{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:14Z","timestamp":1740126794403,"version":"3.37.3"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose\u2003Defining focality of febrile seizures (FS) in clinical practice remains controversial. We investigated focality issues in FS with a postictal arterial spin labeling (ASL) sequence.<\/jats:p><jats:p>\n          Methods\u2003We retrospectively reviewed 77 children (median: 19.0 months, range: 15.0\u201333.0 months) who consecutively visited our emergency room for FS and underwent brain magnetic resonance imaging (MRI), including the ASL sequence, within 24\u2009hours of seizure onset. ASL data were visually analyzed to assess perfusion changes. Factors related to the perfusion changes were investigated.<\/jats:p><jats:p>\n          Results\u2003The mean time to ASL acquisition was 7.0 (interquartile range: 4.0\u201311.0) hours. The most common seizure classification was unknown-onset seizures (n\u2009=\u200937, 48%), followed by focal-onset (n\u2009=\u200926, 34%) and generalized-onset seizures (n\u2009=\u200914, 18%). Perfusion changes were observed in 43 (57%) patients: most were hypoperfusion (n\u2009=\u200935, 83%). The temporal regions were the most common location of perfusion changes (n\u2009=\u200926, 60%); the majority of these were distributed in the unilateral hemisphere. Perfusion changes were independently associated with seizure classification (focal-onset seizures, adjusted odds ratio [aOR]: 9.6, p\u2009=\u20090.01; unknown-onset seizures aOR: 10.4, p\u2009&lt;\u20090.01), and prolonged seizures (aOR: 3.1, p\u2009=\u20090.04), but not with other factors (age, sex, time to MRI acquisition, previous FS, repeated FS within 24\u2009hour, family history of FS, structural abnormality on MRI, and developmental delay). The focality scale of seizure semiology positively correlated with perfusion changes (R\u2009=\u20090.334, p\u2009&lt;\u20090.01).<\/jats:p><jats:p>\n          Conclusion\u2003Focality in FS may be common, and its primary origin might be the temporal regions. ASL can be useful for assessing focality in FS, particularly when seizure onset is unknown.<\/jats:p>","DOI":"10.1055\/s-0043-1761922","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:04:50Z","timestamp":1677542690000},"page":"197-205","source":"Crossref","is-referenced-by-count":0,"title":["Focality in Febrile Seizures: A Retrospective Assessment Using Arterial Spin Labeling MRI"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0688-7493","authenticated-orcid":false,"given":"Jung Sook","family":"Yeom","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University of Hospital, Jinju, South Korea"},{"name":"Gyeongsang National University College of Medicine, Institute of Health Science, Jinju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Gyeongsang National University College of Medicine, Institute of Health Science, Jinju, South Korea"},{"name":"Department of Neurology, Gyeongsang National University of Hospital, Jinju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Seob","family":"Choi","sequence":"additional","affiliation":[{"name":"Gyeongsang National University College of Medicine, Institute of Health Science, Jinju, South Korea"},{"name":"Department of Radiology, Gyeongsang National University of Hospital, Jinju, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/bmj.303.6814.1373","article-title":"Risk of epilepsy after febrile convulsions: a national cohort study","volume":"303","author":"C M 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