{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:36:46Z","timestamp":1777397806100,"version":"3.51.4"},"reference-count":41,"publisher":"Mathematical Modelling and Numerical Simulation with Applications","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Genet"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recessive dystrophic epidermolysis bullosa (RDEB) is a severe subtype of epidermolysis bullosa caused by changes in collagen VII with a high risk of early development of cutaneous squamous cell carcinoma (cSCC). This review aimed to discuss the relationship between the recurrent healing process, the appearance of fibrosis, and malignant epithelial transformation in RDEB. We searched PubMed, the Regional Portal of the Virtual Health Library, and Embase for articles on the relationship between blistering, recurrent scarring, and fibrosis in the context of cSCC and RDEB. That alterations of collagen VII result in blister formation, scar deficiency associated with inflammation, and increased expression of transforming growth factor \u03b2. These events promote the differentiation of myofibroblasts and the expression of profibrotic proteins, leading to structural changes and the establishment of a microenvironment favorable to carcinogenesis. Patients with RDEB and areas of recurrent scarring and fibrosis may be more prone to the development of cSCC.<\/jats:p>","DOI":"10.1055\/s-0043-1763257","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T18:55:20Z","timestamp":1677264920000},"page":"097-104","source":"Crossref","is-referenced-by-count":2,"title":["Fibrosis as a Risk Factor for Cutaneous Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa: A Systematic Review"],"prefix":"10.53391","volume":"12","author":[{"given":"Brenda Lam\u00f4nica Rodrigues","family":"de Azevedo","sequence":"additional","affiliation":[{"name":"Federal University of Esp\u00edrito Santo, Health Science Center, Graduate Program in Dental Science, Vit\u00f3ria, ES, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Marim","family":"Roni","sequence":"additional","affiliation":[{"name":"Federal University of Esp\u00edrito Santo, Health Science Center, Morphology Department, Medical School, Vit\u00f3ria, ES, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalie Matuk Fuentes","family":"Torrelio","sequence":"additional","affiliation":[{"name":"Plastic Surgery, Our Lady of Glory Children's Hospital, Debra, Vit\u00f3ria, ES, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6330-996X","authenticated-orcid":false,"given":"Let\u00edcia Nogueira","family":"da Gama-de-Souza","sequence":"additional","affiliation":[{"name":"Federal University of Esp\u00edrito Santo, Health Science Center, Morphology Department, Graduate Program in Dental Science, Vit\u00f3ria, ES, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31409","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/adj.12264","article-title":"Clinical features of gingival lesions in patients with dystrophic 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