{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:53:34Z","timestamp":1740142414821,"version":"3.37.3"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Cerebral changes occur in individuals with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) and seem to predominate in subcortical areas. Little is known about the cognitive decline in the elderly living with HTLV-1.<\/jats:p><jats:p>\n          Objective\u2003To evaluate the cognitive aging of individuals infected with HTLV-1 aged \u2265 50 years.<\/jats:p><jats:p>\n          Methods\u2003This is a cross-sectional study of former blood donors infected with HTLV-1 who have been followed in the cohort of the Interdisciplinary Research Group on HTLV-1 since 1997. The groups of study consisted of 79 HTLV-1 infected individuals aged \u2265 50 years, with 41 of them presenting symptomatic HAM and 38 being asymptomatic carriers, and 59 seronegative individuals (controls) aged \u2265 60 years. All were submitted to the P300 electrophysiological test and neuropsychological tests.<\/jats:p><jats:p>\n          Results\u2003Individuals with HAM presented delayed P300 latency in relation to the other groups, and this latency delay increased progressively with aging. The performance of this group in the neuropsychological tests was also the worst. The HTLV-1- asymptomatic group performance was similar to that of the control group.<\/jats:p><jats:p>\n          Conclusions\u2003Individuals with HAM presented cognitive decline that progressed with aging and, although HTLV-1-asymptomatic carriers appear to present cognitive aging similar to that of healthy elderly people, concern about a subclinical cognitive impairment is warranted in this population.<\/jats:p>","DOI":"10.1055\/s-0043-1763486","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T23:57:07Z","timestamp":1681516627000},"page":"253-262","source":"Crossref","is-referenced-by-count":2,"title":["Elderly people with human T-cell leukemia virus type 1-associated myelopathy present an early impairment in cognitive skills"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7123-8329","authenticated-orcid":false,"given":"Beatriz Rezende Matos de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Infectologia e Medicina Tropical, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3296-4800","authenticated-orcid":false,"given":"Ludimila","family":"Labanca","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Infectologia e Medicina Tropical, Belo Horizonte MG, Brazil."},{"name":"Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de P\u00f3s-Graduac\u00e3o em Ci\u00eancias Fonoaudiol\u00f3gicas, Belo Horizonte MG, Brazil."},{"name":"Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Fonoaudiologia, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-4377","authenticated-orcid":false,"given":"Maria Luiza","family":"Diniz","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Fonoaudiologia, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-0745","authenticated-orcid":false,"given":"Nath\u00e1lia de Castro Botini","family":"Rausse","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Infectologia e Medicina Tropical, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9154-7436","authenticated-orcid":false,"given":"Denise Utsch","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Infectologia e Medicina Tropical, Belo Horizonte MG, Brazil."},{"name":"Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de P\u00f3s-Graduac\u00e3o em Ci\u00eancias Fonoaudiol\u00f3gicas, Belo Horizonte MG, Brazil."},{"name":"Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Otorrinolaringologia, Belo Horizonte MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3389\/fmicb.2012.00388","article-title":"Epidemiological Aspects and World Distribution of HTLV-1 Infection","volume":"3","author":"A Gessain","year":"2012","journal-title":"Front 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