{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:03:36Z","timestamp":1785251016643,"version":"3.55.0"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"Central Council for Research in Homoeopathy, New Delhi, India"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2003Globally, adenotonsillar hypertrophy (ATH) is one of the most prevalent upper respiratory tract disorders of children, with associated troublesome symptoms such as sleep apnea and cognitive disturbances. In this study, we evaluated the potential role of individualized homeopathic medicines in the management of symptomatic ATH in children.<\/jats:p>\n                  <jats:p>Methods\u2003A multicenter prospective observational study was conducted at five institutes under the Central Council for Research in Homoeopathy, India. Primary and secondary outcomes (symptom score for adenoids, other symptoms of ATH, Mallampati score, tonsillar size, Sleep-Related Breathing Disorder of the Paediatric Sleep Questionnaire [SRBD-PSQ]) were assessed through standardized questionnaires at baseline and at 3, 6, 9 and 12 months. Radiological investigations for assessing the adenoid\/nasopharyngeal (A\/N) ratio were carried out at baseline, 6 and 12 months. All analyses were carried out using an intention-to-treat approach.<\/jats:p>\n                  <jats:p>Results\u2003A total of 340 children were screened and 202 children suffering from ATH were enrolled and followed up monthly for 12 months. Each patient received individualized homeopathic treatment based on the totality of symptoms. Statistically significant reductions in adenoid symptom score, Mallampati score (including tonsillar size), SRBD-PSQ sleep quality assessment and A\/N ratio were found over time up to 12 months (p\u2009&lt;\u20090.001). Homeopathic medicines frequently indicated were Calcarea carbonicum, Phosphorus, Silicea, Sulphur, Calcarea phosphoricum, Pulsatilla, Lycopodium and Tuberculinum. No serious adverse events were recorded during the study period.<\/jats:p>\n                  <jats:p>Conclusion\u2003This study suggests that homeopathic medicines may play a beneficial role in the management of symptomatic ATH in children. Well-designed comparative trials are warranted.<\/jats:p>","DOI":"10.1055\/s-0043-1762591","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T19:12:01Z","timestamp":1680635521000},"page":"032-040","source":"Crossref","is-referenced-by-count":3,"title":["Individualized Homeopathic Medicines in the Management of Symptomatic Adenotonsillar Hypertrophy in Children: A Prospective Observational Study"],"prefix":"10.1055","volume":"113","author":[{"given":"Hima Bindu","family":"Ponnam","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Regional Research Institute for Homoeopathy, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-0037","authenticated-orcid":false,"given":"Roja","family":"Varanasi","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Central Council for Research In Homoeopathy, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratan Chandra","family":"Shil","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Regional Research Institute for Homoeopathy, Agartala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinitha E.","family":"R.","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, National Homoeopathy Research Institute for Mental Health, Kottayam, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meetu","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Dr. D P Rastogi Central Research Institute for Homoeopathy, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Ramteke","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Dr. D P Rastogi Central Research Institute for Homoeopathy, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Karthikeyan","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Homoeopathy Research Institute for Disabilities, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. D.","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Dr. D P Rastogi Central Research Institute for Homoeopathy, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trupti Laxmi","family":"Swain","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Regional Research Institute for Homoeopathy, Agartala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navita","family":"Bagdi","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Central Council for Research In Homoeopathy, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Central Council for Research In Homoeopathy, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K.","family":"Manchanda","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Directorate of AYUSH, NCT Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Oberai","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Central Council for Research In Homoeopathy, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1399-3038.2010.01012.x","article-title":"Non-surgical treatment of adenoidal hypertrophy: the role of treating IgE-mediated inflammation","volume":"21","author":"G Scadding","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"key":"ref2","first-page":"371","article-title":"Ultrastructure of the human palatine tonsil and its functional significance","volume":"56","author":"M 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for practice","volume":"41","author":"J F Gilmartin-Thomas","year":"2018","journal-title":"Aust Prescr"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1055\/s-0040-1708045","article-title":"Recommendations for designing, conducting and reporting observational studies in homeopathy","volume":"109","author":"M Teut","year":"2020","journal-title":"Homeopathy"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4103\/idoj.IDOJ_475_18","article-title":"Clinical trial designs","volume":"10","author":"B Nair","year":"2019","journal-title":"Indian Dermatol Online 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