{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T05:09:03Z","timestamp":1783228143689,"version":"3.54.6"},"reference-count":23,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Focal and segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome in both adults and children. The \u201cColumbia classification of FSGS\u201d includes five variants; not otherwise specified (NOS), tip, perihilar, cellular, and collapsing variants that may have different prognostic and therapeutic implications.<\/jats:p><jats:p>\n          Materials and Methods\u2003This is a retrospective study and was carried out in the Department of Histopathology, Apollo Hospitals, Hyderabad. Of a total of 11,691 kidney biopsies over a 7-year period, from 2006 to 2012, 824 cases were diagnosed as FSGS, of which 610 cases in which detailed clinical findings were available were included in this study. FSGS was then categorized according to the Columbia classification.<\/jats:p><jats:p>\n          Results\u2003FSGS, NOS was the predominant histomorphological variant. Serum creatinine was significantly high in the collapsing variant, followed by NOS. Follow-up data was available for 103 cases,72.8% had complete remission, 10.6% had partial remission, and in 16.5\u2009% there was no remission. Relapses were observed in 6.7% cases, two patients (1.9%) succumbed, and 4.8% cases progressed to chronic kidney disease.<\/jats:p><jats:p>\n          Conclusion\u2003This study showed that perihilar variant was less prevalent, with tip and cellular variants being more prevalent in Indian subcontinent compared to Western literature. Collapsing variant was also less common.<\/jats:p>","DOI":"10.1055\/s-0043-1761930","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:03:35Z","timestamp":1677283415000},"page":"431-436","source":"Crossref","is-referenced-by-count":3,"title":["A Study of Focal and Segmental Glomerulosclerosis according to the Columbia Classification and Its Correlation with the Clinical Outcome"],"prefix":"10.25259","volume":"15","author":[{"given":"Swapna","family":"Nuguri","sequence":"additional","affiliation":[{"name":"Department of Pathology, ESIC Medical College, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Swain","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Apollo Hospitals, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle de","family":"Padua","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Apollo Hospitals, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4760-6259","authenticated-orcid":false,"given":"Swarnalata","family":"Gowrishankar","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Apollo Hospitals, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"issue":"25","key":"ref1","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1056\/NEJMra1106556","article-title":"Focal segmental glomerulosclerosis","volume":"365","author":"V D D'Agati","year":"2011","journal-title":"N Engl J Med"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/sj.ki.5000160","article-title":"Clinical and pathologic characteristics of focal segmental glomerulosclerosis pathologic variants","volume":"69","author":"D B Thomas","year":"2006","journal-title":"Kidney Int"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2021.05.021","article-title":"KDIGO 2021 clinical practice guideline for the management of glomerular diseases","volume":"100","year":"2021","journal-title":"Kidney International"},{"issue":"09","key":"ref4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1159\/000508099","article-title":"Focal segmental glomerulosclerosis: state-of-the-art and clinical perspective","volume":"144","author":"A Shabaka","year":"2020","journal-title":"Nephron"},{"issue":"09","key":"ref5","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41581-021-00427-1","article-title":"Therapeutic trials in adult FSGS: lessons learned and the road forward","volume":"17","author":"A S De Vriese","year":"2021","journal-title":"Nat Rev Nephrol"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/ndt\/gfm523","article-title":"Pathological variants of focal segmental glomerulosclerosis in an adult Dutch population\u2013epidemiology and outcome","volume":"23","author":"J K Deegens","year":"2008","journal-title":"Nephrol Dial Transplant"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1093\/ndt\/gfp328","article-title":"Primary focal segmental glomerulosclerosis in adults: is the Indian cohort different?","volume":"24","author":"R Nada","year":"2009","journal-title":"Nephrol Dial Transplant"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.4103\/1319-2442.100883","article-title":"Histomorphological classification of focal segmental glomerulosclerosis: a critical evaluation of clinical, histologic and morphometric features","volume":"23","author":"P Das","year":"2012","journal-title":"Saudi J Kidney Dis Transpl"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2215\/CJN.06100612","article-title":"Association of histologic variants in FSGS clinical trial with presenting features and outcomes","volume":"8","author":"V D D'Agati","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.5935\/0101-2800.20130019","article-title":"Histologic variants of primary focal segmental glomerulosclerosis: presentation and outcome","volume":"35","author":"L F Arias","year":"2013","journal-title":"J Bras Nefrol"},{"issue":"01","key":"ref11","first-page":"11","article-title":"[Clinicopathologic study of different variants of focal segmental glomerulosclerosis]","volume":"36","author":"S F Shi","year":"2007","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"issue":"04","key":"ref12","first-page":"439","article-title":"[Factors predicting for renal survival in primary focal segmental glomerulosclerosis]","volume":"28","author":"J R Roja","year":"2008","journal-title":"Nefrologia"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1590\/S1676-24442012000300009","article-title":"Study of the morphologic variants of focal segmental glomerulosclerosis: a Brazilian report","volume":"48","author":"L A Testagrossa","year":"2012","journal-title":"J Bras Patol Med Lab"},{"issue":"06","key":"ref14","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/ckj\/sfu100","article-title":"Focal and segmental glomerulosclerosis: clinical and kidney biopsy correlations","volume":"7","author":"S Sethi","year":"2014","journal-title":"Clin Kidney J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2369-15-52","article-title":"Clinical features and outcomes of focal segmental glomerulosclerosis pathologic variants in Korean adult patients","volume":"15","author":"Y E Kwon","year":"2014","journal-title":"BMC Nephrol"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4103\/1319-2442.148772","article-title":"Focal and segmental glomerulosclerosis: does prognosis vary with the variants?","volume":"26","author":"G Swarnalatha","year":"2015","journal-title":"Saudi J Kidney Dis Transpl"},{"issue":"05","key":"ref17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4103\/0971-4065.167283","article-title":"Clinicopathological correlation and treatment response of primary focal segmental glomerulosclerosis in adults and adolescents","volume":"26","author":"J Dhanapriya","year":"2016","journal-title":"Indian J Nephrol"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4103\/ijn.IJN_115_17","article-title":"The spectrum of focal segmental glomerulosclerosis from Eastern India: is it different?","volume":"28","author":"M Trivedi","year":"2018","journal-title":"Indian J Nephrol"},{"issue":"02","key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15171\/npj.2019.24","article-title":"A study on variants of focal segmental glomerulosclerosis and their relationship with various biochemical and demographic parameters in kidney biopsies; a single center study","volume":"8","author":"F Fatehi","year":"2019","journal-title":"J Nephropharmacol"},{"issue":"07","key":"ref20","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/ndt\/gfy374","article-title":"Utility of Columbia classification in focal segmental glomerulosclerosis: renal prognosis and treatment response among the pathological variants","volume":"35","author":"A Tsuchimoto","year":"2020","journal-title":"Nephrol Dial Transplant"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/ckj\/sfx029","article-title":"Collapsing glomerulopathy: a 30-year perspective and single, large center experience","volume":"10","author":"L Nicholas Cossey","year":"2017","journal-title":"Clin Kidney J"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2215\/CJN.15161219","article-title":"APOL1 nephropathy: from genetics to clinical applications","volume":"16","author":"D J Friedman","year":"2021","journal-title":"Clin J Am Soc Nephrol"},{"issue":"08","key":"ref23","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1097\/01.ASN.0000135051.62500.97","article-title":"Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants","volume":"15","author":"M J Chun","year":"2004","journal-title":"J Am Soc Nephrol"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1761930.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T08:21:32Z","timestamp":1703406092000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/a-study-of-focal-and-segmental-glomerulosclerosis-according-to-the-columbia-classification-and-its-correlation-with-the-clinical-outcome\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,24]]},"references-count":23,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,8,2]]},"published-print":{"date-parts":[[2023,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1761930","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"value":"0974-2727","type":"print"},{"value":"0974-7826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,24]]}}}