity binding of integrin \u03b12\u03b21 and glycoprotein VI","volume":"6","author":"I C Munnix","year":"2008","journal-title":"J Thromb Haemost"},{"issue":"10","key":"ref43","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1182\/blood.V88.10.3862.bloodjournal88103862","article-title":"Platelet adhesion to collagen type IV under flow conditions","volume":"88","author":"G Henrita van Zanten","year":"1996","journal-title":"Blood"},{"issue":"17","key":"ref44","doi-asserted-by":"crossref","first-page":"11044","DOI":"10.1074\/jbc.272.17.11044","article-title":"The platelet reactivity of synthetic peptides based on the collagen III fragment \u03b11(III)CB4. Evidence for an integrin \u03b12\u03b21 recognition site involving residues 522-528 of the \u03b11(III) collagen chain","volume":"272","author":"L F Morton","year":"1997","journal-title":"J Biol Chem"},{"issue":"04","key":"ref45","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1538-7836.2004.00665.x","article-title":"The role of collagen in thrombosis and hemostasis","volume":"2","author":"R W Farndale","year":"2004","journal-title":"J Thromb Haemost"},{"issue":"05","key":"ref46","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0092-8674(00)81607-4","article-title":"Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow","volume":"94","author":"B Savage","year":"1998","journal-title":"Cell"},{"issue":"01","key":"ref47","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1080\/09537100701609027","article-title":"Collagen-type specificity of glycoprotein VI as a determinant of platelet adhesion","volume":"19","author":"S M Jung","year":"2008","journal-title":"Platelets"},{"issue":"03","key":"ref48","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/jth.13613","article-title":"Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets","volume":"15","author":"N S Poulter","year":"2017","journal-title":"J Thromb Haemost"},{"issue":"11","key":"ref49","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1111\/jth.15836","article-title":"Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling, and thrombus formation","volume":"20","author":"N J Jooss","year":"2022","journal-title":"J Thromb Haemost"},{"issue":"17","key":"ref50","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1161\/CIRCULATIONAHA.110.980623","article-title":"Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans","volume":"123","author":"M Ungerer","year":"2011","journal-title":"Circulation"},{"issue":"01","key":"ref51","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3390\/ijms23010358","article-title":"Temporal roles of platelet and coagulation pathways in collagen- and tissue factor-induced thrombus formation","volume":"23","author":"S Navarro","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"20","key":"ref52","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1007\/s00018-012-1033-2","article-title":"Key role of integrin \u03b1IIb\u03b23 signaling to Syk kinase in tissue factor-induced thrombin generation","volume":"69","author":"P E van der Meijden","year":"2012","journal-title":"Cell Mol Life Sci"},{"issue":"09","key":"ref53","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1093\/emboj\/20.9.2120","article-title":"Glycoprotein VI but not \u03b12\u03b21 integrin is essential for platelet interaction with collagen","volume":"20","author":"B Nieswandt","year":"2001","journal-title":"EMBO J"},{"issue":"10","key":"ref54","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1182\/blood-2003-04-1323","article-title":"The contributions of the \u03b1 2 \u03b2 1 integrin to vascular thrombosis in vivo","volume":"102","author":"L He","year":"2003","journal-title":"Blood"},{"issue":"01","key":"ref55","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1158\/1078-0432.CCR-10-0010","article-title":"Phase I study of E7820, an oral inhibitor of integrin \u03b1-2 expression with antiangiogenic properties, in patients with advanced malignancies","volume":"17","author":"M Mita","year":"2011","journal-title":"Clin Cancer Res"},{"issue":"04","key":"ref56","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00395-008-0722-3","article-title":"Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo","volume":"103","author":"C Schulz","year":"2008","journal-title":"Basic Res Cardiol"},{"issue":"24","key":"ref57","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1182\/blood-2017-09-808808","article-title":"Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque-triggered thrombus formation in humans","volume":"131","author":"K Busygina","year":"2018","journal-title":"Blood"},{"issue":"01","key":"ref58","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/09537104.2020.1849600","article-title":"Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases","volume":"32","author":"M H Harbi","year":"2021","journal-title":"Platelets"},{"issue":"05","key":"ref59","first-page":"508","article-title":"Transitioning from thrombopoietin agonists to the novel Syk inhibitor fostamatinib: a multicenter, real-world case series","volume":"12","author":"D M Hughes","year":"2021","journal-title":"J Adv Pract Oncol"},{"issue":"09","key":"ref60","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/jcph.1616","article-title":"Population pharmacokinetic\/pharmacodynamic modeling of glenzocimab (ACT017) a glycoprotein VI inhibitor of collagen-induced platelet aggregation","volume":"60","author":"L Renaud","year":"2020","journal-title":"J Clin Pharmacol"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1761463.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T23:43:07Z","timestamp":1684885387000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1761463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,17]]},"references-count":58,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2023,5,23]]},"published-print":{"date-parts":[[2023,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1761463","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,17]]}}}